Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2024-08-22 DOI:10.1016/j.preteyeres.2024.101290
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Abstract

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Current diagnostic modalities of AD generally focus on detecting the presence of amyloid β and tau protein in the brain (for example, positron emission tomography [PET] and cerebrospinal fluid testing), but these are limited by their high cost, invasiveness, and lack of expertise. Retinal imaging exhibits potential in AD screening and risk stratification, as the retina provides a platform for the optical visualization of the central nervous system in vivo, with vascular and neuronal changes that mirror brain pathology.

Given the paradigm shift brought by advances in artificial intelligence and the emergence of disease-modifying therapies, this article aims to summarize and review the current literature to highlight 8 trends in an evolving landscape regarding the role and potential value of retinal imaging in AD screening.

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视网膜成像在阿尔茨海默病筛查中的价值主张:八大演变趋势回顾
阿尔茨海默病(AD)是全球痴呆症的主要病因。目前的阿尔茨海默病诊断方法一般侧重于检测大脑中是否存在淀粉样β和tau蛋白(例如正电子发射断层扫描和脑脊液检测),但这些方法因成本高、侵入性大和缺乏专业知识而受到限制。视网膜成像为体内中枢神经系统的光学可视化提供了一个平台,其血管和神经元的变化反映了大脑的病理变化,因此在注意力缺失症筛查和风险分层方面具有潜力。鉴于人工智能的进步和疾病修饰疗法的出现带来的范式转变,本文旨在总结和回顾当前的文献,突出视网膜成像在AD筛查中的作用和潜在价值方面不断发展的8大趋势。
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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
期刊最新文献
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