Molecular understanding and clinical aspects of tumor-associated macrophages in the immunotherapy of renal cell carcinoma.

IF 11.4 1区 医学 Q1 ONCOLOGY Journal of Experimental & Clinical Cancer Research Pub Date : 2024-08-22 DOI:10.1186/s13046-024-03164-y
Han Liu, Zongwei Lv, Gong Zhang, Zhenhong Yan, Song Bai, Dan Dong, Kefeng Wang
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Abstract

Renal cell carcinoma (RCC) is one of the most common tumors that afflicts the urinary system, accounting for 90-95% of kidney cancer cases. Although its incidence has increased over the past decades, its pathogenesis is still unclear. Tumor-associated macrophages (TAMs) are the most prominent immune cells in the tumor microenvironment (TME), comprising more than 50% of the tumor volume. By interacting with cancer cells, TAMs can be polarized into two distinct phenotypes, M1-type and M2-type TAMs. In the TME, M2-type TAMs, which are known to promote tumorigenesis, are more abundant than M1-type TAMs, which are known to suppress tumor growth. This ratio of M1 to M2 TAMs can create an immunosuppressive environment that contributes to tumor cell progression and survival. This review focused on the role of TAMs in RCC, including their polarization, impacts on tumor proliferation, angiogenesis, invasion, migration, drug resistance, and immunosuppression. In addition, we discussed the potential of targeting TAMs for clinical therapy in RCC. A deeper understanding of the molecular biology of TAMs is essential for exploring innovative therapeutic strategies for the treatment of RCC.

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肿瘤相关巨噬细胞在肾细胞癌免疫疗法中的分子认识和临床应用。
肾细胞癌(RCC)是泌尿系统最常见的肿瘤之一,占肾癌病例的 90-95%。尽管过去几十年来其发病率有所上升,但其发病机制仍不清楚。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)中最主要的免疫细胞,占肿瘤体积的 50%以上。通过与癌细胞相互作用,TAMs 可极化为两种不同的表型,即 M1 型和 M2 型 TAMs。在TME中,已知促进肿瘤发生的M2型TAMs比已知抑制肿瘤生长的M1型TAMs更多。M1 型 TAM 与 M2 型 TAM 的这种比例可创造一种免疫抑制环境,从而促进肿瘤细胞的进展和存活。本综述重点探讨了 TAMs 在 RCC 中的作用,包括其极化、对肿瘤增殖、血管生成、侵袭、迁移、耐药性和免疫抑制的影响。此外,我们还讨论了靶向 TAMs 在 RCC 临床治疗中的潜力。加深对TAMs分子生物学的了解对于探索治疗RCC的创新疗法至关重要。
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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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