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Design and characterization of nasal release system using ritonavir-imprinted pHEMA nanoparticles.
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-03 DOI: 10.1080/09205063.2025.2486857
Cansun Arıkan, Merve Çalışır, Muhammed Erkek, Adil Denizli, Nilay Bereli

The exceptional ability of molecularly imprinted polymers (MIPs) to recognize specific molecular structures has recently facilitated their use in biomedical applications, including drug release. Controlled nasal drug release techniques effectively target specific tissues with optimal doses, timing, and location for therapeutic effects. This approach is advantageous due to the slightly acidic pH and low enzymatic activity in this region. MIPs are employed in these areas to enhance specificity and efficacy in drug release systems. This study aims to design an effective controlled nasal drug release system by imprinting the antiretroviral drug Ritonavir (RTV) onto pHEMA-based molecularly imprinted nanoparticles. Attenuated total reflection Fourier-transform infrared spectroscopy (FTIR-ATR), zeta-size analysis, and scanning electron microscopy (SEM) were used to characterize the nanoparticles, verifying their spherical shape, content and consistent size distribution. Zeta-size analysis revealed that RTV-imprinted p(HEMA-MATrp) nanoparticles had an average size of 88.46 nm with a polydispersity index of 0.279. The MIP nanoparticles possessed a specific surface area of 628.34 m2/g. In vitro release studies showed controlled release behavior of RTV-loaded nanoparticles, fitting the Korsmeyer-Peppas model. At 2.0 mg/mL, 71% cumulative release was observed after 10 h. The cumulative release of the was lowest at pH 4.0 (26%) and highest at pH 7.4 (32%) for 1.0 mg/mL loaded p(HEMA-MATrp) nanoparticles. MTT cytotoxicity tests on L929 cells indicated reduced cytotoxicity and good biocompatibility. These results suggest RTV-imprinted p(HEMA-MATrp) nanoparticles as an effective drug release system for antiretroviral therapies.

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引用次数: 0
A comprehensive review on using injectable chitosan microgels for osteochondral tissue repair. 关于使用可注射壳聚糖微凝胶修复骨软骨组织的全面综述。
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-10-26 DOI: 10.1080/09205063.2024.2419715
Sarah Salehi

Restoring cartilage to healthy state is challenging due to low cell density and hence low regenerative capacity. The current platforms are not compatible with clinical translation and require dedicated handling of trained personnel. However, by engineering and implanting cell microaggregates in higher concentrations, efficient formation of new cartilage can be achieved, even in the absence of exogenous growth factors. Therefore, one-step surgeries are preferable for novel treatments and we need cell laden microgels allowing the formation of microaggregaets in vivo. Injectability is a key parameter for in situ forming the shape and minimally invasive clinical applications. Hydrogels as bioinks can restore damaged tissues to their primary shape. Chitosan is a polysaccharide derived from chitin with abundant usage in tissue engineering. This review highlights the use of chitosan as an injectable hydrogel for osteochondral defects. Several studies focused on encapsulating mesenchymal stem cells within chitosan hydrogels have been categorized and incorporating microfluidic devices has been identified in the forefront to form microgels. Additionally, the printability is another convenience of chitosan for using in 3D printing for cartilage tissue engineering which is described in this review.

由于细胞密度低,因此再生能力也低,将软骨恢复到健康状态具有挑战性。目前的平台与临床转化不兼容,需要训练有素的人员专门处理。然而,通过设计和植入高浓度的细胞微聚集体,即使在没有外源性生长因子的情况下,也能有效地形成新软骨。因此,对于新疗法来说,一步到位的手术是更可取的,我们需要能在体内形成微聚集体的含细胞微凝胶。可注射性是原位成形和微创临床应用的关键参数。水凝胶作为生物墨水,可使受损组织恢复原形。壳聚糖是一种从甲壳素中提取的多糖,在组织工程中应用广泛。本综述重点介绍壳聚糖作为可注射水凝胶在骨软骨缺损中的应用。几项研究的重点是将间充质干细胞封装在壳聚糖水凝胶中,并将微流体设备纳入形成微凝胶的最前沿。此外,可打印性也是壳聚糖用于软骨组织工程三维打印的另一个便利之处,本综述将对此进行介绍。
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引用次数: 0
A systematic review on hyaluronic acid coated nanoparticles: recent strategy in breast cancer management. 透明质酸涂层纳米粒子系统综述:乳腺癌治疗的最新策略
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-10-21 DOI: 10.1080/09205063.2024.2416293
Seema S Rathore, J Josephine Leno Jenita, Manjula Dotherabandi

