Genotyping and Antiretroviral Drug Resistance Mutations among HIV Patients in Southern Santa Catarina, Brazil.

IF 0.8 4区医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2024-01-01 DOI:10.2174/011570162X296948240802075249

Chaiana Esmeraldino Mendes Marcon, Aline Daiane Schlindwein, Luis Fernando de Macedo Brigido, Giselle Ibette Lopez-Lopes, Gabriela Bastos Cabral, Fabiana Schuelter-Trevisol

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Abstract

Introduction: Therapeutic measures have been successful in increasing survival rates and quality of life of HIV/AIDS-infected people. However, some people fail to respond to antiretroviral therapy (HAART) because of viral resistance-associated mutations.

Objective: To identify virus genotype and the presence of mutations that alter the susceptibility to HAART, and factors associated with the occurrence of these mutations.

Methods: A cross-sectional study was conducted on adults living with HIV attending a specialized outpatient clinic in southern Santa Catarina, Brazil. The participants were interviewed and had blood samples collected for analysis. Those with detectable viral load were genotyped.

Results: Out of the 629 patients recruited, 127 subjects were included due to having a detectable viral load. The most common mutations were M184V and K103N. HIV-1 subtype C was the most prevalent strain. Resistance to HAART was associated with modification in the treatment regimen (p <0.001).

Conclusion: This study concluded that the circulating subtype virus was subtype C and that the mutations K103N and M184V were the most prevalent strains in southern Santa Catarina, Brazil.

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巴西圣卡塔琳娜州南部 HIV 患者的基因分型和抗逆转录病毒药物耐药性突变。

导言：治疗措施已成功提高了艾滋病毒/艾滋病感染者的存活率和生活质量。然而，由于病毒耐药性相关突变，一些患者对抗逆转录病毒疗法（HAART）无效：目的：确定病毒基因型、是否存在改变对 HAART 敏感性的变异，以及与发生这些变异相关的因素：对巴西圣卡塔琳娜州南部一家专科门诊的成年艾滋病病毒感染者进行了横断面研究。研究人员对参与者进行了访谈，并采集了血液样本进行分析。对检测到病毒载量的患者进行了基因分型：结果：在招募的 629 名患者中，127 人因可检测到病毒载量而被纳入研究。最常见的变异是 M184V 和 K103N。HIV-1 亚型 C 是最常见的病毒株。对 HAART 的耐药性与治疗方案的改变有关（P 结论：HAART 的耐药性与治疗方案的改变有关：本研究得出结论，流行的亚型病毒是 C 亚型，K103N 和 M184V 突变是巴西圣卡塔琳娜州南部最流行的病毒株。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.