Van T.T. Tran , Nhung T. Dao , Thuyen T. Do , Tam T.T. Pham , Duan T. Le , Victor N. Khrustalev , Phuong T.T. Nguyen , Anh T. Le
{"title":"New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies","authors":"Van T.T. Tran , Nhung T. Dao , Thuyen T. Do , Tam T.T. Pham , Duan T. Le , Victor N. Khrustalev , Phuong T.T. Nguyen , Anh T. Le","doi":"10.1016/j.mencom.2024.06.014","DOIUrl":null,"url":null,"abstract":"<div><p>New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both <em>in silico</em> and <em>in vitro</em> studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":"34 4","pages":"Pages 514-517"},"PeriodicalIF":1.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mendeleev Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959943624001913","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.
期刊介绍：
Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications.
Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.
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