{"title":"Drug interactions and pain control","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31200","DOIUrl":null,"url":null,"abstract":"<p>Opioid analgesics such as codeine, hydrocodone, and tramadol undergo metabolism that is mediated by the polymorphic CYP2D6 isoenzyme, and research has shown that a CYP2D6 genotype-guided approach to pain control can optimize effectiveness and/or minimize adverse drug reactions associated with these analgesics in patients with different CYP2D6 genotypes (Smith et al., 2019).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31200","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Opioid analgesics such as codeine, hydrocodone, and tramadol undergo metabolism that is mediated by the polymorphic CYP2D6 isoenzyme, and research has shown that a CYP2D6 genotype-guided approach to pain control can optimize effectiveness and/or minimize adverse drug reactions associated with these analgesics in patients with different CYP2D6 genotypes (Smith et al., 2019).
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