New guidelines reduce the risk of hospitalization for adult patients with uncomplicated Plasmodium falciparum malaria: An observational, multicenter, retrospective French study

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES Infectious diseases now Pub Date : 2024-08-20 DOI:10.1016/j.idnow.2024.104963

Sally Oceane Minka , Gilles Cottrell , Michel Cot , Fadi Hillary Minka , Marc Thellier , Christophe Choquet , Sandrine Houze

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Abstract

Objectives

We aimed to evaluate the impact of malaria declaration year (before or after 2017) on the frequency of hospitalization in metropolitan France of patients with uncomplicated non-vomiting P. falciparum malaria.

Patients and methods

An observational, multicenter, retrospective study was carried out, using the database from the French National Reference Centre for Malaria. Descriptive analysis and multivariate analysis by logistic regression were performed using the multiple imputation by chained equation method to handle missing data.

Results

More than 2000 (2184) uncomplicated non-vomiting P. falciparum malaria cases were recorded. Our multivariate analysis showed an association between the year 2018 and reduced risk of hospitalization (OR: 0.89; 95% CI: 0.81–0.97).

Conclusion

Compared to 2016, during 2018 we observed a trend toward ambulatory care for patients presenting with uncomplicated non-vomiting P. falciparum malaria.

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新指南降低了无并发症恶性疟原虫疟疾成年患者的住院风险：法国一项多中心回顾性观察研究。

目的：我们旨在评估疟疾申报年（2017 年之前或之后）对法国本土无并发症非呕吐恶性疟原虫疟疾患者住院频率的影响：我们旨在评估疟疾申报年份（2017年之前或之后）对法国大都市无并发症非呕吐恶性疟原虫疟疾患者住院频率的影响：利用法国国家疟疾参考资料中心的数据库开展了一项多中心回顾性观察研究。采用链式方程多重估算法处理缺失数据，通过逻辑回归进行描述性分析和多变量分析：结果：共记录了 2000 多例（2184 例）无并发症非呕吐恶性疟原虫疟疾病例。我们的多变量分析表明，2018年与住院风险降低之间存在关联（OR：0.89；95% CI：0.81-0.97）：与2016年相比，我们观察到2018年期间，无并发症非呕吐恶性疟原虫疟疾患者有接受非住院治疗的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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