Crustaceans played a primary role in establishing gamma-aminobutyric acid as a neurotransmitter

IF 5.8 1区农林科学 Q1 BIOLOGY Current opinion in insect science Pub Date : 2024-08-12 DOI:10.1016/j.cois.2024.101252

Edward A Kravitz , Saheli Sengupta

引用次数: 0

Abstract

Crustaceans played a major role in establishing that gamma-aminobutyric acid (GABA) functioned as an inhibitory transmitter compound. In fact, it is now widely accepted that GABA is the major inhibitory transmitter compound in all animal species where it has been examined. The story of its acceptance as a neurotransmitter, however, is more interesting than that. GABA was first isolated from mammalian brains by three laboratories in 1950. Great excitement surrounded this discovery, and many laboratories began exploring its function. This excitement peaked at two large international congresses in the United States at the end of the first decade of study, where a consensus of major figures in the field was that GABA was not a transmitter compound. How could this have happened?

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

甲壳动物在将 GABA 确立为神经递质方面发挥了主要作用。

甲壳类动物在确定γ-氨基丁酸（GABA）具有抑制性递质化合物的功能方面发挥了重要作用。事实上，现在人们普遍认为，在所有研究过 GABA 的动物物种中，GABA 都是主要的抑制性递质化合物。然而，GABA 被接受为神经递质的故事却比这更有趣。1950 年，3 个实验室首次从哺乳动物大脑中分离出 GABA。这一发现引起了极大的轰动，许多实验室开始探索它的功能。在研究的第一个十年结束时，在美国举行的两次大型国际会议上，这种兴奋达到了顶峰，会上该领域的主要人物一致认为 GABA 不是一种递质化合物。怎么会出现这种情况呢？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.