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Awareness and attitude toward cardio-oncology among Japanese gynecologic oncologists in managing patients with endometrial cancer: The Japanese Gynecologic Oncology Group (JGOG) questionnaire surveys
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-05 DOI: 10.1111/jog.16225
Yoichi Kobayashi, Mikiko Asai-Sato, Shiho Kuji, Hitomi Sakai, Ken Yamaguchi, Nao Suzuki, Yoshio Yoshida

Aim

This study aimed to assess the awareness of the concept of “cardio-oncology” and cardiovascular disease (CVD) in patients with endometrial cancer (EC) among the Japanese Gynecologic Oncology Group members.

Methods

An online anonymous survey, which consisted of questions about respondent attributes and cardio-oncology, was conducted twice, in 2022 and 2024. During these surveys, guidelines for the treatment of uterine body neoplasm were published in July 2023.

Results

In 2022, significantly numerous physicians were unaware of cardio-oncology or the increased risk of developing CVD in patients with EC, and 25.3% of them answered that they had no idea about cardio-oncology at all. However, in 2024, the percentage significantly dropped to 8.7%. The number of physicians who were aware that CVD is more common as the cause of death in patients with low-grade EC than the cancer itself was significantly higher in 2024 than in 2022. Similarly, the number of physicians who were aware that the usage of platinum agents could become a risk factor for CVD was significantly higher in 2024. Furthermore, this study reported challenges in the collaboration between oncologists and primary care physicians in the region and in the provision of guidance for preventing metabolic syndrome.

Conclusion

Japanese Gynecologic Oncology Group members' awareness of cardio-oncology was inadequate, but it seemed to be improving, especially after publishing the guideline for the treatment of uterine body neoplasm. Thus, raising awareness of cardio-oncology and managing CVD risk in patients with EC are necessary to improve long-term survival after cancer diagnosis.

{"title":"Awareness and attitude toward cardio-oncology among Japanese gynecologic oncologists in managing patients with endometrial cancer: The Japanese Gynecologic Oncology Group (JGOG) questionnaire surveys","authors":"Yoichi Kobayashi,&nbsp;Mikiko Asai-Sato,&nbsp;Shiho Kuji,&nbsp;Hitomi Sakai,&nbsp;Ken Yamaguchi,&nbsp;Nao Suzuki,&nbsp;Yoshio Yoshida","doi":"10.1111/jog.16225","DOIUrl":"https://doi.org/10.1111/jog.16225","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to assess the awareness of the concept of “cardio-oncology” and cardiovascular disease (CVD) in patients with endometrial cancer (EC) among the Japanese Gynecologic Oncology Group members.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An online anonymous survey, which consisted of questions about respondent attributes and cardio-oncology, was conducted twice, in 2022 and 2024. During these surveys, guidelines for the treatment of uterine body neoplasm were published in July 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2022, significantly numerous physicians were unaware of cardio-oncology or the increased risk of developing CVD in patients with EC, and 25.3% of them answered that they had no idea about cardio-oncology at all. However, in 2024, the percentage significantly dropped to 8.7%. The number of physicians who were aware that CVD is more common as the cause of death in patients with low-grade EC than the cancer itself was significantly higher in 2024 than in 2022. Similarly, the number of physicians who were aware that the usage of platinum agents could become a risk factor for CVD was significantly higher in 2024. Furthermore, this study reported challenges in the collaboration between oncologists and primary care physicians in the region and in the provision of guidance for preventing metabolic syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Japanese Gynecologic Oncology Group members' awareness of cardio-oncology was inadequate, but it seemed to be improving, especially after publishing the guideline for the treatment of uterine body neoplasm. Thus, raising awareness of cardio-oncology and managing CVD risk in patients with EC are necessary to improve long-term survival after cancer diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of intra-amniotic colonization based on copy numbers of 16S ribosomal deoxyribonucleic acid: A diagnostic and prognostic study
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-05 DOI: 10.1111/jog.16223
Daichi Urushiyama, Chihiro Kiyoshima, Toyofumi Hirakawa, Mami Shibata, Shiori Imi, Masamitsu Kurakazu, Kohei Miyata, Takashi Setoue, Shinichiro Nagamitsu, Makoto Nomiyama, Kazuhiko Nakabayashi, Fusanori Yotsumoto, Kenichiro Hata, Shingo Miyamoto

Aim

This study aimed to assess amniotic fluid bacterial load using the copy number of 16S ribosomal deoxyribonucleic acid and to clarify its association with perinatal outcomes.

