{"title":"Cellular senescence is required for cardiac regeneration","authors":"","doi":"10.1038/s44161-024-00494-0","DOIUrl":null,"url":null,"abstract":"We describe the regenerative senescence signature of the injured mouse heart using proteomics and single-cell RNA sequencing. We report that transient senescence is required for neonatal mouse heart regeneration and for agrin-mediated cardiac repair in adult mice and provide insights into the essential role of Egr1 in senescence and regeneration.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 8","pages":"897-898"},"PeriodicalIF":9.4000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00494-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
We describe the regenerative senescence signature of the injured mouse heart using proteomics and single-cell RNA sequencing. We report that transient senescence is required for neonatal mouse heart regeneration and for agrin-mediated cardiac repair in adult mice and provide insights into the essential role of Egr1 in senescence and regeneration.
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