Antiphospholipid Syndrome Nephropathy Occurs in Pregnancy: A Case Report

IF 2.5 3区医学 Q3 IMMUNOLOGY American Journal of Reproductive Immunology Pub Date : 2024-08-14 DOI:10.1111/aji.13906

Chao Ji, Yakun Wang, Xiaoxiao Zhai, Guoxin Ji

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Abstract

Objective

This paper presents an analysis of the pregnancy trajectory and therapeutic regimen documentation of a primigravida with APSN. It aims at communicating the therapeutic approach and preventive measures for APSN in pregnancy.

Case Presentation

This paper reports the trajectory and therapeutic regimen documentation of a primigravida with APSN. The APSN was discovered in a primigravida woman aged 26 years at 11 weeks of gestation. The initial therapy regimen consists of daily administration of prednisone 10 mg, hydroxychloroquine 200 mg, dapparin 5000 IU, and aspirin 50 mg. At a gestational age of 20 + 3 weeks, the dosage of dapparin was modified to 5000 IU/other day, along with a significant rise in urinary protein level seen at 30 + 3 weeks of gestational age. The initial dosage of dapanin sodium was renewed. The patient delivered at 38 + 3 weeks of gestation without other complications.

Conclusion

It is imperative to acknowledge that altering the dosage and administration of medication should not be done haphazardly during pregnancy.

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妊娠期发生抗磷脂综合征肾病：病例报告。

目的：本文分析了一名患有 APSN 的初产妇的妊娠轨迹和治疗方案记录。旨在介绍妊娠期 APSN 的治疗方法和预防措施：本文报告了一名患有 APSN 的初产妇的妊娠轨迹和治疗方案记录。一名 26 岁的初产妇在妊娠 11 周时发现了 APSN。最初的治疗方案包括每天服用强的松 10 毫克、羟氯喹 200 毫克、达帕林 5000 IU 和阿司匹林 50 毫克。在胎龄为 20+3 周时，达帕灵的剂量改为 5000 IU/天，同时在胎龄为 30+3 周时发现尿蛋白水平显著上升。达帕宁钠的初始剂量得以延长。患者在妊娠 38+3 周时分娩，未出现其他并发症：我们必须认识到，在怀孕期间不应随意改变药物的剂量和用法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.