Intracellular infection of Cutibacterium acnes in macrophages of extensive peri-implantitis lesions: A clinical case series.

Jin-Young Park, Dawool Han, Yuan Park, Eunae Sandra Cho, Jong In Yook, Jung-Seok Lee
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Abstract

Cutibacterium acnes is a facultative anaerobic, gram-positive rod, and a commensal bacterium of the body surface including oral cavity. A causal relationship between C. acnes and chronic granulomatous diseases, such as sarcoidosis and orthopedic implant-associated infections, has been previously reported. Typically, C. acnes has been observed inside macrophages, allowing evasion of host immunity, and triggering a persistent inflammatory response. However, such findings have not been reported in peri-implantitis lesions. In this case series, we collected inflamed tissues from extensive peri-implantitis lesions of eight patients. Out of the eight samples, seven tested positive for the 16 s rRNA gene of C. acnes by polymerase chain reaction, and six were positive by immunohistochemistry. Immunohistochemical staining revealed the presence of C. acnes in the cytoplasm of macrophages, suggesting a role in lesion formation. This finding may enhance our understanding of the pathophysiology of persistent peri-implantitis lesions and provide implications for future therapy.

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广泛种植体周围炎病变巨噬细胞中的痤疮杆菌胞内感染:临床病例系列。
痤疮丙酸杆菌是一种兼性厌氧革兰阳性杆菌,是包括口腔在内的体表共生细菌。痤疮丙酸杆菌与肉样瘤病和骨科植入物相关感染等慢性肉芽肿疾病之间存在因果关系。通常情况下,痤疮丙酸杆菌存在于巨噬细胞内,可以逃避宿主免疫,并引发持续的炎症反应。然而,在种植体周围炎病变中还没有此类发现的报道。在本病例系列中,我们从八名患者的广泛种植体周围炎病变中采集了炎性组织。在这 8 份样本中,7 份样本的痤疮丙酸杆菌 16 s rRNA 基因聚合酶链反应检测呈阳性,6 份样本的免疫组化检测呈阳性。免疫组化染色显示,巨噬细胞的细胞质中存在痤疮丙酸杆菌,这表明痤疮丙酸杆菌在病变形成过程中发挥了作用。这一发现可能会加深我们对持久性种植体周围炎病变的病理生理学的理解,并为今后的治疗提供借鉴。
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