Oil/water (O/W) nanoemulsions developed from essential oil extracted from wildly growing Calotropis gigantea (Linn.) Aiton F.: synthesis, characterization, stability and evaluation of anti-cancerous, anti-oxidant, anti-inflammatory and anti-diabetic activities.

IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-01 Epub Date: 2024-08-13 DOI:10.1080/09205063.2024.2384801
Arun Dev Sharma, Ravindresh Chhabra, Jyoti Rani, Amrita Chauhan, Inderjeet Kaur, Gaurika Kapoor
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Abstract

Calotropis gigantea essential oil is utilized in outmoded medicine, therapeutics, and the cosmetic industries. However, the extreme volatility, oxidation susceptibility, and instability of this oil restricts its application. Thus, encapsulation is a more effective method of shielding this oil from unfavorable circumstances. The creation of oil/water (O/W) nanoemulsions based on Calotropis gigantea essential oil (CEO), known as CNE (Calotropis gigantea essential oil nanoemulsions), and an assessment of its biological potential were the goals of this work. UV, fluorescence, and FT-IR methods were used for physiological characterization. Biological activities, including anti-inflammatory, anti-diabetic, and anti-cancer effects. Studies on the pharmacokinetics of CNE were conducted. CNEs encapsulation efficiency was found to be 92%. The CNE nanoemulsions had a spherical shape with polydispersity index of 0.531, size of 200 nm, and a zeta potential of -35.9 mV. Even after being stored at various temperatures for 50 days, CNE nanoemulsions remained stable. Numerous tests were used to determine the antioxidant capacity of CNE, and the following IC50 values (µl/mL) were found: iron chelating assay: 18, hydroxyl radical scavenging: 37, and nitric oxide radical scavenging activity: 58. The percentage of HeLa cells that remained viable after being treated with CNE was 41% at a higher dose of 1 µl. CNE inhibited α-amylase in a dose-dependent manner, with 72% inhibition at its higher dose of 250 µL. Research on the kinetics of drugs showed that nanoemulsions showed Higuchi pattern. This research showed potential use of Calotropis gigantea oil-based nanoemulsions in the food, cosmetic, and pharmaceutical industries.

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从野外生长的菖蒲(Calotropis gigantea (Linn.) Aiton F.)中提取的精油开发的油/水(O/W)纳米乳剂:合成、表征、稳定性以及抗癌、抗氧化、抗炎和抗糖尿病活性评估。
石菖蒲精油可用于过时的医药、治疗和化妆品行业。然而,这种精油的极度挥发性、易氧化性和不稳定性限制了它的应用。因此,封装是保护这种精油免受不利环境影响的更有效方法。本研究的目标是创建基于千层塔精油(CEO)的油/水(O/W)纳米乳液,即千层塔精油纳米乳液(CNE),并对其生物潜力进行评估。研究人员采用紫外线、荧光和傅立叶变换红外方法对其进行了生理表征。生物活性,包括抗炎、抗糖尿病和抗癌作用。对 CNE 的药代动力学进行了研究。发现 CNE 的封装效率为 92%。CNE 纳米乳液呈球形,多分散指数为 0.531,大小为 200 nm,Zeta 电位为 -35.9 mV。即使在不同温度下储存 50 天,CNE 纳米乳液仍然保持稳定。为确定 CNE 的抗氧化能力,我们进行了多项测试,结果发现其 IC50 值(微升/毫升)如下:铁螯合实验:18;清除羟自由基:37;清除一氧化氮自由基:37:用 1 µl 的较高剂量 CNE 处理 HeLa 细胞后,其存活率为 41%。氯化萘以剂量依赖的方式抑制α-淀粉酶,在 250 微升的较高剂量下,抑制率为 72%。对药物动力学的研究表明,纳米乳剂呈现出樋口模式。这项研究表明,以石菖蒲油为基础的纳米乳液在食品、化妆品和制药行业具有潜在用途。
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来源期刊
Journal of Biomaterials Science, Polymer Edition
Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学:生物材料
CiteScore
7.10
自引率
5.60%
发文量
117
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.
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