Neoplastic and non-neoplastic diseases associated with feline leukaemia virus (FeLV) in cats in southern Brazil

IF 2 3区农林科学 Q4 IMMUNOLOGY Comparative Immunology Microbiology and Infectious Diseases Pub Date : 2024-08-13 DOI:10.1016/j.cimid.2024.102228

Gustavo Willian Pandolfo , Thierry Grima de Cristo , Jéssica Aline Withoeft , Jennyfer Júlia da Silva Sá , Maria Augusta Fornara , Aline Viebrantz , Mariana Casa , Claudia Salete Wisser , Renata Assis Casagrande

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Abstract

The objective of this study was to categorise diseases associated with FeLV infection in cats. A total of 154 cats were submitted to necropsy, histopathology exam and anti-FeLV immunohistochemistry (IHC), and 83 (50.9 %) were IHC FeLV-positive. The cats age means of 4.1 years, including 3.6 % kittens, 34.9 % junior, 37.4 % prime, 18.1 % mature, 2.4 % senior, 3.6 % unknown age. Neoplastic diseases were most prevalent with leukaemia and lymphoma being most predominant, followed by viral diseases, bacterial, trauma, degenerative, intoxications, parasitic, malformation and others. FeLV+ cats were 5.73 times more likely to be diagnosed with neoplasms than other diseases. The odds ratio (OR) of FeLV+ cats developing leukaemia (OR = 7.75) and lymphoma (OR = 6.75) was higher than other neoplasms. FeLV infection was more prevalent in the mixed breed, junior to prime, male, with neoplastic diseases, including leukaemia and lymphoma. Therefore, understanding the diseases associated with FeLV is of paramount importance in Brazil due to its high prevalence, and it may encourage the implementation of prophylactic measures to reduce its dissemination.

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巴西南部与猫白血病病毒（FeLV）有关的肿瘤性和非肿瘤性疾病

本研究旨在对猫感染 FeLV 相关疾病进行分类。共有 154 只猫接受了尸体解剖、组织病理学检查和抗 FeLV 免疫组化（IHC），其中 83 只（50.9%）IHC FeLV 阳性。猫的平均年龄为 4.1 岁，其中幼猫占 3.6%，小猫占 34.9%，壮猫占 37.4%，成年猫占 18.1%，老年猫占 2.4%，未知年龄猫占 3.6%。肿瘤性疾病最常见，以白血病和淋巴瘤为主，其次是病毒性疾病、细菌性疾病、外伤、退化性疾病、中毒、寄生虫病、畸形等。FeLV+猫患肿瘤的几率是其他疾病的 5.73 倍。FeLV+猫患白血病（OR = 7.75）和淋巴瘤（OR = 6.75）的几率比（OR）高于其他肿瘤。FeLV感染在混种、幼年至壮年、雄性、患有肿瘤性疾病（包括白血病和淋巴瘤）的猫中更为普遍。因此，由于 FeLV 的高流行率，了解与 FeLV 相关的疾病在巴西至关重要，这可能会鼓励实施预防措施以减少其传播。

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来源期刊

Comparative Immunology Microbiology and Infectious Diseases 医学-免疫学

CiteScore

4.60

自引率

0.00%

发文量

102

审稿时长

40 days

期刊介绍： Comparative Immunology, Microbiology & Infectious Diseases aims to respond to the concept of "One Medicine" and to provide a venue for scientific exchange. Based on the concept of "Comparative Medicine" interdisciplinary cooperation between specialists in human and animal medicine is of mutual interest and benefit. Therefore, there is need to combine the respective interest of physicians, veterinarians and other health professionals for comparative studies relevant to either human or animal medicine . The journal is open to subjects of common interest related to the immunology, immunopathology, microbiology, parasitology and epidemiology of human and animal infectious diseases, especially zoonotic infections, and animal models of human infectious diseases. The role of environmental factors in disease emergence is emphasized. CIMID is mainly focusing on applied veterinary and human medicine rather than on fundamental experimental research.