Methods

This retrospective diagnostic and prognostic study included 63 patients with preterm labor and suspected intra-amniotic infection who underwent amniocentesis before 34 weeks of gestation. We measured the copy number of 16S ribosomal deoxyribonucleic acid in 1 mL of amniotic fluid using droplet digital polymerase chain reaction and graded infections as Grade (G) 0, 1, 2, or 3. Case–control analysis was performed to compare G3 (N = 29), G1–2 (N = 18), and G0 (N = 17) patients. The main outcome measures were histologic chorioamnionitis, funisitis, and amniocentesis-to-delivery time windows.

Results

The frequency of histologic chorioamnionitis (Stage III) and funisitis was as follows: G3, 86% and 79%; G1–2, 28% and 56%; and G0, 0% and 6%, respectively. The rate of post-amniocentesis delivery within 1 and 2 days was as follows: G3, 62% and 83%; G1–2, 56% and 78%; G0, 13% and 25%, respectively. Comparisons between the G3 and G0 groups revealed significant differences in all criteria (p < 0.05). Additionally, significant differences were noted in pathological inflammatory findings between the G3 and G1–2 groups, as well as in all perinatal outcomes between the G1–2 and G0 groups (p < 0.05).

Conclusions

Our diagnostic method, based on the copy number of 16S ribosomal deoxyribonucleic acid, supports intra-amniotic colonization assessment, guiding clinical decisions regarding the timing of delivery and potentially informing antimicrobial interventions.

{"title":"Assessment of intra-amniotic colonization based on copy numbers of 16S ribosomal deoxyribonucleic acid: A diagnostic and prognostic study","authors":"Daichi Urushiyama,&nbsp;Chihiro Kiyoshima,&nbsp;Toyofumi Hirakawa,&nbsp;Mami Shibata,&nbsp;Shiori Imi,&nbsp;Masamitsu Kurakazu,&nbsp;Kohei Miyata,&nbsp;Takashi Setoue,&nbsp;Shinichiro Nagamitsu,&nbsp;Makoto Nomiyama,&nbsp;Kazuhiko Nakabayashi,&nbsp;Fusanori Yotsumoto,&nbsp;Kenichiro Hata,&nbsp;Shingo Miyamoto","doi":"10.1111/jog.16223","DOIUrl":"10.1111/jog.16223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to assess amniotic fluid bacterial load using the copy number of 16S ribosomal deoxyribonucleic acid and to clarify its association with perinatal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective diagnostic and prognostic study included 63 patients with preterm labor and suspected intra-amniotic infection who underwent amniocentesis before 34 weeks of gestation. We measured the copy number of 16S ribosomal deoxyribonucleic acid in 1 mL of amniotic fluid using droplet digital polymerase chain reaction and graded infections as Grade (G) 0, 1, 2, or 3. Case–control analysis was performed to compare G3 (<i>N</i> = 29), G1–2 (<i>N</i> = 18), and G0 (<i>N</i> = 17) patients. The main outcome measures were histologic chorioamnionitis, funisitis, and amniocentesis-to-delivery time windows.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The frequency of histologic chorioamnionitis (Stage III) and funisitis was as follows: G3, 86% and 79%; G1–2, 28% and 56%; and G0, 0% and 6%, respectively. The rate of post-amniocentesis delivery within 1 and 2 days was as follows: G3, 62% and 83%; G1–2, 56% and 78%; G0, 13% and 25%, respectively. Comparisons between the G3 and G0 groups revealed significant differences in all criteria (<i>p</i> &lt; 0.05). Additionally, significant differences were noted in pathological inflammatory findings between the G3 and G1–2 groups, as well as in all perinatal outcomes between the G1–2 and G0 groups (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our diagnostic method, based on the copy number of 16S ribosomal deoxyribonucleic acid, supports intra-amniotic colonization assessment, guiding clinical decisions regarding the timing of delivery and potentially informing antimicrobial interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum period according to Roy adaptation model: Assessment of fatigue, self-esteem, functional status, and dyadic adjustment
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-05 DOI: 10.1111/jog.16221
Ayşe Nur Ataş, Habibe Bay Özçalik, Nebahat Özerdoğan

Objective

The study was conducted to examine the relationship between fatigue, self-esteem, functional status, and dyadic adjustment in the postpartum period and the factors affecting them.

