The autophagy proteome in the brain.

IF 4.2 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Neurochemistry Pub Date : 2024-08-18 DOI:10.1111/jnc.16204
Vitor I Ito-Silva, Bradley J Smith, Daniel Martins-de-Souza
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Abstract

As one of the most important cellular housekeepers, autophagy directly affects cellular health, homeostasis, and function. Even though the mechanisms behind autophagy are well described, how molecular alterations and dysfunctions can lead to pathology in disease contexts still demands deeper investigation. Proteomics is a widely employed tool used to investigate molecular alterations associated with pathological states and has proven useful in identifying alterations in protein expression levels and post-translational modifications in autophagy. In this narrative review, we expand on the molecular mechanisms behind autophagy and its regulation, and further compile recent literature associating autophagy disturbances in context of brain disorders, utilizing discoveries from varying models and species from rodents and cellular models to human post-mortem brain samples. To outline, the canonical pathways of autophagy, the effects of post-translational modifications on regulating each step of autophagy, and the future directions of proteomics in autophagy will be discussed. We further aim to suggest how advancing proteomics can help further unveil molecular mechanisms with regard to neurological disorders.

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大脑中的自噬蛋白质组
作为最重要的细胞管家之一,自噬直接影响着细胞的健康、平衡和功能。尽管自噬背后的机制已被充分描述,但分子改变和功能障碍如何导致疾病的病理变化仍需要更深入的研究。蛋白质组学是一种广泛应用的工具,用于研究与病理状态相关的分子改变,并已证明有助于确定自噬过程中蛋白质表达水平和翻译后修饰的改变。在这篇叙述性综述中,我们阐述了自噬及其调控背后的分子机制,并利用从啮齿动物和细胞模型到人类死后脑样本等不同模型和物种中的发现,进一步汇编了与脑部疾病相关的自噬紊乱的最新文献。我们将概述自噬的典型途径、翻译后修饰对自噬各步骤的调控作用以及自噬蛋白质组学的未来发展方向。我们还将进一步探讨蛋白质组学的发展如何有助于进一步揭示神经系统疾病的分子机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neurochemistry
Journal of Neurochemistry 医学-神经科学
CiteScore
9.30
自引率
2.10%
发文量
181
审稿时长
2.2 months
期刊介绍: Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.
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