Toxic air pollution and cognitive decline: Untangling particulate matter

IF 3.8 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Health & Place Pub Date : 2024-08-16 DOI:10.1016/j.healthplace.2024.103330
Kerry Ard , Jason Thomas , Clair Bullock
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Abstract

There is increasing evidence indicating air pollution is an important factor influencing the aging brain. However, much of this work measures air pollution using particulate matter (PM). Yet we know that the chemical components of PM are not consistent across space or time. Rather, the possible chemical mixtures of PM vary and are therefore not reliably measuring the same thing across studies. In this study we attempt to disentangle the effects of the components of measured PM by using estimates of concurrent exposures of 415 industrial air toxics, as well as 44 neuro- and developmental toxics. Using bivariate latent curve models, we leverage individual level panel data from the bi-annual Health and Retirement Study to test how these exposures relate to cognitive score trajectories of respondents across the years 2002–2012. We find that more exposure to neurotoxics was associated with faster rate of cognitive decline by 1.09 points (p < 0.05).

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有毒空气污染与认知能力下降:解开微粒物质之谜
越来越多的证据表明,空气污染是影响大脑老化的一个重要因素。然而,这项工作大多使用颗粒物(PM)来测量空气污染。然而我们知道,可吸入颗粒物的化学成分在空间或时间上并不一致。相反,可吸入颗粒物中可能存在的化学混合物各不相同,因此在不同的研究中无法可靠地测量同一种物质。在本研究中,我们试图利用对同时暴露于 415 种工业空气有毒物质以及 44 种神经和发育有毒物质的估计值,来区分所测量的可吸入颗粒物成分的影响。通过使用二元潜曲线模型,我们利用一年两次的健康与退休研究(Health and Retirement Study)中的个人水平面板数据,检验了这些暴露与受访者在 2002-2012 年间的认知分数轨迹之间的关系。我们发现,接触神经毒素越多,认知能力下降的速度就越快,下降了 1.09 分(p < 0.05)。
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来源期刊
Health & Place
Health & Place PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
7.70
自引率
6.20%
发文量
176
审稿时长
29 days
期刊介绍: he journal is an interdisciplinary journal dedicated to the study of all aspects of health and health care in which place or location matters.
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