Hypothalamus-pituitary-adrenal axis in patients with post-traumatic stress disorders and related to oxidative stress.

IF 1.3 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-08-14 Print Date: 2024-12-17 DOI:10.1515/hmbci-2024-0017

Ali M A Al-Kufaishi, Noor J T Al-Musawi

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Abstract

Objectives: The study involves the effect of hypothalamus-pituitary-adrenal hormones disorders, and related to oxidative stress in individuals with PTSD to those in the healthy group after they experience a specific event that results in a congenital illness or limb loss.

Methods: Obtaining serum samples from males exclusively in cases where psychiatrists have determined that the men have experienced psychological damage brought on by a particular tragedy, and testing the men for hypothalamus-pituitary-adrenal axis and oxidative stress parameters in comparison to healthy participants.

Results: It was observed that there was a notable rise in cortisol levels (5.60 ± 0.93) at 4 pm compared with healthy control (3.43 ± 0.64) resulting from the stimulating effect of the pituitary gland, and this increase has a role in raising levels of oxidative stress in patients total oxidant status (1.08 ± 0.13) compared with control (0.70 ± 0.10). High oxidative stress may lead to increased prolactin levels and decreased testosterone levels.

Conclusions: Transmission of incorrect chemical signals from the central nervous system has a role in causing disturbances in hormonal levels of the hypothalamus and its associated glands, and thus an imbalance in the metabolic rate due to high cortisol. Also, high levels of prolactin hormones play a role in a significant decrease in testosterone levels.

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创伤后应激障碍患者的下丘脑-垂体-肾上腺轴与氧化应激的关系。

研究目的该研究涉及创伤后应激障碍患者与健康组患者在经历导致先天性疾病或肢体缺失的特定事件后，下丘脑-垂体-肾上腺激素紊乱以及氧化应激的相关影响：方法：在精神科医生认定男性经历了特定悲剧带来的心理伤害的情况下，专门采集男性血清样本，并与健康参与者对比，检测男性下丘脑-垂体-肾上腺轴和氧化应激参数：结果发现，与健康对照组（3.43 ± 0.64）相比，下午 4 点时皮质醇水平（5.60 ± 0.93）明显升高，这是由于脑垂体的刺激作用所致；与对照组（0.70 ± 0.10）相比，皮质醇水平（1.08 ± 0.13）的升高有助于提高患者总氧化应激状态的氧化应激水平。高氧化应激可能导致催乳素水平升高和睾酮水平降低：结论：中枢神经系统传递错误的化学信号会导致下丘脑及其相关腺体的激素水平紊乱，从而使皮质醇过高导致新陈代谢率失衡。此外，催乳激素水平过高也会导致睾酮水平显著下降。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.