Methods

The study was designed in cross-sectional type. It was carried out in the postpartum follow-up clinic of a hospital in the Central Anatolian Region of Turkey between November 2021 and July 2022. Responses from a total of 328 mothers in the first 6 months postpartum were analyzed. Data were collected using a “Descriptive Information Form,” the “Chalder Fatigue Scale,” the “Rosenberg Self-Esteem Scale,” the “Inventory of Functional Status after Childbirth,” and the “Revised Dyadic Adjustment Scale.”

Results

The mean scores of the mothers participating in the study on the total Chalder fatigue scale, Rosenberg self-esteem scale, Inventory of functional status after childbirth, and Revised dyadic adjustment scale were 13.65 ± 6.13, 1.33 ± 1.33, 10.57 ± 2.02, and 51.51 ± 9.49, respectively. It was determined that fatigue had a positive effect and dyadic adjustment had a negative effect on the postpartum self-esteem levels of the mothers. The progress of the postpartum period affects the functional status of mothers positively and significantly.

Conclusions

According to the results of the research, the decrease in fatigue and the increase in dyadic adjustment in women positively affect the increase in self-esteem.

{"title":"Postpartum period according to Roy adaptation model: Assessment of fatigue, self-esteem, functional status, and dyadic adjustment","authors":"Ayşe Nur Ataş,&nbsp;Habibe Bay Özçalik,&nbsp;Nebahat Özerdoğan","doi":"10.1111/jog.16221","DOIUrl":"https://doi.org/10.1111/jog.16221","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The study was conducted to examine the relationship between fatigue, self-esteem, functional status, and dyadic adjustment in the postpartum period and the factors affecting them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was designed in cross-sectional type. It was carried out in the postpartum follow-up clinic of a hospital in the Central Anatolian Region of Turkey between November 2021 and July 2022. Responses from a total of 328 mothers in the first 6 months postpartum were analyzed. Data were collected using a “Descriptive Information Form,” the “Chalder Fatigue Scale,” the “Rosenberg Self-Esteem Scale,” the “Inventory of Functional Status after Childbirth,” and the “Revised Dyadic Adjustment Scale.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean scores of the mothers participating in the study on the total Chalder fatigue scale, Rosenberg self-esteem scale, Inventory of functional status after childbirth, and Revised dyadic adjustment scale were 13.65 ± 6.13, 1.33 ± 1.33, 10.57 ± 2.02, and 51.51 ± 9.49, respectively. It was determined that fatigue had a positive effect and dyadic adjustment had a negative effect on the postpartum self-esteem levels of the mothers. The progress of the postpartum period affects the functional status of mothers positively and significantly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>According to the results of the research, the decrease in fatigue and the increase in dyadic adjustment in women positively affect the increase in self-esteem.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What's the difference between human-written manuscripts versus ChatGPT-generated manuscripts involving “human touch”?
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-05 DOI: 10.1111/jog.16226
Shigeki Matsubara, Daisuke Matsubara

Aim

To determine whether ChatGPT generates a manuscript with a “human touch” with appropriate inputs, and if yes, what's the difference between human writing versus ChatGPT writing. This is because the presence or absence of human touch may characterize human writing.

Methods

A descriptive study. The first author wrote a Disagreement Letter (Letter 1). Then, disagreement points and “human touch” were provided as input into ChatGPT-4 and tasked with generating a Letter (Letter 2). The authors, seven experienced researchers, and ChatGPT evaluated the readability of Letters 1 and 2.

Results

The authors, researchers, and ChatGPT, all reached the same conclusions: the human-written Letter 1 and the ChatGPT-generated Letter 2 had similar readability and similarly involved human touch. Some researchers and ChatGPT recognized slight differences in formal or informal and personal or nonpersonal tones between them, which they considered may not affect paper acceptance.

Conclusions

Human touch is not humans' exclusive possession. The distinction between the human writing versus ChatGPT writing is considered to be present not in the output (manuscript) but in the process of writing, that is, the presence or absence of a joy of writing. Artificial intelligence should aid in enhancing, or at the very least, not impede the human joy. This discussion deserves ongoing exploration.

