Pub Date : 2026-03-26DOI: 10.1186/s13046-026-03685-8
Mehrdad Zarei, Semmer A Ali, Alexander W Loftus, Faith Nakazzi, Hallie J Graor, Om Prajapati, Sami O Abul-Khoudoud, John M Asara, Rui Wang, Jordan M Winter, Luke D Rothermel
{"title":"Melanoma resists chemotherapy through an adaptive mitochondrial response.","authors":"Mehrdad Zarei, Semmer A Ali, Alexander W Loftus, Faith Nakazzi, Hallie J Graor, Om Prajapati, Sami O Abul-Khoudoud, John M Asara, Rui Wang, Jordan M Winter, Luke D Rothermel","doi":"10.1186/s13046-026-03685-8","DOIUrl":"https://doi.org/10.1186/s13046-026-03685-8","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1186/s13046-026-03699-2
Anna Kotarac, Hiroki Osumi, Alexander Malt, Keziban Merve Alp, Armin Jarosch, Johannes Werner, Manuela Benary, Christopher C M Neumann, Ryoji Yao, Philipp Mertins, Roland Eils, Dieter Beule, Christine Sers, Ulrich Keilholz, Naveed Ishaque, Sebastian Stintzing, Loredana Vecchione
{"title":"BRAF<sup>V600E</sup> patient derived colon cancer organoids identify biomarkers of response to EGFR and BRAF inhibition and replicate clinical data.","authors":"Anna Kotarac, Hiroki Osumi, Alexander Malt, Keziban Merve Alp, Armin Jarosch, Johannes Werner, Manuela Benary, Christopher C M Neumann, Ryoji Yao, Philipp Mertins, Roland Eils, Dieter Beule, Christine Sers, Ulrich Keilholz, Naveed Ishaque, Sebastian Stintzing, Loredana Vecchione","doi":"10.1186/s13046-026-03699-2","DOIUrl":"https://doi.org/10.1186/s13046-026-03699-2","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1186/s13046-026-03696-5
Hongze Chen, Le Li, Jisheng Hu, Zhongjie Zhao, Liang Ji, Chundong Cheng, Guangquan Zhang, Tao Zhang, Yilong Li, Hua Chen, Shangha Pan, Bei Sun
{"title":"Correction: UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.","authors":"Hongze Chen, Le Li, Jisheng Hu, Zhongjie Zhao, Liang Ji, Chundong Cheng, Guangquan Zhang, Tao Zhang, Yilong Li, Hua Chen, Shangha Pan, Bei Sun","doi":"10.1186/s13046-026-03696-5","DOIUrl":"https://doi.org/10.1186/s13046-026-03696-5","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":"45 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1186/s13046-026-03695-6
Quang Hieu Duong, Thi Khanh Le, Thi Thom Tran, Stéphane Audebert, Luc Camoin, Ngan Giang Nguyen, Michael Baboudjian, Sophie Giusiano, Uyen Thi Tu Phan, Souhaila Zaghdoudi, José Adelaide, Virginie Baylot, Martin Gleave, Carmen Garrido, David Taïeb, Palma Rocchi
{"title":"HSP27 functional switch drives castration-resistant prostate cancer via mTOR pathway activation, highlighting promising combination therapies.","authors":"Quang Hieu Duong, Thi Khanh Le, Thi Thom Tran, Stéphane Audebert, Luc Camoin, Ngan Giang Nguyen, Michael Baboudjian, Sophie Giusiano, Uyen Thi Tu Phan, Souhaila Zaghdoudi, José Adelaide, Virginie Baylot, Martin Gleave, Carmen Garrido, David Taïeb, Palma Rocchi","doi":"10.1186/s13046-026-03695-6","DOIUrl":"https://doi.org/10.1186/s13046-026-03695-6","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-21DOI: 10.1186/s13046-026-03698-3
Gloria Ravegnini, Daniele Esposito, Francesca Gorini, Tainah Dorina Marforio, Emma Coschina, Eva Benuzzi, Antonella Simone, Ahmed Samaha, Aldo Di Vito, Martina Rossi, Patrizia Hrelia, Alessandra Locatelli, Matteo Calvaresi, Nicola Facchinello, Rita Morigi, Sabrina Angelini
