Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities
{"title":"Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities","authors":"","doi":"10.1016/j.polymdegradstab.2024.110940","DOIUrl":null,"url":null,"abstract":"<div><p>Polypropylene (PP) is widely used in the medical industry to produce syringes, vials, and numerous other single-use biopharmaceutical devices. The need to sterilize these products has led to intensive use of high-energy radiation, even though PP is known to undergo excessive oxidative degradation and deterioration in properties upon irradiation in air. In recent years, a shortage in <sup>60</sup>Co supply, as a main source for gamma sterilization, is pushing radiation sterilization of polymeric medical products to electron beam (EB) and/or X-ray modalities as preferable. Some questions related to the equivalence of these methods remain open and are mostly related to changes in the material structure caused by different types of radiation and processing conditions, such as dose rates.</p><p>This research compares electron beam and gamma irradiation modalities employed on the low crystalline (quenched) PP. In the case of EB irradiation, the typical dose rates are on the order of 10<sup>4</sup> kGy/h, while in the case of gamma radiation dose rates are lower for three or more orders of magnitude. Since gamma irradiation covers a wide range of dose rates, the difference between samples gamma irradiated with relatively fast (8 kGy/h) and slow (0.08 kGy/h) dose rates was also analyzed in detail. Comparative investigation of crystallinity, oxidative degradation, thermal, dielectric, and mechanical properties provide a clearer picture of the impact of different modalities and dose rates on mesomorphic PP and are of interest in the practical application of ionizing radiation in the sterilization of PP-based medical devices.</p></div>","PeriodicalId":406,"journal":{"name":"Polymer Degradation and Stability","volume":null,"pages":null},"PeriodicalIF":6.3000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Degradation and Stability","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0141391024002842","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Polypropylene (PP) is widely used in the medical industry to produce syringes, vials, and numerous other single-use biopharmaceutical devices. The need to sterilize these products has led to intensive use of high-energy radiation, even though PP is known to undergo excessive oxidative degradation and deterioration in properties upon irradiation in air. In recent years, a shortage in 60Co supply, as a main source for gamma sterilization, is pushing radiation sterilization of polymeric medical products to electron beam (EB) and/or X-ray modalities as preferable. Some questions related to the equivalence of these methods remain open and are mostly related to changes in the material structure caused by different types of radiation and processing conditions, such as dose rates.
This research compares electron beam and gamma irradiation modalities employed on the low crystalline (quenched) PP. In the case of EB irradiation, the typical dose rates are on the order of 104 kGy/h, while in the case of gamma radiation dose rates are lower for three or more orders of magnitude. Since gamma irradiation covers a wide range of dose rates, the difference between samples gamma irradiated with relatively fast (8 kGy/h) and slow (0.08 kGy/h) dose rates was also analyzed in detail. Comparative investigation of crystallinity, oxidative degradation, thermal, dielectric, and mechanical properties provide a clearer picture of the impact of different modalities and dose rates on mesomorphic PP and are of interest in the practical application of ionizing radiation in the sterilization of PP-based medical devices.
期刊介绍:
Polymer Degradation and Stability deals with the degradation reactions and their control which are a major preoccupation of practitioners of the many and diverse aspects of modern polymer technology.
Deteriorative reactions occur during processing, when polymers are subjected to heat, oxygen and mechanical stress, and during the useful life of the materials when oxygen and sunlight are the most important degradative agencies. In more specialised applications, degradation may be induced by high energy radiation, ozone, atmospheric pollutants, mechanical stress, biological action, hydrolysis and many other influences. The mechanisms of these reactions and stabilisation processes must be understood if the technology and application of polymers are to continue to advance. The reporting of investigations of this kind is therefore a major function of this journal.
However there are also new developments in polymer technology in which degradation processes find positive applications. For example, photodegradable plastics are now available, the recycling of polymeric products will become increasingly important, degradation and combustion studies are involved in the definition of the fire hazards which are associated with polymeric materials and the microelectronics industry is vitally dependent upon polymer degradation in the manufacture of its circuitry. Polymer properties may also be improved by processes like curing and grafting, the chemistry of which can be closely related to that which causes physical deterioration in other circumstances.