Major depression is not associated with higher myocardial infarction rates: insights from a large database.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-08-13 DOI:10.1080/14796678.2024.2387939

Sarah Meskal, Manrit Gill, Mohammad Reza Movahed, Mehrtash Hashemzadeh, Mehrnoosh Hashemzadeh

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Abstract

Background: Depression has been suggested to increase the risk of cardiovascular disease, but many studies assessed depression after heart disease onset. This study evaluated the association between depression and myocardial infarction (MI) using a large inpatient database.Methods: We analyzed patients from the National Inpatient Sample hospitals from 2005 to 2020, selecting those aged >30 with ICD-9 and ICD-10 codes for segment elevation (ST) elevation myocardial infarction (STEMI), non-ST elevation myocardial elevation (NSTEMI) and major depression.Results: Our data included 4413,113 STEMI patients (224,430 with depression) and 10,421,346 NSTEMI patients (437,058 with depression). No significant association was found between depression and MI. For STEMI, the 2005 odds ratio was 0.12 (95% CI: 0.10-0.15, p < 0.001) and the 2020 odds ratio was 0.71 (95% CI: 0.69-0.73, p < 0.001). Similar patterns were observed for NSTEMI.Conclusion: Depression may not independently be a significant risk factor for MI.

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重度抑郁症与较高的心肌梗死发生率无关：来自大型数据库的启示。

背景：抑郁症被认为会增加罹患心血管疾病的风险，但许多研究都是在心脏病发病后才对抑郁症进行评估。本研究利用大型住院患者数据库评估了抑郁症与心肌梗死（MI）之间的关系：我们分析了 2005 年至 2020 年全国住院病人抽样医院的患者，选择了年龄大于 30 岁、ICD-9 和 ICD-10 编码为节段抬高（ST）心肌梗死（STEMI）、非 ST 段抬高心肌梗死（NSTEMI）和重度抑郁症的患者：我们的数据包括 4413113 名 STEMI 患者（其中 224430 人患有抑郁症）和 10421346 名 NSTEMI 患者（其中 437058 人患有抑郁症）。未发现抑郁症与心肌梗死有明显关联。就 STEMI 而言，2005 年的几率比为 0.12（95% CI：0.10-0.15，p p 结论：抑郁症可能不是导致心肌梗死的一个重要风险因素。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.