Development of a spectroscopic mapping system for simultaneous analysis of biological functions and trace elements using ion microbeams

IF 1.4 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms Pub Date : 2024-08-13 DOI:10.1016/j.nimb.2024.165495

Makoto Nishizawa, Shigeo Matsuyama, Yohei Kikuchi, Sho Toyama, Misako Miwa, Wataru Kada

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Abstract

In order to investigate the correlation between biological functions and trace elements, we have developed a spectroscopic mapping system for ion beam induced fluorescence (IBIF) analysis using a spectrometer and a CCD-based spectrometer and a photon counting type spectrometer based on a multi-pixel photon counter (MPPC) array. Biological functions and trace elements are closely related. To study this relationship, biological functions and trace elements must be mapped to the same positional coordinates. Our new IBIF analysis system, developed at the Dynamitron Laboratory of Tohoku University, has a high-speed capability of detection of IBIF by the fast response of the MPPC and a better signal-to-noise ratio (SNR) of imaging capability by the detection of fluorescence induced by the proton microprobe. As an evaluation trial, the IBIF analysis of the phosphor of cathode ray tube TV samples was performed. It was shown that spectral mapping is possible with the developed system.

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利用离子微束开发同时分析生物功能和痕量元素的光谱绘图系统

为了研究生物功能与痕量元素之间的相关性，我们利用光谱仪和基于 CCD 的光谱仪以及基于多像素光子计数器（MPPC）阵列的光子计数型光谱仪，开发了一套用于离子束诱导荧光（IBIF）分析的光谱绘图系统。生物功能与微量元素密切相关。要研究这种关系，必须将生物功能和痕量元素映射到相同的位置坐标上。我们的新型 IBIF 分析系统是在东北大学 Dynamitron 实验室开发的，通过 MPPC 的快速反应实现了 IBIF 的高速检测能力，通过质子微探针诱导的荧光检测实现了更好的信噪比（SNR）成像能力。作为评估试验，对显像管电视样品的荧光粉进行了 IBIF 分析。结果表明，利用所开发的系统可以绘制光谱图。

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来源期刊

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms 物理-核科学技术

CiteScore

2.80

自引率

7.70%

发文量

231

审稿时长

1.9 months

期刊介绍： Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.