{"title":"Identification of MBT3T as a new effective therapeutic option in imatinib-resistant gastrointestinal stromal tumors (GISTs).","authors":"Gloria Ravegnini, Daniele Esposito, Francesca Gorini, Tainah Dorina Marforio, Emma Coschina, Eva Benuzzi, Antonella Simone, Ahmed Samaha, Aldo Di Vito, Martina Rossi, Patrizia Hrelia, Alessandra Locatelli, Matteo Calvaresi, Nicola Facchinello, Rita Morigi, Sabrina Angelini","doi":"10.1186/s13046-026-03698-3","DOIUrl":"https://doi.org/10.1186/s13046-026-03698-3","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Immunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunotherapy response, accumulating evidence highlights tumor-associated macrophages (TAMs) as both preventors or mediators of cancer, and its related therapies. TAMs contribute to resistance through multiple mechanisms, such as promoting T-cell exclusion, suppressing antitumor immunity via immunoregulatory cytokines, engaging metabolic checkpoints, and facilitating tumor angiogenesis. Clinical and single-cell transcriptomic studies further underscore the association between high TAM infiltration and poor immunotherapy outcomes. Emerging therapeutic strategies aim to reprogram, deplete, or block recruitment of TAMs, with several approaches currently being evaluated in early-phase clinical trials. This review summarizes the double-edged sword of TAMs M1-like proinflammatory or M2-like immunosuppressive states, in causing or preventing cancer. A deeper understanding of TAM heterogeneity and dynamics may enable the rational design of combination therapies and the development of predictive biomarkers to guide personalized immunotherapy.
{"title":"The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy.","authors":"Raheleh Roudi, Behnaz Beikzadeh, Babak Beikzadeh, Sima Kalantari, Navid Sobhani","doi":"10.1186/s13046-026-03676-9","DOIUrl":"https://doi.org/10.1186/s13046-026-03676-9","url":null,"abstract":"<p><p>Immunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunotherapy response, accumulating evidence highlights tumor-associated macrophages (TAMs) as both preventors or mediators of cancer, and its related therapies. TAMs contribute to resistance through multiple mechanisms, such as promoting T-cell exclusion, suppressing antitumor immunity via immunoregulatory cytokines, engaging metabolic checkpoints, and facilitating tumor angiogenesis. Clinical and single-cell transcriptomic studies further underscore the association between high TAM infiltration and poor immunotherapy outcomes. Emerging therapeutic strategies aim to reprogram, deplete, or block recruitment of TAMs, with several approaches currently being evaluated in early-phase clinical trials. This review summarizes the double-edged sword of TAMs M1-like proinflammatory or M2-like immunosuppressive states, in causing or preventing cancer. A deeper understanding of TAM heterogeneity and dynamics may enable the rational design of combination therapies and the development of predictive biomarkers to guide personalized immunotherapy.</p>","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s13046-026-03690-x
Yongheng Zhao, Tingyue Gong, Hao Li, Haiping Lin, Minhao Yu, Yang Luo, Ming Zhong, Jun Qin
{"title":"METTL16-mediated m<sup>6</sup>A modification of MSMO1 modulates cholesterol metabolism and activates MAPK-p38/NF-κB signaling in colorectal cancer.","authors":"Yongheng Zhao, Tingyue Gong, Hao Li, Haiping Lin, Minhao Yu, Yang Luo, Ming Zhong, Jun Qin","doi":"10.1186/s13046-026-03690-x","DOIUrl":"https://doi.org/10.1186/s13046-026-03690-x","url":null,"abstract":"","PeriodicalId":50199,"journal":{"name":"Journal of Experimental & Clinical Cancer Research","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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