Solitary Functioning Kidneys Attenuate Renal Hemodynamics Responses to Angiotensin II in Male But Not in Female Rats.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Preventive Medicine Pub Date : 2024-07-17 eCollection Date: 2024-01-01 DOI:10.4103/ijpvm.ijpvm_195_23

Zahra Pezeshki, Mehdi Nematbakhsh

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Abstract

Backgrounds: People with solitary functioning kidneys (SFK) are prone to renal failure with time. Accordingly, local renin angiotensin system (RAS) and renal functions in subjects with SFK may act differently compared to normal condition. This study was designed to determine the renal hemodynamics responses to angiotensin II (Ang. II) in SFK male and female rats.

Methods: Fifty to sixty-day-old male and female Wistar rats were subjected to unilateral renal artery obstruction, and 28 days later basal renal hemodynamic responses to Ang. II were examined in SFK groups compared to sham groups.

Results: The findings indicated lower renal vascular resistance (RVR) and renal blood flow (RBF) responses to Ang. II in male SFK compared to sham group. Such observation was not seen in female animals.

Conclusions: An increase in renal metabolism due to hyperfunction, especially in SFK male rats, may cause a decrease in RVR. Moreover, the lower RBF response to Ang. II may be related to alteration to Ang. II receptors in the remnant kidneys in SFK rats.

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孤肾功能可减轻雄性大鼠肾血流动力学对血管紧张素 II 的反应，但对雌性大鼠却无影响

背景：单功能肾（SFK）患者随着时间的推移容易出现肾功能衰竭。因此，SFK 患者的局部肾素血管紧张素系统（RAS）和肾功能可能与正常人不同。本研究旨在确定 SFK 雄性和雌性大鼠的肾血流动力学对血管紧张素 II（Ang：方法：对 50-60 天大的雌雄 Wistar 大鼠进行单侧肾动脉阻塞，28 天后检查 SFK 组和 SFK 组大鼠对 Ang.结果表明，SFK 组大鼠的肾血管通透性低于假肾组：结果：研究结果表明，与假肾组相比，雄性 SFK 的肾血管阻力（RVR）和肾血流量（RBF）对 Ang.结果：研究结果表明，与假肾组相比，雄性 SFK 对 Ang.II 的肾血管阻力（RVR）和肾血流量（RBF）反应较低。雌性动物中未见此类观察结果：结论：功能亢进导致的肾脏代谢增加，尤其是在雄性 SFK 大鼠中，可能会导致 RVR 下降。此外，RBF 对 Ang.此外，RBF 对 Ang.II受体的改变有关。

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来源期刊

International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

4.80%

发文量

107

期刊介绍： International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.