Single-cell encapsulation systems for probiotic delivery: Armor probiotics

IF 15.9 1区 化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-08-06 DOI:10.1016/j.cis.2024.103270
Runan Zhao , Ting Yu , Jiaheng Li , Ruihao Niu , Donghong Liu , Wenjun Wang
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Abstract

Functional foods or drugs based on probiotics have gained unprecedented attention and development due to the increasingly clear relationship between probiotics and human health. Probiotics can regulate intestinal microbiota, dynamically participating in various physiological activities to directly affect human health. Some probiotic-based functional preparations have shown great potential in treating multiple refractory diseases. Currently, the survival and activity of probiotic cells in complex environments in vitro and in vivo have taken priority, and various encapsulation systems based on food-derived materials have been designed and constructed to protect and deliver probiotics. However, traditional encapsulation technology cannot achieve precise protection for a single probiotic, which makes it unable to have a significant effect after release. In this case, single-cell encapsulation systems can be assembled based on biological interfaces to protect and functionalize individual probiotic cells, maximizing their physiological activity. This review discussed the arduous challenges of probiotics in food processing, storage, human digestion, and the commonly used probiotic encapsulation system. Besides, a novel technology of probiotic encapsulation was introduced based on single-cell coating, namely, “armor probiotics”. We focused on the classification, structural design, and functional characteristics of armor coatings, and emphasized the essential functional characteristics of armor probiotics in human health regulation, including regulating intestinal health and targeted bioimaging and treatment of diseased tissues. Subsequently, the benefits, limitations, potential challenges, as well as future direction of armor probiotics were put forward. We hope this review may provide new insights and ideas for developing a single-cell probiotics encapsulating system.

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用于输送益生菌的单细胞封装系统:铠甲益生菌。
由于益生菌与人类健康之间的关系日益明确,以益生菌为基础的功能食品或药物得到了前所未有的关注和发展。益生菌可以调节肠道微生物群,动态参与各种生理活动,直接影响人体健康。一些基于益生菌的功能制剂在治疗多种难治性疾病方面显示出巨大潜力。目前,益生菌细胞在体外和体内复杂环境中的存活和活性已成为优先考虑的问题,人们设计和构建了各种基于食品衍生材料的封装系统,以保护和输送益生菌。然而,传统的封装技术无法实现对单个益生菌的精确保护,因而在释放后无法产生显著效果。在这种情况下,可以根据生物界面组装单细胞封装系统,对单个益生菌细胞进行保护和功能化,最大限度地发挥其生理活性。这篇综述讨论了益生菌在食品加工、储存、人体消化过程中面临的艰巨挑战,以及常用的益生菌封装系统。此外,还介绍了一种基于单细胞包衣的新型益生菌封装技术,即 "铠甲益生菌"。我们重点介绍了铠甲涂层的分类、结构设计和功能特点,强调了铠甲益生菌在人体健康调控方面的基本功能特点,包括调节肠道健康和对病变组织进行靶向生物成像和治疗。随后,提出了铠甲益生菌的益处、局限性、潜在挑战以及未来发展方向。我们希望这篇综述能为开发单细胞益生菌封装系统提供新的见解和思路。
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来源期刊
CiteScore
28.50
自引率
2.60%
发文量
175
审稿时长
31 days
期刊介绍: "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.
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