Vagus nerve stimulation (VNS) preventing postoperative cognitive dysfunction (POCD): two potential mechanisms in cognitive function.

IF 3.5 2区 生物学 Q3 CELL BIOLOGY Molecular and Cellular Biochemistry Pub Date : 2025-03-01 Epub Date: 2024-08-13 DOI:10.1007/s11010-024-05091-0
Zi-Feng Xie, Sheng-Yu Wang, Yuan Gao, Yi-Dan Zhang, Ya-Nan Han, Jin Huang, Mei-Na Gao, Chun-Guang Wang
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Abstract

Postoperative cognitive dysfunction (POCD) impacts a significant number of patients annually, frequently impairing their cognitive abilities and resulting in unfavorable clinical outcomes. Aimed at addressing cognitive impairment, vagus nerve stimulation (VNS) is a therapeutic approach, which was used in many mental disordered diseases, through the modulation of vagus nerve activity. In POCD model, the enhancement of cognition function provided by VNS was shown, demonstrating VNS effect on cognition in POCD. In the present study, we primarily concentrates on elucidating the role of the VNS improving the cognitive function in POCD, via two potential mechanisms: the inflammatory microenvironment and epigenetics. This study provided a theoretical support for the feasibility that VNS can be a potential method to enhance cognition function in POCD.

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迷走神经刺激(VNS)预防术后认知功能障碍(POCD):认知功能的两种潜在机制。
术后认知功能障碍(POCD)每年影响大量患者,经常损害他们的认知能力,导致不利的临床结果。迷走神经刺激(VNS)是一种旨在解决认知障碍的治疗方法,它通过调节迷走神经的活动,被用于许多精神障碍疾病的治疗。在 POCD 模型中,迷走神经刺激可增强认知功能,这表明迷走神经刺激对 POCD 的认知功能有影响。在本研究中,我们主要通过炎症微环境和表观遗传学这两种潜在机制来阐明 VNS 在 POCD 中改善认知功能的作用。这项研究为 VNS 成为增强 POCD 认知功能的一种潜在方法的可行性提供了理论支持。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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