Deciphering the kidney hemodynamic effects of SGLT2 inhibition: translating insights from rats to humans in type 2 diabetes

IF 14.8 1区 医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2024-08-20 DOI:10.1016/j.kint.2024.06.018
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Abstract

The attenuation of glomerular hyperfiltration is posited to be a principal mechanism underlying the kidney protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in diabetic kidney disease. Notably, the impact of SGLT2 inhibitors on kidney hemodynamic function has been posited to vary between type 1 and type 2 diabetes. The study by Wada et al. documents that in an animal model of type 2 diabetes, SGLT2 inhibitors mitigate glomerular hyperfiltration predominantly through afferent arteriolar constriction, a process mediated by the adenosine/A1 receptor pathway. This observation is consistent with mechanisms identified in type 1 diabetes, arguing for similar methods in type 1 and 2 diabetes.

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解读 SGLT2 抑制剂对肾脏血液动力学的影响:将对 2 型糖尿病大鼠的研究成果转化为人类研究成果
钠-葡萄糖共转运体-2(SGLT2)抑制剂对糖尿病肾病的肾脏保护作用的主要机制是减轻肾小球高滤过。值得注意的是,SGLT2 抑制剂对肾脏血液动力学功能的影响被认为在 1 型和 2 型糖尿病之间存在差异。Wada 等人的研究表明,在 2 型糖尿病动物模型中,SGLT2 抑制剂主要通过传入动脉收缩缓解肾小球高滤过,这一过程由腺苷/A1 受体途径介导。这一观察结果与在 1 型糖尿病中发现的机制一致,证明 1 型和 2 型糖尿病中的方法相似。
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来源期刊
Kidney international
Kidney international 医学-泌尿学与肾脏学
CiteScore
23.30
自引率
3.10%
发文量
490
审稿时长
3-6 weeks
期刊介绍: Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.
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