Serum creatinine and serum cystatin C as an index of muscle mass in adults.

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE Current Opinion in Nephrology and Hypertension Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI:10.1097/MNH.0000000000001022

Celina Liu, Andrew S Levey, Shoshana H Ballew

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Abstract

Purpose of review: Serum creatinine reflects both muscle mass and kidney function. Serum cystatin C has recently been recommended as an additional marker for estimating kidney function, and use of both markers together may provide an index of muscle mass. This review aims to describe the biological basis for and recent research examining the relationship of these markers to muscle mass in a range of adult populations and settings.

Recent findings: This review identified 67 studies, 50 of which had direct measures of muscle mass, and almost all found relationships between serum creatinine and cystatin C and muscle mass and related outcomes. Most studies have been performed in older adults, but similar associations were found in general populations as well as in subgroups with cancer, chronic kidney disease (CKD), and other morbid conditions. Creatinine to cystatin C ratio was the measure examined the most often, but other measures showed similar associations across studies.

Summary: Measures of serum creatinine and cystatin C together can be an index of muscle mass. They are simple and reliable measures that can be used in clinical practice and research. Further study is needed to determine actionable threshold values for each measure and clinical utility of testing and intervention.

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血清肌酐和血清胱抑素 C 作为成人肌肉质量的指标。

审查目的：血清肌酐可反映肌肉质量和肾功能。血清胱抑素 C 最近被推荐为估测肾功能的额外指标，同时使用这两种指标可提供肌肉质量指标。本综述旨在描述在一系列成年人群和环境中这些指标与肌肉质量关系的生物学基础和最新研究：本综述确定了 67 项研究，其中 50 项研究对肌肉质量进行了直接测量，几乎所有研究都发现了血清肌酐和胱抑素 C 与肌肉质量及相关结果之间的关系。大多数研究都是针对老年人进行的，但在普通人群以及患有癌症、慢性肾病（CKD）和其他病症的亚群体中也发现了类似的关联。肌酐与胱抑素 C 的比值是最常研究的指标，但其他指标在不同研究中也显示出类似的关联性。这些指标简单可靠，可用于临床实践和研究。还需要进一步研究，以确定每种指标的可操作阈值以及检测和干预的临床效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.