Long-chain n-3 polyunsaturated fatty acid supplementation and neuromuscular function in older adults.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI:10.1097/MCO.0000000000001065

Oliver Hayman, Emilie Combet, Oliver C Witard, Stuart R Gray

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Abstract

Purpose of review: This review aims to explore the latest research investigating the effects of marine-derived long-chain n -3 polyunsaturated fatty acid (LC n -3 PUFA) supplementation on neuromuscular function in older adults.

Recent findings: Ageing results in a decline in skeletal muscle strength and mass. There is growing evidence that LC n -3 PUFA supplementation increases muscle strength and mass in healthy older adults, yet the mechanisms underlying these effects remain elusive. Recent studies investigating LC n -3 PUFA supplementation have demonstrated effects on neuromuscular function such as increases in the compound muscle action potential (M-wave) amplitude and surface electromyography alongside increases in muscular strength. Therefore, evidence suggests that LC n -3 PUFA may elicit a beneficial effect at the neuromuscular junction and possess neuroprotective properties in older adults.

Summary: LC n -3 PUFA supplementation may increase or maintain neuromuscular function throughout the ageing process. Further research is warranted to investigate the long-term effects LC n -3 PUFA supplementation on neuromuscular outcomes such as single motor unit properties and cortical/supraspinal networks, utilizing state-of-the-art techniques in neuromuscular physiology.

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补充长链 n-3 多不饱和脂肪酸与老年人的神经肌肉功能。

综述目的：本综述旨在探讨海洋萃取的长链 n-3 多不饱和脂肪酸（LCn-3 PUFA）补充剂对老年人神经肌肉功能影响的最新研究：最新研究结果：衰老会导致骨骼肌力量和质量下降。越来越多的证据表明，补充 LCn-3 PUFA 可增加健康老年人的肌肉力量和质量，但这些作用的机制仍不明确。最近对补充 LCn-3 PUFA 的研究表明，LCn-3 PUFA 对神经肌肉功能有影响，如复合肌肉动作电位（M 波）振幅和表面肌电图增加，同时肌肉力量增加。因此，有证据表明，LCn-3 PUFA 可能会对老年人的神经肌肉接头产生有益影响，并具有神经保护特性。有必要利用神经肌肉生理学的最新技术，进一步研究补充 LCn-3 PUFA 对神经肌肉功能的长期影响，如单个运动单位特性和皮层/脊髓上网络。

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来源期刊

Current Opinion in Clinical Nutrition and Metabolic Care 医学-内分泌学与代谢

CiteScore

5.30

自引率

6.50%

发文量

116

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.