Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan

IF 2.6 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of the Formosan Medical Association Pub Date : 2025-02-01 DOI:10.1016/j.jfma.2024.07.024

Chi-Neu Tsai , Yu-Chung Chang , Hsun-Ching Chao , Yi-Hsiang Hsu , Yuan-Hung Wang , Shih-Yen Chen

{"title":"Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan","authors":"Chi-Neu Tsai , Yu-Chung Chang , Hsun-Ching Chao , Yi-Hsiang Hsu , Yuan-Hung Wang , Shih-Yen Chen","doi":"10.1016/j.jfma.2024.07.024","DOIUrl":null,"url":null,"abstract":"<div><div>Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their genomic analysis and clinical manifestations compared to GII.4 infections.</div><div>There were 30.5% (29 out of 95 cases) with NoV infection. The most common genotype was GII.4 (22, 75.9%) followed by GII.12 (5, 17.2%) and GII.3 (2, 6.9%). Phylogenetic analysis showed that our GII.12 sequences were closely aligned with reference genomes identified in the United Kingdom and the United States of America. When compared to patients infected by GII.4 NoV, those with GII.12 infection experienced a lower frequency and shorter duration of diarrhea. Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 2","pages":"Pages 186-189"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Formosan Medical Association","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0929664624003449","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. GII.4 have played a major role in NoV infections while other genotypes were reported in sporadic outbreaks. In this study, we reported novel variant NoV GII.12 outbreaks in 2010, Taiwan with their genomic analysis and clinical manifestations compared to GII.4 infections.

There were 30.5% (29 out of 95 cases) with NoV infection. The most common genotype was GII.4 (22, 75.9%) followed by GII.12 (5, 17.2%) and GII.3 (2, 6.9%). Phylogenetic analysis showed that our GII.12 sequences were closely aligned with reference genomes identified in the United Kingdom and the United States of America. When compared to patients infected by GII.4 NoV, those with GII.12 infection experienced a lower frequency and shorter duration of diarrhea. Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2010 年台湾北部新出现的诺如病毒 GII.12 感染。

诺如病毒（NoV）是后轮状病毒疫苗时代新出现的肠道感染病原体。GII.4型在NoV感染中扮演了主要角色，而其他基因型则在零星爆发中有所报道。在本研究中，我们报告了 2010 年在台湾爆发的新型变异 NoV GII.12 基因型，并将其基因组分析和临床表现与 GII.4 型感染进行了比较。30.5%的病例（95 例中有 29 例）感染了 NoV。最常见的基因型是 GII.4（22，75.9%），其次是 GII.12（5，17.2%）和 GII.3（2，6.9%）。系统发育分析表明，我们的 GII.12 序列与在英国和美国发现的参考基因组密切吻合。与感染 GII.4 NoV 的患者相比，感染 GII.12 的患者腹泻频率较低，持续时间较短。要揭示 NoV 基因型与临床结果之间错综复杂的关系，为公共卫生干预和治疗策略提供指导，就必须继续开展研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of the Formosan Medical Association 医学-医学：内科

CiteScore

6.50

自引率

6.20%

发文量

381

审稿时长

57 days

期刊介绍： Journal of the Formosan Medical Association (JFMA), published continuously since 1902, is an open access international general medical journal of the Formosan Medical Association based in Taipei, Taiwan. It is indexed in Current Contents/ Clinical Medicine, Medline, ciSearch, CAB Abstracts, Embase, SIIC Data Bases, Research Alert, BIOSIS, Biological Abstracts, Scopus and ScienceDirect. As a general medical journal, research related to clinical practice and research in all fields of medicine and related disciplines are considered for publication. Article types considered include perspectives, reviews, original papers, case reports, brief communications, correspondence and letters to the editor.