Hyaluronic acid, a non-sulphated glycosaminoglycan has attracted its usage in the management of breast cancer. Drug-loaded nanoparticles with hyaluronic acid surface modifications show potential as a promising method for targeting and delivering drugs to the tumor site. The aim of this study was to conduct a systematic review of articles and assess the impact of hyaluronic acid coated nanoparticles on breast cancer. The various database were used for this comprehensive review. The inclusion and exclusion criteria were selected according to the PRISMA guidelines. Studies associated with characterization, in vitro, and in vivo studies were collected and subjected for further analysis. According to the inclusion criteria, 41 literature were selected for analysis. From all the studies, it was observed that the nanoparticles coated with hyaluronic acid produced better particle size, shape, zeta potential, increased in vitro cytotoxicity, cellular uptake, cell apoptosis, and anti-tumor effect in vivo. Research has shown that hyaluronic acid exhibits a higher affinity for CD44 receptors, resulting in enhanced targeted nanoparticle activity on cancer cells while sparing normal cells.

透明质酸是一种非硫酸化的糖胺聚糖,已被广泛用于乳腺癌的治疗。经过透明质酸表面修饰的载药纳米颗粒显示出作为靶向药物输送到肿瘤部位的一种有潜力的方法。本研究旨在对相关文章进行系统综述,评估透明质酸涂层纳米粒子对乳腺癌的影响。本综述使用了各种数据库。纳入和排除标准根据 PRISMA 指南进行选择。收集并进一步分析了与表征、体外和体内研究相关的研究。根据纳入标准,共选择了 41 篇文献进行分析。从所有研究中观察到,涂有透明质酸的纳米颗粒具有更好的粒度、形状、ZETA电位,体外细胞毒性、细胞摄取、细胞凋亡和体内抗肿瘤效果都有所提高。研究表明,透明质酸对 CD44 受体具有更高的亲和力,从而增强了纳米粒子对癌细胞的靶向活性,同时保护了正常细胞。
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引用次数: 0
Lecithin-based mixed polymeric micelles for activity improvement of curcumin against Staphylococcus aureus. 基于卵磷脂的混合聚合物胶束用于提高姜黄素对金黄色葡萄球菌的活性。
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-10-26 DOI: 10.1080/09205063.2024.2421089
Yunjing Jia, Yuli Li, Mingzhu Wang, Fuyou Wang, Qingmin Liu, Zhimei Song

Considering cellular uptake promotion of lecithin and high expression of phospholipase in S. aureus, we designed curcumin (Cur)-loaded soy lecithin-based mPEG-PVL copolymer micelles (MPPC). The effect of soy lecithin on the anti-S. aureus activity of the formulation was studied with cur-loaded mPEG-PVL micelles (MPC without soy lecithin) as control. It was found that MPPC enhanced the water-solubility of Cur, and showed slow and sustained release behavior of Cur. Although MPPC had the same anti-S. aureus activity as Cur, its activity was significantly higher than MPC due to the cellular uptake promotion of soybean lecithin. It was noted that MPPC had good inhibition or destruction effect on biofilm, significant cell membrane damage, strong inhibition effect on protease or lipase production, and obvious induction effect on ROS expression when compared with Cur and MPC. So, the introduction of soy lecithin could improve the antibacterial activity of Cur. The lecithin-based micelles would offer potential to deliver antibacterial drugs for improved therapeutic action.

