Hair cortisol concentrations are associated with greater adiposity in late adolescence amongst non-Hispanic White individuals

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-08-19 DOI:10.1111/ijpo.13164

Melissa N. Sidote, Nicole Bornkamp, Sheryl L. Rifas-Shiman, Marie-France Hivert, Emily Oken, Amy R. Nichols, Mingyu Zhang

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Abstract

Introduction

Hair cortisol concentration (HCC) is a biomarker of long-term stress. Higher HCC is associated with higher adiposity in adults; however, associations are not well characterized in adolescents.

Objective

To examine cross-sectional associations of HCC with adiposity in late adolescence.

Methods

Amongst 336 non-Hispanic White participants (48.5% female, mean 17.7 years) in Project Viva, we used multivariable linear regression models, overall and sex-stratified, to estimate associations of HCC with body mass index (BMI), bioelectric impedance (BIA) percent body fat, waist circumference (WC) and dual X-ray absorptiometry-measured percent and total fat or trunk fat mass. We adjusted models for age and known predictors of adiposity.

Results

Median (interquartile range) HCC was 2.1 pm/mg (1.0–4.5) and mean (SD) BMI was 23.1 kg/m² (3.9), BIA %body fat 20.2% (9.9) and WC 80.6 cm (10.9). In adjusted models, higher HCC (per doubling) was associated with higher BMI (β = 0.19 kg/m²; 95%CI 0.00, 0.37) and BIA percent body fat (β = 0.41%; 95%CI 0.04, 0.77). We observed no evidence of effect modification by sex.

Conclusions

Higher HCC was associated with greater adiposity in late adolescence. Further research is needed to disentangle the relationship between HCC and adolescent adiposity, including the temporal direction of the relationship and sex-specific associations.

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在非西班牙裔白人中，毛发皮质醇浓度与青春期后期的肥胖程度有关。

简介毛发皮质醇浓度（HCC）是长期压力的生物标志物。在成人中，较高的毛发皮质醇浓度与较高的脂肪率有关；但在青少年中，两者之间的关系并不十分明确：研究方法：在 336 名非西班牙裔青少年中，调查 HCC 与青少年后期肥胖的横断面关系：在 "万岁计划 "的 336 名非西班牙裔白人参与者（48.5% 为女性，平均年龄为 17.7 岁）中，我们使用多变量线性回归模型（整体和性别分层）来估计 HCC 与体重指数 (BMI)、生物电阻抗 (BIA) 体脂百分比、腰围 (WC) 和双 X 射线吸收测量法测量的脂肪百分比和总脂肪或躯干脂肪量之间的关系。我们根据年龄和已知的脂肪预测因素对模型进行了调整：HCC 中位数（四分位间范围）为 2.1 pm/mg (1.0-4.5)，BMI 平均值（标清）为 23.1 kg/m2 (3.9)，BIA 体脂百分比为 20.2% (9.9)，WC 为 80.6 cm (10.9)。在调整模型中，较高的 HCC（每加倍）与较高的 BMI（β = 0.19 kg/m2；95%CI 0.00，0.37）和 BIA 体脂百分比（β = 0.41%；95%CI 0.04，0.77）相关。我们没有观察到因性别而改变效应的证据：结论：较高的 HCC 与青春期后期较高的脂肪率有关。结论：HCC较高与青春期后期肥胖有关，需要进一步研究来厘清HCC与青春期肥胖之间的关系，包括这种关系的时间方向和性别特异性关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.