Sleep-aiding music therapy for insomnia: Exploring EEG functional connectivity of sleep-related attentional bias

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY Sleep medicine Pub Date : 2024-08-14 DOI:10.1016/j.sleep.2024.08.015

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Abstract

Study objectives

This study aimed to investigate the relationship between sleep-aiding music and sleep-related attentional bias based on electroencephalography (EEG) functional connectivity (FC) in patients with insomnia disorder (ID), to evaluate the effectiveness of music in aiding sleep.

Method

This study included 30 participants, comprising 15 patients with ID and 15 healthy controls (HCs). Six types of music were selected for sleep aid, and a dot-probe task based on sleep-related attentional bias was utilized to collect behavioral and EEG data. Vigilance bias and disengagement bias were measured using reaction time and EEG FC. Differences in sleep-related attentional bias before and after the intervention of music were explored to evaluate the sleep-aiding effects and identify EEG biomarkers.

Results

Compared with HCs, patients with ID showed decreased sleep-related attentional bias of EEG FC between occipital-central and temporal-frontal lobes. Among the six types of music, International Standard Sleep Aid and Lullaby had a greater impact on decreasing vigilance bias in the ID group. Additionally, the International Standard Sleep Aid and Nature Sound were more effective in decreasing disengagement bias in the ID group. This study also examined the resting-state EEG FC of patients with ID before and after the intervention of music. The results showed that the FC in the temporal, frontal, and occipital lobes significantly differed before and after the intervention of music, especially with the use of International Standard Sleep Aid, Lullaby, and Alpha Sound Wave. However, it is worth noting that these three types of music showed no similarities in EEG FC, in contrast to the result of sleep-related attentional bias of EEG FC.

Conclusion

This study found that the sleep-related attentional bias of EEG FC has more distinct characteristics when compared to resting-state EEG FC. The results suggest that the sleep-related attentional bias of EEG FC could be a potential biomarker for assessing the sleep-aiding effect of music interventions. International Standard Sleep Aid was the most effective for patients with ID among six types of sleep-aiding music. These findings could facilitate the development of personalized therapies for patients with ID.

Clinical trials registration

Chinese Clinical Trial Register, http://www.chictr.org.cn, ID: ChiCTR2400081608.

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失眠症的助眠音乐疗法：探索与睡眠相关的注意力偏差的脑电图功能连接。

研究目的本研究旨在根据脑电图（EEG）功能连接（FC）研究失眠症（ID）患者的助眠音乐与睡眠相关注意偏差之间的关系，以评估音乐助眠的效果：这项研究包括 30 名参与者，其中包括 15 名失眠症患者和 15 名健康对照组（HCs）。研究选择了六种助眠音乐，并利用基于睡眠相关注意偏差的点探测任务收集行为和脑电图数据。通过反应时间和脑电图FC测量警觉偏差和脱离偏差。探讨了音乐干预前后睡眠相关注意偏差的差异，以评估助眠效果并确定脑电图生物标志物：结果：与普通人相比，ID患者枕叶-中央叶和颞叶-额叶之间的脑电图FC与睡眠相关的注意偏差有所下降。在六种类型的音乐中，国际标准助眠曲和摇篮曲对减少ID组患者的警觉偏差影响更大。此外，国际标准助眠音乐和大自然之音对减少智障组的脱离偏差更有效。这项研究还检查了音乐干预前后智障患者的静息态脑电图功能。结果显示，在音乐干预前后，颞叶、额叶和枕叶的 FC 有明显差异，尤其是在使用国际标准助眠曲、摇篮曲和阿尔法声波时。但值得注意的是，这三种类型的音乐在脑电功能上并无相似之处，这与脑电功能的睡眠相关注意偏差结果形成了鲜明对比：本研究发现，与静息状态脑电功能相比，与睡眠相关的脑电功能注意偏差具有更明显的特征。结果表明，脑电图功能与睡眠相关的注意偏差可能是评估音乐干预对睡眠帮助效果的潜在生物标志物。在六种助眠音乐中，国际标准助眠音乐对智障患者最有效。这些发现有助于开发针对ID患者的个性化疗法：中国临床试验注册中心，http://www.chictr.org.cn，ID：ChiCTR2400081608。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.