{"title":"[Dynamics of mandibular density during therapy with zolendronic acid].","authors":"N S Nurieva, I G Shelegova, V A Fanakin","doi":"10.17116/stomat202410304133","DOIUrl":null,"url":null,"abstract":"<p><strong>The aim of the study: </strong>Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.</p><p><strong>Materials and methods: </strong>The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.</p><p><strong>Results: </strong>Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X<sub>1</sub>» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X<sub>1</sub> + 49 HU.</p><p><strong>Conclusion: </strong>The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 4","pages":"33-36"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stomatologiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/stomat202410304133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of the study: Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.
Materials and methods: The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.
Results: Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X1» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X1 + 49 HU.
Conclusion: The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.
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