考虑到卵磷脂对细胞吸收的促进作用以及金黄色葡萄球菌磷脂酶的高表达,我们设计了姜黄素(Cur)负载大豆卵磷脂的 mPEG-PVL 共聚物胶束(MPPC)。以姜黄素负载的 mPEG-PVL 胶束(不含大豆卵磷脂的 MPC)为对照,研究了大豆卵磷脂对制剂抗金黄色葡萄球菌活性的影响。结果发现,MPPC 提高了 Cur 的水溶性,并显示出 Cur 的缓释和持续释放行为。虽然 MPPC 与 Cur 具有相同的抗金黄色葡萄球菌活性,但由于大豆卵磷脂促进了细胞吸收,其活性明显高于 MPC。研究指出,与 Cur 和 MPC 相比,MPPC 对生物膜有良好的抑制或破坏作用,对细胞膜有明显的破坏作用,对蛋白酶或脂肪酶的产生有较强的抑制作用,对 ROS 的表达有明显的诱导作用。因此,引入大豆卵磷脂可以提高 Cur 的抗菌活性。以卵磷脂为基础的胶束有可能输送抗菌药物,提高治疗效果。
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引用次数: 0
Mechanical properties and biocompatibility characterization of 3D printed collagen type II/silk fibroin/hyaluronic acid scaffold. 三维打印 II 型胶原蛋白/丝纤维素/透明质酸支架的力学性能和生物相容性表征。
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-10-10 DOI: 10.1080/09205063.2024.2411797
Lilan Gao, Yali Li, Gang Liu, Xianglong Lin, Yansong Tan, Jie Liu, Ruixin Li, Chunqiu Zhang

Damage to articular cartilage is irreversible and its ability to heal is minimal. The development of articular cartilage in tissue engineering requires suitable biomaterials as scaffolds that provide a 3D natural microenvironment for the development and growth of articular cartilage. This study aims to investigate the applicability of a 3D printed CSH (collagen type II/silk fibroin/hyaluronic acid) scaffold for constructing cartilage tissue engineering. The results showed that the composite scaffold had a three-dimensional porous network structure with uniform pore sizes and good connectivity. The hydrophilicity of the composite scaffold was 1071.7 ± 131.6%, the porosity was 85.12 ± 1.6%, and the compressive elastic modulus was 36.54 ± 2.28 kPa. The creep and stress relaxation constitutive models were also established, which could well describe the visco-elastic mechanical behavior of the scaffold. The biocompatibility experiments showed that the CSH scaffold was very suitable for the adhesion and proliferation of chondrocytes. Under dynamic compressive loading conditions, it was able to promote cell adhesion and proliferation on the scaffold surface. The 3D printed CSH scaffold is expected to be ideal for promoting articular cartilage regeneration.

关节软骨的损伤是不可逆的,其愈合能力也微乎其微。组织工程中的关节软骨发育需要合适的生物材料作为支架,为关节软骨的发育和生长提供三维自然微环境。本研究旨在探讨三维打印 CSH(II 型胶原蛋白/丝状纤维素/透明质酸)支架在构建软骨组织工程中的适用性。结果表明,该复合支架具有三维多孔网络结构,孔隙大小均匀,连通性良好。复合支架的亲水性为 1071.7 ± 131.6%,孔隙率为 85.12 ± 1.6%,压缩弹性模量为 36.54 ± 2.28 kPa。同时还建立了蠕变和应力松弛组成模型,很好地描述了支架的粘弹性力学行为。生物相容性实验表明,CSH 支架非常适合软骨细胞的粘附和增殖。在动态压缩加载条件下,它能促进细胞在支架表面的粘附和增殖。三维打印 CSH 支架有望成为促进关节软骨再生的理想材料。
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引用次数: 0
ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway. ROS响应性纳米细胞包裹的仙鹤草醇通过调节NF-κB信号通路,改善压力过载诱导的心肌肥大。
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-10-14 DOI: 10.1080/09205063.2024.2411095
Shanjiang Chen, Jianjian Yang, Fuli Liu

Celastrol (CEL) belongs to the group of non-steroidal immunosuppressants with the potential to improve cardiac hypertrophy (CH). However, the poor biocompatibility and low bioavailability of CEL limit its in vivo application. This study was aimed to develop a targeted drug delivery system that can efficiently and safely deliver CEL to target tissues, providing a research basis for the application of CEL in CH therapy. A novel ROS-sensitive drug-loaded nanomicelle, dodecanoic acid (DA)-phenylboronic acid pinacol ester-dextran polymer encapsulating CEL (DBD@CEL), was synthesized using chemical synthesis. Then, the morphology, particle size, drug-loaded content, and ROS-responsive release behavior of DBD@CEL were studied. Pharmacokinetics and biocompatibility were evaluated using healthy mice. Finally, the ability and mechanism of DBD@CEL in improving CH in vivo were investigated using a mouse CH model. DBD@CEL was successfully prepared with a drug loading of 18.9%. It exhibited excellent stability with an average particle size of 110.0 ± 1.7 nm. Within 48 h, DBD@CEL released only 19.4% in the absence of H2O2, while in the presence of 1 mM H2O2, the release rate increased to 71.5%. Biocompatibility studies indicated that DBD@CEL did not cause blood cell hemolysis, had no impact on normal organs, and did not result in abnormal blood biochemical indicators, demonstrating excellent biocompatibility. In vivo studies revealed that DBD@CEL regulated the activation of NF-κB signaling, inhibits pyroptosis and oxidative stress, and thereby ameliorates CH. The ROS-responsive DBD@CEL nanodrug delivery system enhances the therapeutic activity of CEL for CH, providing a promising drug delivery system for the clinical treatment of CH.

