Autoantibody testing in myositis: an update.

IF 5.2 2区 医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2024-08-20 DOI:10.1097/BOR.0000000000001039
Fionnuala K McMorrow, Natalie Anwyll, Sarah L Tansley
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Abstract

Purpose of review: This review aims to provide an update on myositis autoantibody testing strategies. We have focussed on the reliability and usefulness of different myositis autoantibody detection methods, including commonly used solid phase immunoassays and newer discovery techniques.

Recent findings: Several studies have highlighted the limitations of currently available immunoassays, particularly when used in populations with low pretest probability and without supporting clinical evidence. While many autoantibodies, such as anti-Jo1, are detected with high sensitivity and specificity, the low incidence of myositis autoantibodies in tested populations reduces their positive predictive value. The low sensitivity of line immunoassays to detect key myositis autoantibodies, including anti-TIF1γ and rarer antisynthetase autoantibodies, is a concern.

Summary: Myositis autoantibodies are widely accepted as important clinical tools, and hence, there is a significant demand for reliable, accessible, and affordable detection methods. False positives and negative results have the potential to impact on patient care, particularly for malignancy and lung disease associated autoantibodies. Increased availability of myositis autoantibody testing has led to a rise in requests from a broader range of clinicians. It is critically important that clinicians are aware of specific limitations of tests and interpret results in the context of clinical findings.

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肌炎的自身抗体检测:最新进展。
综述目的:本综述旨在介绍肌炎自身抗体检测策略的最新进展。我们重点讨论了不同肌炎自身抗体检测方法的可靠性和实用性,包括常用的固相免疫分析法和较新的发现技术:一些研究强调了目前可用的免疫测定方法的局限性,尤其是在检测前概率较低和没有临床证据支持的人群中使用时。虽然许多自身抗体(如抗 Jo1)的检测灵敏度和特异性都很高,但肌炎自身抗体在检测人群中的低发生率降低了其阳性预测值。行免疫测定法检测主要肌炎自身抗体(包括抗TIF1γ和较罕见的抗异烟酸酶自身抗体)的灵敏度较低,令人担忧。假阳性和阴性结果有可能影响患者的治疗,尤其是与恶性肿瘤和肺部疾病相关的自身抗体。肌炎自身抗体检测的日益普及导致更多临床医生提出了检测要求。至关重要的是,临床医生应了解检测的具体局限性,并结合临床结果来解释检测结果。
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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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