Behavioral dysregulation in Nile tilapia (Oreochromis niloticus, GIFT) post-Streptococcus agalactia infection: Role of the microbiota-gut-brain axis

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-08-16 DOI:10.1016/j.cbpc.2024.110006
Mengmeng Yi , Zhigang Liu , Guiyun Huang , He Wang , Jianmeng Cao , Zhang Wang , Miao Wang , Xiaoli Ke
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Abstract

In the aquatic farming industry, understanding the factors affecting fish behavior is crucial, particularly in response to infections that compromise welfare and productivity. Swimming performance is a key life history trait critical to their ecology. This study explores the swimming behavior imbalance in Nile tilapia (Oreochromis niloticus, GIFT) post-infection with Streptococcus agalactiae (GBS), a common pathogen responsible for significant losses in aquaculture. We focused on how the microbiota-gut-brain axis influences the behavioral response of tilapia to GBS infection. Behavioral changes were quantified by measuring collision times and swimming speeds, which decreased significantly following infection. This behavioral downturn is mediated by alterations in the microbiota-gut-brain axis, evidenced by increased levels of monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) in the brain and intestinal tissues. The study utilized pharmacological agents, the 5-HT1A receptor agonist (8-OH-DPAT) and antagonist (WAY-100635), to investigate their efficacy in mitigating these behavioral and biochemical changes. Both agents partially restored normal behavior by adjusting neurotransmitter concentrations disrupted by GBS infection. Additionally, a notable increase in the relative abundance of Streptococcus within the gut microbiota of infected fish highlights the potential role of specific bacterial populations in influencing host behavior. This research provides novel insights into the complex interactions between pathogen-induced gut microbiota changes and Nile tilapia's behavioral outcomes, highlighting potential avenues for improving fish health management through microbiota-targeted interventions.

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尼罗罗非鱼(Oreochromis niloticus, GIFT)感染无乳链球菌后的行为失调:微生物群-肠-脑轴的作用。
在水产养殖业中,了解影响鱼类行为的因素至关重要,尤其是在应对影响鱼类福利和生产力的感染时。游泳性能是对其生态至关重要的关键生活史特征。本研究探讨了尼罗罗非鱼(Oreochromis niloticus,GIFT)感染猪链球菌(GBS)后的游泳行为失衡,猪链球菌是一种常见的病原体,在水产养殖中造成了重大损失。我们重点研究了微生物群-肠-脑轴如何影响罗非鱼对 GBS 感染的行为反应。通过测量罗非鱼的碰撞时间和游泳速度来量化其行为变化。这种行为衰退是由微生物群-肠-脑轴的改变介导的,大脑和肠道组织中单胺神经递质(5-羟色胺、去甲肾上腺素和多巴胺)水平的升高证明了这一点。该研究利用 5-HT1A 受体激动剂(8-OH-DPAT)和拮抗剂(WAY-100635)这两种药剂来研究它们在缓解这些行为和生化变化方面的功效。这两种药物通过调整因 GBS 感染而紊乱的神经递质浓度,部分恢复了正常行为。此外,受感染鱼类肠道微生物群中链球菌的相对丰度明显增加,这突出表明特定细菌群在影响宿主行为方面的潜在作用。这项研究为病原体诱导的肠道微生物群变化与尼罗罗非鱼行为结果之间复杂的相互作用提供了新的见解,突出了通过微生物群靶向干预改善鱼类健康管理的潜在途径。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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