塞拉斯托(CEL)属于非甾体类免疫抑制剂,具有改善心脏肥大(CH)的潜力。然而,CEL 的生物相容性差、生物利用度低,限制了其在体内的应用。本研究旨在开发一种靶向给药系统,该系统能高效、安全地将CEL输送到靶组织,为CEL在CH治疗中的应用提供研究基础。本研究采用化学合成法合成了一种新型的ROS敏感药物载药纳米胶束--十二烷酸(DA)-苯硼酸频哪醇酯-葡聚糖聚合物包裹CEL(DBD@CEL)。然后,研究了 DBD@CEL 的形态、粒度、载药量和 ROS 响应释放行为。利用健康小鼠评估了药代动力学和生物相容性。最后,利用小鼠CH模型研究了DBD@CEL改善体内CH的能力和机制。DBD@CEL 制备成功,载药量为 18.9%。它具有极佳的稳定性,平均粒径为 110.0 ± 1.7 nm。在没有 H2O2 的情况下,DBD@CEL 在 48 小时内的释放率仅为 19.4%,而在有 1 mM H2O2 的情况下,释放率则增加到 71.5%。生物相容性研究表明,DBD@CEL 不会引起血细胞溶血,对正常器官没有影响,也不会导致血液生化指标异常,表现出良好的生物相容性。体内研究表明,DBD@CEL 可调节 NF-κB 信号的活化,抑制热蛋白沉积和氧化应激,从而改善 CH。ROS响应的DBD@CEL纳米给药系统增强了CEL对CH的治疗活性,为临床治疗CH提供了一种前景广阔的给药系统。
{"title":"ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway.","authors":"Shanjiang Chen, Jianjian Yang, Fuli Liu","doi":"10.1080/09205063.2024.2411095","DOIUrl":"10.1080/09205063.2024.2411095","url":null,"abstract":"<p><p>Celastrol (CEL) belongs to the group of non-steroidal immunosuppressants with the potential to improve cardiac hypertrophy (CH). However, the poor biocompatibility and low bioavailability of CEL limit its <i>in vivo</i> application. This study was aimed to develop a targeted drug delivery system that can efficiently and safely deliver CEL to target tissues, providing a research basis for the application of CEL in CH therapy. A novel ROS-sensitive drug-loaded nanomicelle, dodecanoic acid (DA)-phenylboronic acid pinacol ester-dextran polymer encapsulating CEL (DBD@CEL), was synthesized using chemical synthesis. Then, the morphology, particle size, drug-loaded content, and ROS-responsive release behavior of DBD@CEL were studied. Pharmacokinetics and biocompatibility were evaluated using healthy mice. Finally, the ability and mechanism of DBD@CEL in improving CH <i>in vivo</i> were investigated using a mouse CH model. DBD@CEL was successfully prepared with a drug loading of 18.9%. It exhibited excellent stability with an average particle size of 110.0 ± 1.7 nm. Within 48 h, DBD@CEL released only 19.4% in the absence of H<sub>2</sub>O<sub>2</sub>, while in the presence of 1 mM H<sub>2</sub>O<sub>2</sub>, the release rate increased to 71.5%. Biocompatibility studies indicated that DBD@CEL did not cause blood cell hemolysis, had no impact on normal organs, and did not result in abnormal blood biochemical indicators, demonstrating excellent biocompatibility. <i>In vivo</i> studies revealed that DBD@CEL regulated the activation of NF-κB signaling, inhibits pyroptosis and oxidative stress, and thereby ameliorates CH. The ROS-responsive DBD@CEL nanodrug delivery system enhances the therapeutic activity of CEL for CH, providing a promising drug delivery system for the clinical treatment of CH.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"545-563"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and improvements in multi-layer mucosa-adhesive films for oral diseases treatment and prognosis. 用于口腔疾病治疗和预后的多层粘膜粘合薄膜的挑战与改进。
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI: 10.1080/09205063.2024.2422213
Ruohan Zhai, Yaxian Liang, Ruijianghan Shi, Huixu Xie

