In vitro evaluation of the biocompatibility and bioactivity of a SLM-fabricated NiTi alloy with superior tensile property

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-08-23 DOI:10.1007/s10856-024-06822-x
Yu Sun, Zhihui Zhang, Qingping Liu, Luquan Ren, Jincheng Wang
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Abstract

Because nickel-titanium (NiTi) alloys have unique functions, such as superelasticity, shape memory, and hysteresis similar to bone in the loading-unloading cycles of their recoverable deformations. They likely offer good bone integration, a low loosening rate, individual customization, and ease of insertion. Due to the poor processability of NITI, traditional methods cannot manufacture NiTi products with complex shapes. Orthopedic NiTi implants need to show an adequate fracture elongation of at least 8%. Additive manufacturing can be used to prepare NiTi implants with complex structures and tunable porosity. However, as previously reported, additively manufactured NiTi alloys could only exhibit a maximum tensile fracture strain of 7%. In new reports, a selective laser melting (SLM)–NiTi alloy has shown greater tensile strain (15.6%). Nevertheless, due to the unique microstructure of additive manufacturing NiTi that differs from traditional NITI, the biocompatibility of SLM-NITI manufactured by this new process requires further evaluation In this study, the effects of the improved NiTi alloy on bone marrow mesenchymal stem cell (BMSC) proliferation, adhesion, and cell viability were investigated via in vitro studies. A commercial Ti-6Al-4V alloy was studied side-by-side for comparison. Like the Ti-6Al-4V alloy, the SLM-NiTi alloy exhibited low cytotoxicity toward BMSCs and similar effect on cell adhesion or cell viability. This study demonstrates that the new SLM-NiTi alloy, which has exhibited improved mechanical properties, also displays excellent biocompatibility. Therefore, this alloy may be a superior implant material in biomedical implantation.

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对具有优异拉伸性能的 SLM 制造镍钛合金的生物相容性和生物活性进行体外评估。
由于镍钛(NiTi)合金具有独特的功能,如超弹性、形状记忆以及在其可恢复变形的加载-卸载循环中与骨骼相似的滞后性。它们可能具有良好的骨整合性、低松动率、个性化定制和易于插入等特点。由于镍钛材料的加工性较差,传统方法无法制造形状复杂的镍钛产品。骨科镍钛植入物需要有足够的断裂伸长率,至少为 8%。增材制造可用于制备具有复杂结构和可调孔隙率的镍钛植入体。然而,根据之前的报道,添加剂制造的镍钛合金只能表现出 7% 的最大拉伸断裂应变。在新的报道中,一种选择性激光熔化(SLM)-镍钛合金显示出更大的拉伸应变(15.6%)。本研究通过体外研究调查了改进型镍钛合金对骨髓间充质干细胞(BMSC)增殖、粘附和细胞活力的影响。同时还对商用 Ti-6Al-4V 合金进行了对比研究。与 Ti-6Al-4V 合金一样,SLM-NiTi 合金对 BMSCs 的细胞毒性较低,对细胞粘附性或细胞活力的影响相似。这项研究表明,新型 SLM-NiTi 合金不仅具有更好的机械性能,还具有出色的生物相容性。因此,这种合金可能是生物医学植入中的一种优质植入材料。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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