Real-world treatment patterns, resource utilization and costs in biliary tract cancers in the USA.

IF 3 4区 医学 Q2 ONCOLOGY Future oncology Pub Date : 2024-08-19 DOI:10.1080/14796694.2024.2379237
Liya Wang, Mukul Singhal, Adriana Valderrama, Bal Nepal, Shital Kamble, Madhulika Eluri, Usha Malhotra, Abby Siegel, Michael Grabner, Shilpi Swami, Milind Javle
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Abstract

Aim: To evaluate real-world treatment patterns, survival and healthcare-resource utilization in US patients with advanced biliary tract cancers (BTC) receiving systemic therapy.Patients & methods: This study used claims data from the Healthcare Integrated Research Database (HIRD®) linked to clinical data from the Cancer Care Quality Program (January 1, 2015-September 30, 2020).Results: Of 413 patients, 84.5% received gemcitabine-based first-line (1L) treatment, 46% received second-line treatment, and 16.5% received third-line (3L) treatment. All-cause mortality was 53% and approximately 70% of patients had ≥1 inpatient visit. The total mean per-patient-per-month all-cause costs were $19,589 for 1L and $33,534 for 3L treatment.Conclusion: Results showed poor survival, significant resource use and high costs as treatment line progresses for patients with advanced BTC.

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美国胆道癌症的实际治疗模式、资源利用率和成本。
目的:评估接受系统治疗的美国晚期胆道癌(BTC)患者的实际治疗模式、生存率和医疗资源利用率:本研究使用了医疗保健综合研究数据库(HIRD®)的索赔数据和癌症护理质量计划(2015年1月1日至2020年9月30日)的临床数据:在413名患者中,84.5%接受了以吉西他滨为基础的一线(1L)治疗,46%接受了二线治疗,16.5%接受了三线(3L)治疗。全因死亡率为 53%,约 70% 的患者≥1 次住院治疗。每名患者每月全因费用的平均总额为:一线治疗 19,589 美元,三线治疗 33,534 美元:结果显示,随着治疗线的延长,晚期 BTC 患者的生存率低、资源使用量大、费用高。
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来源期刊
Future oncology
Future oncology ONCOLOGY-
CiteScore
5.40
自引率
3.00%
发文量
335
审稿时长
4-8 weeks
期刊介绍: Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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