Due to the complexity of oral physiology and pathology, the treatment of oral diseases faces multiple and complex clinical requirements. Mucosa-adhesive films (MAFs) with a single layer have demonstrated considerable potential in delivering therapeutic bioactive ingredients directly to the site of oral diseases. However, their functions are often hindered by certain factors such as limited loading capacity, poor site specificity, and sensitivity to mechanical stimuli. To overcome these limitations, the development of multi-layer MAFs has become a focal point for recent research. This involves the improvement of construction methods for multi-layer MAFs to minimize potential health risks from residual solvents, and conducting comprehensive in vivo studies to evaluate their safety and therapeutic efficacy more accurately, thus paving the way for their commercialization. Additionally, the exploration of multi-layer MAFs as personalized drug delivery systems could further broaden their application prospect. Precisely, multi-layer MAFs compensate for the shortcomings of current therapeutic strategies for oral diseases to a great extent, indicating a promising future in the market.

由于口腔生理和病理的复杂性,口腔疾病的治疗面临着多种复杂的临床要求。单层粘膜黏附膜(MAFs)在将治疗生物活性成分直接输送到口腔疾病部位方面具有相当大的潜力。然而,它们的功能往往受到某些因素的阻碍,例如有限的负载能力、较差的部位特异性以及对机械刺激的敏感性。为了克服这些局限性,开发多层 MAF 已成为近期研究的重点。这包括改进多层 MAF 的构造方法,最大限度地减少残留溶剂对健康的潜在危害,以及开展全面的体内研究,更准确地评估其安全性和疗效,从而为其商业化铺平道路。此外,将多层 MAFs 作为个性化给药系统的探索也将进一步拓宽其应用前景。确切地说,多层 MAF 在很大程度上弥补了目前口腔疾病治疗策略的不足,市场前景广阔。
{"title":"Challenges and improvements in multi-layer mucosa-adhesive films for oral diseases treatment and prognosis.","authors":"Ruohan Zhai, Yaxian Liang, Ruijianghan Shi, Huixu Xie","doi":"10.1080/09205063.2024.2422213","DOIUrl":"10.1080/09205063.2024.2422213","url":null,"abstract":"<p><p>Due to the complexity of oral physiology and pathology, the treatment of oral diseases faces multiple and complex clinical requirements. Mucosa-adhesive films (MAFs) with a single layer have demonstrated considerable potential in delivering therapeutic bioactive ingredients directly to the site of oral diseases. However, their functions are often hindered by certain factors such as limited loading capacity, poor site specificity, and sensitivity to mechanical stimuli. To overcome these limitations, the development of multi-layer MAFs has become a focal point for recent research. This involves the improvement of construction methods for multi-layer MAFs to minimize potential health risks from residual solvents, and conducting comprehensive <i>in vivo</i> studies to evaluate their safety and therapeutic efficacy more accurately, thus paving the way for their commercialization. Additionally, the exploration of multi-layer MAFs as personalized drug delivery systems could further broaden their application prospect. Precisely, multi-layer MAFs compensate for the shortcomings of current therapeutic strategies for oral diseases to a great extent, indicating a promising future in the market.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"663-687"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing.
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-01 DOI: 10.1080/09205063.2025.2486859
Danna V Hernandez-Urquizo, Jesús A Claudio Rizo, Denis A Cabrera-Munguía, Martín Caldera-Villalobos, Maria I León-Campos, Francisco J Enríquez-Medrano, Luis Ernesto Elizalde-Herrera

