Relation of the intense physical exercise and asprosin concentrations in type 2 diabetic rats

IF 2.5 4区生物学 Q1 ANATOMY & MORPHOLOGY Tissue & cell Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI:10.1016/j.tice.2024.102501

Muzaffer Katar , Fikret Gevrek

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Abstract

Aim

Asprosin, a protein hormone, is released by unilocular adipocytes in reaction to low blood sugar. We aimed to examine how exercise affects asprosin hormone levels and associated organs, including the liver and pancreas, in diabetes.

Methods

Twenty-one male Wistar albino rats were firstly allocated into two main groups: control (n = 7) and diabetes (n = 14). Then, the diabetes group was further separated into two subgroups: sedentary (n = 7) and exercise (n = 7). The exercise group participated in a swimming training regimen (30 min/daily, six weeks). Serum levels of asprosin and various other biochemical parameters were evaluated through commercial ELISA kits. The liver was analyzed histopathologically, and pancreatic islet cells were examined for Cas-3 immune expression.

Results

Asprosin and total oxidant status decreased significantly in the exercise diabetic subgroup (p < 0.05). Glucose, insulin, creatinine, IL-6, and HomaIR concentrations decreased slightly with exercise (p > 0.05). Liver tissue injury scores and Cas-3 immune expression in pancreas islet cells decreased in exercise diabetic rats.

Conclusions

Reducing asprosin may lower glucose, insulin, and HOMA-IR. Physical activity decreases asprosin and total oxidative status, fostering anti-apoptosis and tissue healing in diabetes, potentially enhancing health. Monitoring asprosin levels offers insights into diabetes progression. Our findings imply that asprosin can be a therapeutic target for diabetes.

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剧烈运动与 2 型糖尿病大鼠体内阿司匹林浓度的关系

目的阿司匹林是一种蛋白质激素，由单眼脂肪细胞在低血糖时释放。方法首先将 21 只雄性 Wistar 白化大鼠分为两大组：对照组（7 只）和糖尿病组（14 只）。然后，糖尿病组又分为两个亚组：久坐组（7 只）和运动组（7 只）。运动组参加游泳训练（30 分钟/天，六周）。通过商用酶联免疫吸附试剂盒对血清中的阿司匹林水平和其他各种生化参数进行了评估。对肝脏进行了组织病理学分析，并检测了胰岛细胞的 Cas-3 免疫表达。葡萄糖、胰岛素、肌酐、IL-6 和 HomaIR 浓度随运动量的增加而略有下降（p > 0.05）。结论降低天冬氨酸可降低血糖、胰岛素和 HOMA-IR。体育锻炼可降低rosin和总氧化状态，促进糖尿病患者的抗凋亡和组织愈合，从而增强体质。监测rospin水平有助于深入了解糖尿病的进展情况。我们的研究结果表明，asprosin 可以成为糖尿病的治疗靶点。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.