{"title":"What's the difference between human-written manuscripts versus ChatGPT-generated manuscripts involving “human touch”?","authors":"Shigeki Matsubara,&nbsp;Daisuke Matsubara","doi":"10.1111/jog.16226","DOIUrl":"https://doi.org/10.1111/jog.16226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine whether ChatGPT generates a manuscript with a “human touch” with appropriate inputs, and if yes, what's the difference between human writing versus ChatGPT writing. This is because the presence or absence of human touch may characterize human writing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive study. The first author wrote a Disagreement Letter (Letter 1). Then, disagreement points and “human touch” were provided as input into ChatGPT-4 and tasked with generating a Letter (Letter 2). The authors, seven experienced researchers, and ChatGPT evaluated the readability of Letters 1 and 2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The authors, researchers, and ChatGPT, all reached the same conclusions: the human-written Letter 1 and the ChatGPT-generated Letter 2 had similar readability and similarly involved human touch. Some researchers and ChatGPT recognized slight differences in formal or informal and personal or nonpersonal tones between them, which they considered may not affect paper acceptance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Human touch is not humans' exclusive possession. The distinction between the human writing versus ChatGPT writing is considered to be present not in the output (manuscript) but in the process of writing, that is, the presence or absence of a joy of writing. Artificial intelligence should aid in enhancing, or at the very least, not impede the human joy. This discussion deserves ongoing exploration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-31 DOI: 10.1111/jog.16222
Ezgi Başaran, Fatma Doğa Öcal, Atakan Tanaçan, Zahid Ağaoğlu, Göksun Ipek, Betül Akgün Aktaş, Dilek Şahin

Aim

To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).

Methods

In this prospective case–control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (n: 30) and the control group (n: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.

Results

The AoI diameter was 4.8 ± 0.95 mm in the ICP group and 4.2 ± 0.62 mm in the control group, indicating a statistically significant difference (p = 0.003). The AoI Doppler flow parameters did not significantly differ between the groups (p > 0.05). When evaluated in subgroups according to disease severity, the AoI diameter and Doppler measurements did not significantly differ between the mild and severe ICP cases (p > 0.05). The AoI diameter was significantly larger in those requiring admission to the neonatal intensive care unit (NICU) (p = 0.005). This diameter was also larger in patients with fetal distress, albeit with no statistically significant difference (p = 0.65).

Conclusions

ICP is a pathology with known adverse fetal cardiac effects, but there is no effective method to predict adverse perinatal outcomes. The enlarged AoI diameter in the fetuses of mothers with ICP and the association of this enlargement with NICU requirements are important findings of this study. Further research with a larger number of patients is necessary to evaluate the clinical utility of fetal AoI diameter and Doppler parameters in ICP.

{"title":"Evaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?","authors":"Ezgi Başaran,&nbsp;Fatma Doğa Öcal,&nbsp;Atakan Tanaçan,&nbsp;Zahid Ağaoğlu,&nbsp;Göksun Ipek,&nbsp;Betül Akgün Aktaş,&nbsp;Dilek Şahin","doi":"10.1111/jog.16222","DOIUrl":"10.1111/jog.16222","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective case–control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (<i>n</i>: 30) and the control group (<i>n</i>: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The AoI diameter was 4.8 ± 0.95 mm in the ICP group and 4.2 ± 0.62 mm in the control group, indicating a statistically significant difference (<i>p</i> = 0.003). The AoI Doppler flow parameters did not significantly differ between the groups (<i>p</i> &gt; 0.05). When evaluated in subgroups according to disease severity, the AoI diameter and Doppler measurements did not significantly differ between the mild and severe ICP cases (<i>p</i> &gt; 0.05). The AoI diameter was significantly larger in those requiring admission to the neonatal intensive care unit (NICU) (<i>p</i> = 0.005). This diameter was also larger in patients with fetal distress, albeit with no statistically significant difference (<i>p</i> = 0.65).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ICP is a pathology with known adverse fetal cardiac effects, but there is no effective method to predict adverse perinatal outcomes. The enlarged AoI diameter in the fetuses of mothers with ICP and the association of this enlargement with NICU requirements are important findings of this study. Further research with a larger number of patients is necessary to evaluate the clinical utility of fetal AoI diameter and Doppler parameters in ICP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal cardiovascular dynamics in twin pregnancies complicated by twin-to-twin transfusion syndrome
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-31 DOI: 10.1111/jog.16224
Hikari Kotaki, Mayu Tachihara, Mio Kamiya, Makiko Shimabukuro, Junya Sakuma, Mayumi Takano, Sumito Nagasaki, Hiroshi Ohara, Masahiko Nakata

