Serum Cortisol and Blood Glucose Concentrations in Anesthetized Dogs Administered Levobupivacaine and Low-Dose Dexmedetomidine for Regional Anesthesia of the Oral Cavity.

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES Journal of Veterinary Dentistry Pub Date : 2024-08-16 DOI:10.1177/08987564241270598
Matic Pavlica, Mojca Kržan, Ana Nemec, Marija Nemec, Anže Baš, Tina Kosjek, Alenka Seliškar
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Abstract

The effects on the stress response, postanesthetic sedation, and altered behavior were evaluated following regional anesthesia and dental treatment in 40 dogs. Serum cortisol and blood glucose concentrations were measured following the administration of levobupivacaine (LBUP) 0.5% and dexmedetomidine (DEX) (0.5 µg/kg) or a placebo. The dogs were randomly assigned to 4 groups of 10 dogs each. All dogs received a regional nerve block using LBUP 0.5%. Group 1 (LBUP + DEX IV) also received DEX intravenously (IV); group 2 (LBUP + PLC IV) also received a placebo IV; group 3 (LBUP + DEX IO) also received DEX in one infraorbital (IO) block; and group 4 (LBUP + DEX IA) also received DEX in one inferior alveolar (IA) block. Serum cortisol and blood glucose concentrations were determined before the administration of oral blocks and at the end of the procedure. Sedation and behavior scores were assessed before premedication and hourly for 6 h after the end of anesthesia. Cortisol concentration did not change in any group at either evaluation time. The glucose concentration was higher (P < .05) only in the LBUP + DEX IA group at the end of the procedure. The sedation score was higher until the end of the observation period only in the LBUP + DEX IV and LBUP + PLC IV groups. No change in behavior score was observed in any of the groups. The reduction of perioperative stress response in all groups was due to the use of LBUP and not DEX.

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口腔区域麻醉时给麻醉犬注射左旋布比卡因和小剂量右美托咪定的血清皮质醇和血糖浓度。
我们对 40 只狗进行区域麻醉和牙科治疗后的应激反应、麻醉后镇静和行为改变的影响进行了评估。在使用 0.5% 左布比卡因 (LBUP) 和右美托咪定 (DEX) (0.5 µg/kg)或安慰剂后,测量了血清皮质醇和血糖浓度。这些狗被随机分配到 4 组,每组 10 只。所有狗都接受了使用 0.5% LBUP 的区域神经阻滞。第 1 组(LBUP + DEX IV)同时静脉注射 DEX;第 2 组(LBUP + PLC IV)同时静脉注射安慰剂;第 3 组(LBUP + DEX IO)同时在一次眶下 (IO) 阻滞中注射 DEX;第 4 组(LBUP + DEX IA)同时在一次下齿槽 (IA) 阻滞中注射 DEX。在进行口腔阻滞前和手术结束时测定血清皮质醇和血糖浓度。麻醉前和麻醉结束后 6 小时内每小时对镇静和行为评分进行评估。各组的皮质醇浓度在两个评估时间内均无变化。葡萄糖浓度较高(P
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来源期刊
Journal of Veterinary Dentistry
Journal of Veterinary Dentistry VETERINARY SCIENCES-
CiteScore
1.00
自引率
10.00%
发文量
59
期刊介绍: The Journal of Veterinary Dentistry (JOVD) is the official peer-reviewed publication of the Foundation for Veterinary Dentistry. The JOVD provides a continuing education forum for veterinary dental scientists, veterinarians, dentists, and veterinary/dental technicians and hygienists who are engaged in veterinary dental practice. JOVD articles provide practical and scientifically sound information covering not only the medical and surgical aspects, but also specific categories as they relate to clinical practice.
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