Charting the Molecular Terrain of Exercise: The Power of Multi-Omic Mapping.

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2024-08-13 DOI:10.1152/physiol.00024.2024
Daniel H Katz, Malene E Lindholm, Euan A Ashley
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Abstract

Physical activity plays a fundamental role in human health and disease. Exercise has been shown to improve a wide variety of disease states, and the scientific community is committed to understanding the precise molecular mechanisms that underlie the exquisite benefits. This review provides an overview of molecular responses to acute exercise and chronic training, particularly energy mobilization and generation, structural adaptation, inflammation, and immune regulation. Further it offers a detailed discussion on known molecular signals and systemic regulators activated during various forms of exercise and their role in orchestrating health benefits. Critically, the increasing use of multi-omic technologies is explored with an emphasis on how multi-omic and multi-tissue studies contribute to a more profound understanding of exercise biology. These data inform anticipated future advancement in the field and highlight the prospect of integrating exercise with pharmacology for personalized disease prevention and treatment.

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绘制运动分子地形图:多分子图谱的力量
体育锻炼对人类健康和疾病起着至关重要的作用。运动已被证明能改善多种疾病状态,科学界正致力于了解其精妙益处的确切分子机制。本综述概述了急性运动和慢性训练的分子反应,特别是能量动员和生成、结构适应、炎症和免疫调节。此外,它还详细讨论了在各种形式的运动中激活的已知分子信号和系统调节因子,以及它们在协调健康益处方面的作用。重要的是,该书探讨了多基因组技术的日益广泛应用,重点是多基因组和多组织研究如何有助于更深入地了解运动生物学。这些数据为该领域未来的发展提供了预期信息,并强调了将运动与药理学结合起来进行个性化疾病预防和治疗的前景。
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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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