Aim

Twin pregnancies affect maternal circulation by increasing the circulating blood volume and enlarging the uterus due to excess amniotic fluid. Nevertheless, how twin-to-twin transfusion syndrome (TTTS) affects maternal circulation remains unclear. Our aim was to examine maternal circulation changes at TTTS onset.

Methods

This cohort study was conducted at the Toho University Omori Medical Center from October 2022 to September 2023. Patients were divided into three groups, singleton pregnancy (singleton), uncomplicated monochorionic diamniotic (MD) twin pregnancy (nMD), and TTTS groups. We prospectively collected echocardiographic data to evaluate the left ventricular function, left ventricular contractility, diastolic performance, and inferior vena cava diameter.

Results

Thirty-one, 17, and 18 patients were assigned to the singleton, nMD, and TTTS groups, respectively. The left ventricular end-systolic volume (ESV) was significantly lower in the TTTS group than in the nMD group [ESV: 23.9 ± 9.2 mL vs. 13.3 ± 8.4 mL]. The left ventricular end-diastolic volume (EDV) was no significant difference, but a decreasing trend in the TTTS group than in the nMD group. The left ventricular ejection fraction was significantly lower in the nMD group than in the TTTS group [72.2 ± 6.4% vs. 80.1 ± 5.9%]. The heart rate was significantly higher in the TTTS group than in the other two groups. Cardiac output was similar among the groups.

Conclusions

MD twin pregnancy with TTTS may decrease circulating blood volumes. Maternal cardiac function may be adapted to compensate for cardiac output in patients with TTTS.

{"title":"Maternal cardiovascular dynamics in twin pregnancies complicated by twin-to-twin transfusion syndrome","authors":"Hikari Kotaki,&nbsp;Mayu Tachihara,&nbsp;Mio Kamiya,&nbsp;Makiko Shimabukuro,&nbsp;Junya Sakuma,&nbsp;Mayumi Takano,&nbsp;Sumito Nagasaki,&nbsp;Hiroshi Ohara,&nbsp;Masahiko Nakata","doi":"10.1111/jog.16224","DOIUrl":"10.1111/jog.16224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Twin pregnancies affect maternal circulation by increasing the circulating blood volume and enlarging the uterus due to excess amniotic fluid. Nevertheless, how twin-to-twin transfusion syndrome (TTTS) affects maternal circulation remains unclear. Our aim was to examine maternal circulation changes at TTTS onset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study was conducted at the Toho University Omori Medical Center from October 2022 to September 2023. Patients were divided into three groups, singleton pregnancy (singleton), uncomplicated monochorionic diamniotic (MD) twin pregnancy (nMD), and TTTS groups. We prospectively collected echocardiographic data to evaluate the left ventricular function, left ventricular contractility, diastolic performance, and inferior vena cava diameter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-one, 17, and 18 patients were assigned to the singleton, nMD, and TTTS groups, respectively. The left ventricular end-systolic volume (ESV) was significantly lower in the TTTS group than in the nMD group [ESV: 23.9 ± 9.2 mL vs. 13.3 ± 8.4 mL]. The left ventricular end-diastolic volume (EDV) was no significant difference, but a decreasing trend in the TTTS group than in the nMD group. The left ventricular ejection fraction was significantly lower in the nMD group than in the TTTS group [72.2 ± 6.4% vs. 80.1 ± 5.9%]. The heart rate was significantly higher in the TTTS group than in the other two groups. Cardiac output was similar among the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MD twin pregnancy with TTTS may decrease circulating blood volumes. Maternal cardiac function may be adapted to compensate for cardiac output in patients with TTTS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fresh frozen plasma, fibrinogen concentrate, and antithrombin concentrate administration for obstetrical disseminated intravascular coagulation by the Japanese previous and new criteria
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-29 DOI: 10.1111/jog.16220
Mamoru Morikawa, Shigetaka Matsunaga, Shintaro Makino, Yoshiharu Takeda, Hironobu Hyodo, Masafumi Nii, Mariko Serizawa, Eriko Eto, Jun Takeda, Tomoko Adachi, Takao Kobayashi, Atsuo Itakura

Aim

The purpose of this study is to clarify the frequencies of fresh frozen plasma (FFP) ± fibrinogen concentrate administration (fibrinogen concentrate [FC] therapy) and antithrombin (AT) concentrate administration (AT therapy) for the women with obstetrical disseminated intravascular coagulation (DIC).

