Nationwide prevalence of type 2 diabetes mellitus and pre-diabetes in Pakistan: A systematic review and meta-analysis

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2024-08-22 DOI:10.1016/j.diabres.2024.111815

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Abstract

Type 2 diabetes mellitus (T2DM) and pre-diabetes (pre-DM) are significant health concerns in Pakistan. This systematic review and meta-analysis estimate the prevalence of T2DM and pre-DM, assessing regional, gender, and urban–rural differences. We searched PubMed, Scopus, Cochrane, and PakMediNet databases, identifying 3478 articles. After screening, 17 studies from 1995 to 2018 were included. The pooled prevalence of T2DM and pre-DM in Pakistan was found to be 10.0 % and 11.0 %, respectively. This equates to approximately 24 million individuals with T2DM and 26 million with pre-DM, totaling 50 million affected. Rural areas showed higher T2DM prevalence post-2000, with an odds ratio (OR) of 1.25 (95 % CI: 0.73 to 2.14). Gender analysis revealed a slightly higher, though statistically insignificant, prevalence of T2DM in females and a significantly higher prevalence of pre-DM in males (OR: 0.79, 95 % CI: 0.63 to 0.98). Regionally, Punjab had the highest T2DM prevalence (16 %), followed by Baluchistan (15 %), Sindh (14 %), and Khyber Pakhtunkhwa (KPK) (11 %). There is a substantial burden of T2DM and pre-DM in Pakistan, with significant regional and gender differences. Targeted interventions and resource allocation are needed to address the rising prevalence of diabetes, focusing on early detection and lifestyle modifications.

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巴基斯坦全国 2 型糖尿病和糖尿病前期的患病率：系统回顾和荟萃分析。

2 型糖尿病（T2DM）和糖尿病前期（Pre-DM）是巴基斯坦的重大健康问题。本系统综述和荟萃分析估计了 T2DM 和糖尿病前期的发病率，评估了地区、性别和城乡差异。我们检索了 PubMed、Scopus、Cochrane 和 PakMediNet 数据库，共发现 3478 篇文章。经过筛选，纳入了 1995 年至 2018 年的 17 项研究。研究发现，巴基斯坦 T2DM 和 DM 前期的总患病率分别为 10.0% 和 11.0%。这相当于约有 2400 万 T2DM 患者和 2600 万 DM 前期患者，总计 5000 万患者。2000 年后，农村地区的 T2DM 患病率较高，几率比 (OR) 为 1.25（95 % CI：0.73 至 2.14）。性别分析显示，女性的 T2DM 患病率略高，但在统计上并不显著，而男性的糖尿病前期患病率则明显较高（OR：0.79，95 % CI：0.63 至 0.98）。从地区来看，旁遮普省的 T2DM 患病率最高（16%），其次是俾路支省（15%）、信德省（14%）和开伯尔-普赫图赫瓦省（11%）。在巴基斯坦，T2DM 和 DM 前期患者人数众多，地区和性别差异显著。需要采取有针对性的干预措施并分配资源，以解决糖尿病患病率不断上升的问题，重点是早期发现和改变生活方式。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.