Tom Z. Liang , Qingqing Ding , Lavinia P. Middleton , Yun Wu , Aysegul A. Sahin
{"title":"Characteristics of secretory breast carcinoma with extensive in situ carcinoma components: Clinical and histopathologic analysis","authors":"Tom Z. Liang , Qingqing Ding , Lavinia P. Middleton , Yun Wu , Aysegul A. Sahin","doi":"10.1016/j.hpr.2024.300755","DOIUrl":null,"url":null,"abstract":"<div><p>Secretory breast carcinoma is a rare form of breast cancer characterized by low-grade histology, presence of intracellular eosinophilic secretions, and <em>ETV6</em>-<em>NTRK3</em> fusion. Although several studies have explored the histopathologic features of secretory carcinoma, limited attention has been given to the in situ component. We report 5 cases of secretory breast carcinoma with an extensive intraductal component and describe morphologic and biologic characteristics of the in-situ component of secretory breast carcinoma, along with a detailed review of the literature, and discuss potential diagnostic pitfalls in erroneously identifying the in situ lesion as florid hyperplasia.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"37 ","pages":"Article 300755"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000276/pdfft?md5=93381483903a7dc7a66a41d001bf4529&pid=1-s2.0-S2772736X24000276-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Pathology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772736X24000276","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Secretory breast carcinoma is a rare form of breast cancer characterized by low-grade histology, presence of intracellular eosinophilic secretions, and ETV6-NTRK3 fusion. Although several studies have explored the histopathologic features of secretory carcinoma, limited attention has been given to the in situ component. We report 5 cases of secretory breast carcinoma with an extensive intraductal component and describe morphologic and biologic characteristics of the in-situ component of secretory breast carcinoma, along with a detailed review of the literature, and discuss potential diagnostic pitfalls in erroneously identifying the in situ lesion as florid hyperplasia.
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