The current challenge in developing wound healing dressings lies in achieving antibacterial effects while avoiding cytotoxicity to cells that are crucial for the healing process. Addressing this challenge, Zeolitic Imidazolate Framework-67 (ZIF-67), a cobalt-containing metal-organic framework (MOF), has emerged as a promising additive due to cobalt's broad-spectrum antimicrobial effects. This study developed semi-interpenetrating polymer network (semi-IPN) hydrogels by incorporating 1-3 wt.% ZIF-67 into collagen-guar gum matrices, resulting in biocomposites with tunable structural and functional properties. These biocomposites exhibit a fibrillar-granular morphology, uniform cobalt ion distribution on a semi-crystalline surface, and strong antibacterial activity against Escherichia coli (E. coli). At 3 wt.%, ZIF-67 accelerates gelation, strengthens crosslinking interactions, and enhances the storage modulus, thermal stability, and hydrolytic resistance of the hydrogels. Furthermore, biocomposites with 1 wt.% ZIF-67 also function as in-situ curcumin delivery systems, offering controlled release under physiological conditions and significant biodegradation in the presence of collagenase. In vitro tests demonstrate that the chemical composition of these hydrogels, regardless of ZIF-67 content, effectively supports monocyte and fibroblast metabolic activity, promotes cell proliferation, and increases interleukin-10 (IL-10) secretion by human monocytes. Additionally, the absence of hemolytic effects in human blood further underscores the safety and suitability of these hydrogel biocomposites for advanced wound treatment applications.

{"title":"Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing.","authors":"Danna V Hernandez-Urquizo, Jesús A Claudio Rizo, Denis A Cabrera-Munguía, Martín Caldera-Villalobos, Maria I León-Campos, Francisco J Enríquez-Medrano, Luis Ernesto Elizalde-Herrera","doi":"10.1080/09205063.2025.2486859","DOIUrl":"https://doi.org/10.1080/09205063.2025.2486859","url":null,"abstract":"<p><p>The current challenge in developing wound healing dressings lies in achieving antibacterial effects while avoiding cytotoxicity to cells that are crucial for the healing process. Addressing this challenge, Zeolitic Imidazolate Framework-67 (ZIF-67), a cobalt-containing metal-organic framework (MOF), has emerged as a promising additive due to cobalt's broad-spectrum antimicrobial effects. This study developed semi-interpenetrating polymer network (semi-IPN) hydrogels by incorporating 1-3 wt.% ZIF-67 into collagen-guar gum matrices, resulting in biocomposites with tunable structural and functional properties. These biocomposites exhibit a fibrillar-granular morphology, uniform cobalt ion distribution on a semi-crystalline surface, and strong antibacterial activity against <i>Escherichia coli (E. coli)</i>. At 3 wt.%, ZIF-67 accelerates gelation, strengthens crosslinking interactions, and enhances the storage modulus, thermal stability, and hydrolytic resistance of the hydrogels. Furthermore, biocomposites with 1 wt.% ZIF-67 also function as <i>in-situ</i> curcumin delivery systems, offering controlled release under physiological conditions and significant biodegradation in the presence of collagenase. <i>In vitro</i> tests demonstrate that the chemical composition of these hydrogels, regardless of ZIF-67 content, effectively supports monocyte and fibroblast metabolic activity, promotes cell proliferation, and increases interleukin-10 (IL-10) secretion by human monocytes. Additionally, the absence of hemolytic effects in human blood further underscores the safety and suitability of these hydrogel biocomposites for advanced wound treatment applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amphoteric ionic hydrogels containing graphene oxide and bioactive glass loaded with BMP-2 significantly promoted the proliferation and osteogenic differentiation of BMSCs.
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-03-26 DOI: 10.1080/09205063.2025.2480881
Yaru Zhu, Ruiming Yan, Tao Wang, Qidong Wang

The treatment of bone nonunion is a tricky challenge, and the development of bone tissue engineering has provided a direction for the treatment of bone nonunion, making the search for suitable tissue-engineered scaffolds particularly important. Three hydrogel scaffolds were constructed, their physical properties and osteogenesis-promoting properties were compared, and the characteristics of the three scaffolds were studied in vivo and in vitro. Z-CS/BG/GO group scaffolds have more uniform pore size and porosity than other groups, with better inter-pore connectivity. The scaffolds were favorable for BMP-2 loading and possessed good mechanical properties while enabling smoother drug release, thus achieving good promotion of proliferation and bone differentiation of BMSCs. So, Z-CS/BG/GO scaffolds are good materials to promote the differentiation of BMSCs and bone formation.

