CFTR and colorectal cancer susceptibility: an urgent need for further studies.

IF 14.3 1区 医学 Q1 ONCOLOGY Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI:10.1016/j.trecan.2024.07.006
S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik
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引用次数: 0

Abstract

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

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CFTR 与结直肠癌易感性:迫切需要进一步研究。
囊性纤维化跨膜传导调节器(CFTR)基因突变会导致囊性纤维化,这是一种以上皮细胞液体分泌异常为特征的多器官疾病。最近的研究描述了 CFTR 功能失常与结肠直肠癌(CRC)易感性增高之间的联系。在此,我们概述了这些联系,并提出了进一步研究的方向。
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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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