Effects of 6-methoxybenzoxazolinone (6-MBOA) on animals: state of knowledge and open questions

IF 2.1 3区 生物学 Q2 MULTIDISCIPLINARY SCIENCES The Science of Nature Pub Date : 2024-08-14 DOI:10.1007/s00114-024-01930-8
Jia-Yi Shi, Ke-Han Gu, Sheng-Mei Yang, Wan-Hong Wei, Xin Dai
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Abstract

6-methoxybenzoxazolinone (6-MBOA) is a secondary plant metabolite predominantly found in monocotyledonous plants, especially Gramineae. In damaged tissue, 2-β-D-glucopyranosyloxy-4-hydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA-Glc) is hydrolyzed to DIMBOA, which spontaneously decomposes into 6-MBOA. It is commonly detected in plants consumed by voles and livestock and can also be present in cereal-based products. Discovered in 1955, this compound is renowned for its ability to trigger animal reproduction. However, there is a lack of research on its functional and mechanistic properties, leaving much of their potential unexplored. This review aimed to comprehensively summarize the effects of 6-MBOA on animal reproduction and human health, as well as its defensive role against herbivores. Studies have shown that 6-MBOA effectively inhibits the digestion, development, growth, and reproduction of insects. 6-MBOA may act as a partial agonist of melatonin and exert a regulatory role in mammalian reproduction, resulting in either promoting or inhibiting effects. 6-MBOA has been theorized to possess anti-tumor, anti-AIDS, anti-anxiety, and weight-loss effects in humans. However, insufficient attention has been paid to its defense properties against mammalian herbivores, and the mechanisms underlying its effects on mammalian reproduction remain unclear. In addition, research on its impact on human health is still in its preliminary stages. The review emphasizes the need for further systematic and comprehensive research on 6-MBOA to fully understand its diverse functions. Elucidating the effects of 6-MBOA on animal reproduction, adaptation, and human health would advance our understanding of plant–herbivore coevolution and the influence of environmental factors on animal population dynamics. Furthermore, this knowledge could potentially promote its application in human health and animal husbandry.

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6-甲氧基苯并恶唑啉酮(6-MBOA)对动物的影响:知识现状与未决问题。
6-甲氧基苯并恶唑酮(6-MBOA)是一种植物次生代谢物,主要存在于单子叶植物,尤其是禾本科植物中。在受损组织中,2-β-D-吡喃葡萄糖氧基-4-羟基-7-甲氧基-1,4-苯并恶嗪-3-酮(DIMBOA-Glc)会水解为 DIMBOA,DIMBOA 会自发分解为 6-MBOA。田鼠和牲畜食用的植物中通常会检测到这种物质,谷物类产品中也可能含有这种物质。这种化合物于 1955 年被发现,因其能够引发动物繁殖而闻名于世。然而,由于缺乏对其功能和机理特性的研究,其大部分潜力尚未被发掘。本综述旨在全面总结 6-MBOA 对动物繁殖和人类健康的影响,以及它对食草动物的防御作用。研究表明,6-MBOA 能有效抑制昆虫的消化、发育、生长和繁殖。6-MBOA 可作为褪黑激素的部分激动剂,在哺乳动物的繁殖过程中发挥调节作用,从而产生促进或抑制作用。据推测,6-MBOA 对人类具有抗肿瘤、抗艾滋病、抗焦虑和减肥的作用。然而,人们对其抵御哺乳动物食草动物的特性关注不够,对其影响哺乳动物繁殖的机制也尚不清楚。此外,有关其对人类健康影响的研究仍处于初步阶段。综述强调,有必要进一步对 6-MBOA 进行系统、全面的研究,以充分了解其各种功能。阐明 6-MBOA 对动物繁殖、适应和人类健康的影响,将促进我们对植物与食草动物共同进化以及环境因素对动物种群动态影响的理解。此外,这些知识还有可能促进其在人类健康和畜牧业中的应用。
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来源期刊
The Science of Nature
The Science of Nature 综合性期刊-综合性期刊
CiteScore
3.40
自引率
0.00%
发文量
47
审稿时长
4-8 weeks
期刊介绍: The Science of Nature - Naturwissenschaften - is Springer''s flagship multidisciplinary science journal. The journal is dedicated to the fast publication and global dissemination of high-quality research and invites papers, which are of interest to the broader community in the biological sciences. Contributions from the chemical, geological, and physical sciences are welcome if contributing to questions of general biological significance. Particularly welcomed are contributions that bridge between traditionally isolated areas and attempt to increase the conceptual understanding of systems and processes that demand an interdisciplinary approach.
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