FTO gene polymorphism and susceptibility to polycystic ovary syndrome: A meta-analysis

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2024-08-14 DOI:10.1111/jog.16047

Chuanhua Zhang, Jiali Yu

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引用次数: 0

Abstract

Aim

To explore the correlation between Fat mass and objectivity associated gene (FTO) rs9939609 polymorphism and susceptibility to polycystic ovary syndrome.

Methods

Case–control studies on the relationship between FTO rs9939609 A/T polymorphism and PCOS were searched in PubMed, EMBASE, and Web of Science according to inclusion and exclusion criteria. STATA 12.0 software was conducted for Meta-analysis.

Results

Nine case–control studies were included, including 1410 cases in PCOS group and 1223 cases in healthy control group. The results of meta-analysis showed that FTO rs9939609 gene polymorphism was associated with PCOS susceptibility, and the risk of developing PCOS was 1.19 times higher for T alleles carriers than for A alleles carriers, and some similar associations were observed in Asian populations.

Conclusions

In summary, FTO rs9939609 gene polymorphism is significantly associated with PCOS susceptibility, especially in Asian populations.

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FTO 基因多态性与多囊卵巢综合征的易感性：荟萃分析

目的：探讨脂肪量和客观性相关基因（FTO）rs9939609多态性与多囊卵巢综合征易感性之间的相关性：根据纳入和排除标准，在 PubMed、EMBASE 和 Web of Science 中检索有关 FTO rs9939609 A/T 多态性与多囊卵巢综合征关系的病例对照研究。采用 STATA 12.0 软件进行 Meta 分析：结果：共纳入 9 项病例对照研究，其中 PCOS 组 1410 例，健康对照组 1223 例。荟萃分析结果显示，FTO rs9939609基因多态性与多囊卵巢综合征易感性相关，T等位基因携带者患多囊卵巢综合征的风险是A等位基因携带者的1.19倍，在亚洲人群中也观察到一些类似的关联：综上所述，FTO rs9939609基因多态性与多囊卵巢综合征易感性显著相关，尤其是在亚洲人群中。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.