Methods

Two retrospective multicenter case–control studies as Study-1 (January–December 2018) and Study-2 (July 2022–June 2023) were conducted. Study-1 was the historical control of Study-2. All participants experienced a blood loss of ≥1000 mL during vaginal delivery or ≥2000 mL during cesarean section. All participants were subsequently assigned to the DIC group or non-DIC group.

Results

Study-1 comprised 175 women (obstetrical DIC, 27; control, 148; by the previous criteria) and Study-2 comprised 175 women (obstetrical DIC, 9; control, 166; by the new criteria). The frequencies of FFP (±FC therapy) or FC therapy in DIC group were significantly higher than non-DIC group in Study-1 (88.9% vs. 25.0%, 44.4% vs. 4.0%) and Study-2 (100% vs. 24.7%, 77.8% vs. 5.4%); however, the frequencies of AT therapy were similar. Furthermore, in the DIC group, all women with fibrinogen <150 mg/dL received FFP ± FC therapy in Study-1 (n = 19) and Study-2 (n = 8); however, those with AT activity <70% received AT therapy (16.7% [4/24] and 12.5% [1/8], respectively).

Conclusion

We revealed an association between the high frequency of FFP ± FC therapy and lower fibrinogen levels, but a low frequency of AT therapy regardless of AT activity, in obstetrical DIC regardless of diagnosis criteria.

{"title":"Fresh frozen plasma, fibrinogen concentrate, and antithrombin concentrate administration for obstetrical disseminated intravascular coagulation by the Japanese previous and new criteria","authors":"Mamoru Morikawa,&nbsp;Shigetaka Matsunaga,&nbsp;Shintaro Makino,&nbsp;Yoshiharu Takeda,&nbsp;Hironobu Hyodo,&nbsp;Masafumi Nii,&nbsp;Mariko Serizawa,&nbsp;Eriko Eto,&nbsp;Jun Takeda,&nbsp;Tomoko Adachi,&nbsp;Takao Kobayashi,&nbsp;Atsuo Itakura","doi":"10.1111/jog.16220","DOIUrl":"10.1111/jog.16220","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study is to clarify the frequencies of fresh frozen plasma (FFP) ± fibrinogen concentrate administration (fibrinogen concentrate [FC] therapy) and antithrombin (AT) concentrate administration (AT therapy) for the women with obstetrical disseminated intravascular coagulation (DIC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two retrospective multicenter case–control studies as Study-1 (January–December 2018) and Study-2 (July 2022–June 2023) were conducted. Study-1 was the historical control of Study-2. All participants experienced a blood loss of ≥1000 mL during vaginal delivery or ≥2000 mL during cesarean section. All participants were subsequently assigned to the DIC group or non-DIC group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Study-1 comprised 175 women (obstetrical DIC, 27; control, 148; by the previous criteria) and Study-2 comprised 175 women (obstetrical DIC, 9; control, 166; by the new criteria). The frequencies of FFP (±FC therapy) or FC therapy in DIC group were significantly higher than non-DIC group in Study-1 (88.9% vs. 25.0%, 44.4% vs. 4.0%) and Study-2 (100% vs. 24.7%, 77.8% vs. 5.4%); however, the frequencies of AT therapy were similar. Furthermore, in the DIC group, all women with fibrinogen &lt;150 mg/dL received FFP ± FC therapy in Study-1 (<i>n</i> = 19) and Study-2 (<i>n</i> = 8); however, those with AT activity &lt;70% received AT therapy (16.7% [4/24] and 12.5% [1/8], respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We revealed an association between the high frequency of FFP ± FC therapy and lower fibrinogen levels, but a low frequency of AT therapy regardless of AT activity, in obstetrical DIC regardless of diagnosis criteria.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sleep problems during pregnancy and postpartum depressive symptoms as well as condition of newborn at delivery
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-26 DOI: 10.1111/jog.16219
Yoko Komada, Sho-Ichi Kawakami, Satoko Furuie, Rena Mori, Azusa Ikegami

Background

Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. The relationship between sleep problems during pregnancy and postpartum depressive symptoms as well as neonatal condition at delivery have not been well described. This study hypothesized that sleep problems are associated with postpartum depressive symptoms and adverse neonatal outcomes at delivery.