{"title":"Amphoteric ionic hydrogels containing graphene oxide and bioactive glass loaded with BMP-2 significantly promoted the proliferation and osteogenic differentiation of BMSCs.","authors":"Yaru Zhu, Ruiming Yan, Tao Wang, Qidong Wang","doi":"10.1080/09205063.2025.2480881","DOIUrl":"https://doi.org/10.1080/09205063.2025.2480881","url":null,"abstract":"<p><p>The treatment of bone nonunion is a tricky challenge, and the development of bone tissue engineering has provided a direction for the treatment of bone nonunion, making the search for suitable tissue-engineered scaffolds particularly important. Three hydrogel scaffolds were constructed, their physical properties and osteogenesis-promoting properties were compared, and the characteristics of the three scaffolds were studied <i>in vivo</i> and <i>in vitro</i>. Z-CS/BG/GO group scaffolds have more uniform pore size and porosity than other groups, with better inter-pore connectivity. The scaffolds were favorable for BMP-2 loading and possessed good mechanical properties while enabling smoother drug release, thus achieving good promotion of proliferation and bone differentiation of BMSCs. So, Z-CS/BG/GO scaffolds are good materials to promote the differentiation of BMSCs and bone formation.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing.
IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2025-03-13 DOI: 10.1080/09205063.2025.2476288
Fateme Sanati, Mansoureh Ashghali Farahani, Mohammad Reza Rostami-Darounkola, Fatemeh Shokrolahi, Mohsen Naseri

Nowadays, extensive research has been conducted on electrospun nanofibers for wound dressing applications. Considering the growing concern over bacterial resistance to common antibiotics, investigating the potential of natural essential oils with antibacterial properties could prove to be beneficial in addressing this issue. In response to the challenges posed by impaired wound healing, we have designed a novel electrospun polyvinyl alcohol/chitosan nanofiber embedded with myrtle essential oil and gum Arabic dispersion (PVA/CS/MT-GA). The morphology and molecular structure of the prepared nanofibers were evaluated by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) analysis. The synthesized PVA/CS/MT-GA composite demonstrated a remarkable swelling capacity of 744% and exhibited acceptable mechanical strength. Additionally, the water vapor transmission rate (WVTR) of these nanofibers was obtained as 2497 g.m-2.day-1, which falls within the ideal range for wound dressings. The antimicrobial test results revealed that PVA/CS/MT-GA nanofibers exhibited notable antibacterial properties when tested against Escherichia coli and Staphylococcus aureus. The release profile of MT from MT-containing nanofibers exhibited a burst release mechanism in PVA/CS/MT-GA nanofibers, which can be beneficial in applications that require an immediate therapeutic effect. Furthermore, nanofibers as wound dressings in the full-thickness wound model of Wistar rats demonstrated a remarkable capacity to care for damaged tissue and promote faster healing times. Collectively, the results obtained in this study suggest that the developed nanofiber holds great promise as a potential candidate for wound dressing applications.

如今,人们对用于伤口敷料的电纺纳米纤维进行了广泛的研究。考虑到细菌对普通抗生素的耐药性问题日益受到关注,研究具有抗菌特性的天然精油的潜力将有助于解决这一问题。为了应对伤口愈合受损带来的挑战,我们设计了一种新型电纺聚乙烯醇/壳聚糖纳米纤维,其中嵌入了桃金娘精油和阿拉伯树胶分散体(PVA/CS/MT-GA)。通过扫描电子显微镜(SEM)和傅立叶变换红外(FTIR)分析评估了所制备纳米纤维的形态和分子结构。合成的 PVA/CS/MT-GA 复合材料具有 744% 的显著溶胀能力和可接受的机械强度。此外,这些纳米纤维的水蒸气透过率(WVTR)为 2497 g.m-2.day-1,属于伤口敷料的理想范围。抗菌测试结果表明,PVA/CS/MT-GA 纳米纤维对大肠杆菌和金黄色葡萄球菌具有显著的抗菌性能。含有 MT 的纳米纤维中 MT 的释放曲线表明,PVA/CS/MT-GA 纳米纤维中的 MT 具有猝灭释放机制,这有利于需要立即产生治疗效果的应用。此外,在 Wistar 大鼠的全厚伤口模型中,纳米纤维作为伤口敷料显示出显著的护理受损组织的能力,并能促进伤口的快速愈合。总之,本研究获得的结果表明,所开发的纳米纤维有望成为伤口敷料的潜在候选材料。
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引用次数: 0
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