{"title":"Synthesis of functionalized superparamagnetic iron oxide nanoparticles for ibuprofen and naproxen hydrophobic drugs delivery","authors":"","doi":"10.1016/j.matchemphys.2024.129775","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, we have developed a superparamagnetic iron oxide (IONPs) nanocarrier bi-functionalized using β-cyclodextrin (CD) and chitosan (CS) molecules. The synthesized semi-spherical CS-CD–SIO–NPs were mono-dispersed in size distribution with the average diameter of 80 nm. The loading of ibuprofen (IBU) and naproxen (NAP) on the surface of the CS-CD–SIO–NPs as hydrophobic drug models were evaluated as the function of temperature and pH values. Using the optimal conditions, the NAP-loaded CS-CD–SIO–NPs showed Korsmeyer- Peppas kinetics governed by diffusion and swelling of the drug molecule. On the other hand, IBU-loaded nanocarrier followed the zero-order kinetic model, where the release profile is independent of its concentration. Nitrogen adsorption-desorption isotherms revealed the mono-dispersed ink-bottle shapes of the pores (pore size ∼2–4 nm) on the surface of mesoporous CS-CD–SIO–NPs. The synthesized nanocarrier exhibited enhanced biocompatibility in the presence of 3T3 and HepG2 cell lines (90 % cell viability up to 150 μg/mL concentration. Overall, the developed β-CD and chitosan grafted-iron oxide nanocarrier showed enhanced drug release kinetics and biocompatibility, which can be ideal for drug delivery applications, especially for hydrophobic drugs.</p></div>","PeriodicalId":18227,"journal":{"name":"Materials Chemistry and Physics","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry and Physics","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0254058424009003","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, we have developed a superparamagnetic iron oxide (IONPs) nanocarrier bi-functionalized using β-cyclodextrin (CD) and chitosan (CS) molecules. The synthesized semi-spherical CS-CD–SIO–NPs were mono-dispersed in size distribution with the average diameter of 80 nm. The loading of ibuprofen (IBU) and naproxen (NAP) on the surface of the CS-CD–SIO–NPs as hydrophobic drug models were evaluated as the function of temperature and pH values. Using the optimal conditions, the NAP-loaded CS-CD–SIO–NPs showed Korsmeyer- Peppas kinetics governed by diffusion and swelling of the drug molecule. On the other hand, IBU-loaded nanocarrier followed the zero-order kinetic model, where the release profile is independent of its concentration. Nitrogen adsorption-desorption isotherms revealed the mono-dispersed ink-bottle shapes of the pores (pore size ∼2–4 nm) on the surface of mesoporous CS-CD–SIO–NPs. The synthesized nanocarrier exhibited enhanced biocompatibility in the presence of 3T3 and HepG2 cell lines (90 % cell viability up to 150 μg/mL concentration. Overall, the developed β-CD and chitosan grafted-iron oxide nanocarrier showed enhanced drug release kinetics and biocompatibility, which can be ideal for drug delivery applications, especially for hydrophobic drugs.
期刊介绍:
Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.