Methods

This study conducted a prospective study for perinatal women (n = 683, 30.54 ± 5.11 years old) to evaluate sleep problems during pregnancy using the Pittsburgh sleep quality index (PSQI) and Berlin questionnaire, postpartum depressive symptoms using Edinburgh postnatal depression scale (EPDS), and clinical signs of neonatal condition at delivery using the Apgar score.

Results

PSQI total score during pregnancy were significantly higher in those with postpartum depressive symptoms than those without 1 month after delivery. PSQI score in the third trimester was significantly associated with postpartum depressive symptoms even after adjustment for relevant confounding factors and self-reported lifetime depression (odds ratio = 1.19, 95% confidence interval = 1.03–1.36, p = 0.015). The Apgar score at 5 min after birth was significantly lower in those with obstructive sleep apnea (OSA) than those without OSA in the second and third trimesters, although mean scores were within the normal range.

Conclusion

This study revealed that sleep problems during pregnancy influence postpartum depression 1 month after delivery. OSA during pregnancy may lead to risks of delivery. Attention should be paid to sleep health during pregnancy to ensure the mental health of mothers and a safe delivery.

{"title":"Association between sleep problems during pregnancy and postpartum depressive symptoms as well as condition of newborn at delivery","authors":"Yoko Komada,&nbsp;Sho-Ichi Kawakami,&nbsp;Satoko Furuie,&nbsp;Rena Mori,&nbsp;Azusa Ikegami","doi":"10.1111/jog.16219","DOIUrl":"10.1111/jog.16219","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. The relationship between sleep problems during pregnancy and postpartum depressive symptoms as well as neonatal condition at delivery have not been well described. This study hypothesized that sleep problems are associated with postpartum depressive symptoms and adverse neonatal outcomes at delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study conducted a prospective study for perinatal women (<i>n</i> = 683, 30.54 ± 5.11 years old) to evaluate sleep problems during pregnancy using the Pittsburgh sleep quality index (PSQI) and Berlin questionnaire, postpartum depressive symptoms using Edinburgh postnatal depression scale (EPDS), and clinical signs of neonatal condition at delivery using the Apgar score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PSQI total score during pregnancy were significantly higher in those with postpartum depressive symptoms than those without 1 month after delivery. PSQI score in the third trimester was significantly associated with postpartum depressive symptoms even after adjustment for relevant confounding factors and self-reported lifetime depression (odds ratio = 1.19, 95% confidence interval = 1.03–1.36, <i>p</i> = 0.015). The Apgar score at 5 min after birth was significantly lower in those with obstructive sleep apnea (OSA) than those without OSA in the second and third trimesters, although mean scores were within the normal range.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study revealed that sleep problems during pregnancy influence postpartum depression 1 month after delivery. OSA during pregnancy may lead to risks of delivery. Attention should be paid to sleep health during pregnancy to ensure the mental health of mothers and a safe delivery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of textbook oncologic outcome after neoadjuvant chemotherapy and interval debulking surgery for advanced ovarian cancer
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-23 DOI: 10.1111/jog.16218
Jiayin Yu, Yiyang Wang, Liqun Liu, Yaolong Xiao, Gang Yu

Aim

To examine the prognostic impact of textbook oncologic outcome (TOO) in patients with advanced ovarian cancer undergoing primary chemotherapy, along with identifying the risk factors for TOO failure.

Methods

Patients who underwent neoadjuvant chemotherapy followed by interval debulking surgery for advanced ovarian cancer at a tertiary center between 2014 and 2019 were retrospectively reviewed. TOO was defined as complete cytoreduction, no severe complications, no prolonged hospital stay, no readmission, no delayed initiation of adjuvant chemotherapy, and no 90-day mortality. The associations between TOO and clinical characteristics (survival) were examined using logistic and Cox regression analyses.

