Literature-based Survey of Medicinal Plants Since 1900: A Case Study to Treat Cancer in the Sultanate of Oman.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL Current topics in medicinal chemistry Pub Date : 2024-08-21 DOI:10.2174/0115680266318053240819100111

Asif Khan, Ajmal Khan, Waheed Murad, Sobia Ahsan Halim, Hammad Ahmad Jan, Mohammed Al-Broumi, Ahmed Al-Harrasi

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Abstract

Ethnopharmacological relevance: Due to the high prevalence of cancer, researchers for the past decades have made considerable efforts for its management and treatment. Medicinal plants have always been exploited to discover novel anticancer agents. Oman's huge biodiversity has created a rich source of traditional medicine.

Objective: The current survey has aimed to document the traditionally used medicinal plants of Oman and their therapeutic role in the treatment of cancer.

Material method: This study comprises of literature-based survey through different databases, including Google, Scopus, Google Scholar, Web of Science, Science Direct, Springer Link, BioMed Central and PubMed.

Results: The current review revealed a total of 57 plant species that belong to 35 families that are used in the treatment of cancer in Oman. Most documented plants belong to Solanaceae (6 sp.), Apocyanaceae (5 sp.) and Lamiaceae (4 sp.). The literature reveals that the residents of the area mostly use leaves (38.5%) and prepare their recipes in the form of decoction (40.3%). Moreover, herbs are the most dominant life form (43.85%). Among all forms of cancer in Oman, breast (47%), wound (26), and lung cancer (0.5%) were found dominantly. A literature study confirmed that the medicinal plants used for cancer in Oman are rich in phytochemicals such as quercetin, allicin, coumarin, alliin, kaempferol, solamargine, rutin, lupeol, ursolic acid and luteolin that have shown significant biological activities including anti-cancer potential. It reflects the efficacy of these plants to be used as a medicine in clinical trials. Among all, Boswellia sacra Flueck. is of key importance due to the presence Boswellic acid being used for the treatment of different types of cancer.

Conclusion: The residents of Oman have great knowledge about the traditional use of medicinal plants for the treatment of various diseases like cancer. The therapeutic potential and physiological efficacy of Omani medicinal plants should be further explored at a molecular level via in vivo and in vitro experiments.

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对 1900 年以来药用植物的文献调查：阿曼苏丹国癌症治疗案例研究》。

民族药理学意义：由于癌症的高发病率，过去几十年来，研究人员为癌症的管理和治疗做出了巨大努力。人们一直在利用药用植物来发现新型抗癌剂。阿曼巨大的生物多样性为传统医药提供了丰富的资源：本次调查旨在记录阿曼的传统药用植物及其在治疗癌症方面的作用：本研究通过不同的数据库（包括 Google、Scopus、Google Scholar、Web of Science、Science Direct、Springer Link、BioMed Central 和 PubMed）进行文献调查：目前的研究显示，阿曼共有 35 个科的 57 种植物被用于治疗癌症。大多数记录在案的植物属于茄科（6 种）、花青素科（5 种）和苎麻科（4 种）。文献显示，该地区的居民大多使用叶子（38.5%），并以煎煮（40.3%）的形式制作食谱。此外，草药是最主要的生命形式（43.85%）。在阿曼的各种癌症中，主要是乳腺癌（47%）、伤口癌（26%）和肺癌（0.5%）。一项文献研究证实，阿曼用于治疗癌症的药用植物含有丰富的植物化学物质，如槲皮素、大蒜素、香豆素、大蒜素、山柰酚、索拉马金碱、芦丁、羽扇豆醇、熊果酸和木犀草素，这些物质具有显著的生物活性，包括抗癌潜力。这反映了这些植物在临床试验中作为药物使用的功效。其中，Boswellia sacra Flueck.由于含有乳香酸而被用于治疗不同类型的癌症，因此具有重要意义：阿曼居民对传统上使用药用植物治疗癌症等各种疾病非常了解。阿曼药用植物的治疗潜力和生理功效应通过体内和体外实验在分子水平上进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.