The contribution of rural/urban residence to incidence and survival in thymoma and thymic carcinoma, a retrospective cohort study of the SEER 2000–2020 database

IF 2.4 3区医学 Q3 ONCOLOGY Cancer Epidemiology Pub Date : 2024-08-14 DOI:10.1016/j.canep.2024.102645

Joseph Cascone , Bianca Ituarte , Vani Patel , Annsophia Mompoint , Mitchell Taylor , Emmanuel Daon

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Abstract

Objective

Rural-urban healthcare disparities have been demonstrated throughout the United States, particularly in acquiring oncologic care. In this study, we aim to discern the role of rural-urban health disparities in thymic cancer incidence and uncover potential survival disparities.

Methods

The Surveillance, Epidemiology, and End Results (SEER) 17-State database was queried for all cases of thymoma (ICD-O-3/3 codes: 8580–8585) and thymic carcinoma (8586) located in the thymus (primary site code C37.9) diagnosed between 2000 and 2020. Residence was established using SEER Rural-Urban Continuum Codes. Incidence trend modeling for rural versus urban patients was completed using Joinpoint Regression Software. Chi-square, Kaplan-Meier with log-rank testing, and Cox proportional hazards was completed using SPSS, with significance set to p <0.05.

Results

Joinpoint analysis revealed a significant growth in incidence in the urban population compared to a stagnant incidence among the rural population. Disease specific survival was higher among urban patients on univariate modeling (p = 0.010), and confirmed on multivariate analysis, whereby rural living conferred an adjusted hazard ratio of 1.263 (95 % CI 1.045–1.527; p = 0.016) in comparison to urban patients.

Conclusions

These findings demonstrate differences between thymic cancer incidence and outcomes in patients living in urban versus rural environments and demonstrate an important disparity.

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农村/城市居住地对胸腺瘤和胸腺癌发病率和存活率的影响，一项 SEER 2000-2020 年数据库的回顾性队列研究。

目的：美国各地都存在城乡医疗差距，尤其是在获得肿瘤治疗方面。在这项研究中，我们旨在发现城乡医疗差距在胸腺癌发病率中的作用，并揭示潜在的生存差距：方法：我们在监测、流行病学和最终结果（SEER）17 州数据库中查询了 2000 年至 2020 年期间诊断出的所有胸腺瘤（ICD-O-3/3 编码：8580-8585）和胸腺癌（8586）病例（主要部位编码 C37.9）。居住地使用 SEER 农村-城市连续编码确定。使用Joinpoint回归软件完成了农村与城市患者的发病趋势建模。使用 SPSS 完成了 Chi-square、Kaplan-Meier（带对数秩检验）和 Cox 比例危险度检验，显著性设置为 p 结果：连接点分析表明，与农村人口的发病率停滞不前相比，城市人口的发病率有明显增长。在单变量模型中，城市患者的疾病特异性生存率更高（p = 0.010），多变量分析证实了这一点，与城市患者相比，农村患者的调整后危险比为 1.263（95 % CI 1.045-1.527; p = 0.016）：这些研究结果表明，生活在城市和农村环境中的胸腺癌患者在发病率和预后方面存在差异，并显示出重要的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.