Results

Among 165 patients, 65 (39.4%) achieved TOO. The most common reason for TOO failure was incomplete cytoreduction (n = 46, 27.9%). Older age (p = 0.049) and visceral obesity (p = 0.030) were independently associated with TOO failure. Patients who achieved TOO had significantly prolonged overall survival (OS; median: 52 vs. 31 months, p = 0.010) and progression-free survival (PFS; median: not reached vs. 19 months, p = 0.006) compared to those who did not achieve TOO. Multivariate analysis revealed that TOO achievement was an independent protective factor for OS (hazard ratio [HR] 0.591, 95% confidence interval [CI] 0.387–0.905, p = 0.015) and PFS (HR 0.626, 95% CI 0.410–0.956, p = 0.030).

Conclusions

TOO is an effective predictor of favorable outcomes in patients with advanced ovarian cancer undergoing interval debulking surgery. Factors such as older age and visceral obesity may hinder the achievement of TOO.

{"title":"Assessment of textbook oncologic outcome after neoadjuvant chemotherapy and interval debulking surgery for advanced ovarian cancer","authors":"Jiayin Yu,&nbsp;Yiyang Wang,&nbsp;Liqun Liu,&nbsp;Yaolong Xiao,&nbsp;Gang Yu","doi":"10.1111/jog.16218","DOIUrl":"10.1111/jog.16218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the prognostic impact of textbook oncologic outcome (TOO) in patients with advanced ovarian cancer undergoing primary chemotherapy, along with identifying the risk factors for TOO failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent neoadjuvant chemotherapy followed by interval debulking surgery for advanced ovarian cancer at a tertiary center between 2014 and 2019 were retrospectively reviewed. TOO was defined as complete cytoreduction, no severe complications, no prolonged hospital stay, no readmission, no delayed initiation of adjuvant chemotherapy, and no 90-day mortality. The associations between TOO and clinical characteristics (survival) were examined using logistic and Cox regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 165 patients, 65 (39.4%) achieved TOO. The most common reason for TOO failure was incomplete cytoreduction (<i>n</i> = 46, 27.9%). Older age (<i>p</i> = 0.049) and visceral obesity (<i>p</i> = 0.030) were independently associated with TOO failure. Patients who achieved TOO had significantly prolonged overall survival (OS; median: 52 vs. 31 months, <i>p</i> = 0.010) and progression-free survival (PFS; median: not reached vs. 19 months, <i>p</i> = 0.006) compared to those who did not achieve TOO. Multivariate analysis revealed that TOO achievement was an independent protective factor for OS (hazard ratio [HR] 0.591, 95% confidence interval [CI] 0.387–0.905, <i>p</i> = 0.015) and PFS (HR 0.626, 95% CI 0.410–0.956, <i>p</i> = 0.030).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TOO is an effective predictor of favorable outcomes in patients with advanced ovarian cancer undergoing interval debulking surgery. Factors such as older age and visceral obesity may hinder the achievement of TOO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women's health care committee, Japan Society of Obstetrics and Gynecology: Annual report—2024 日本妇产科学会妇女保健委员会:年度报告-2024。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-01-22 DOI: 10.1111/jog.16192
Tsuyoshi Higuchi, Takeshi Iwasa

The Women's Health Care Committee was established in 2010 to improve the health of women. In the current academic year, this committee established seven subcommittees aimed at understanding diseases related to various age groups of women, including adolescence, sexual maturity, and menopause, and promoting research to improve the quality of life. Additionally, socially significant research has focused on infections, particularly resistant bacteria. The activities of each subcommittee are described. This report is based on the Japanese version of the annual report (Acta Obst Gynaec Jpn 2024;76(6):682–87).

妇女保健委员会于2010年成立,旨在改善妇女的健康状况。在本学年,该委员会成立了七个小组委员会,旨在了解与不同年龄组妇女有关的疾病,包括青春期、性成熟期和更年期,并促进研究以提高生活质量。此外,具有社会意义的研究集中在感染上,特别是耐药细菌。描述了每个小组委员会的活动。本报告基于年度报告的日文版本(Acta Obst Gynaec Jpn 2024;76(6):682-87)。
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引用次数: 0
期刊
Journal of Obstetrics and Gynaecology Research
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