Sleep medicine最新文献

{"title":"Does therapeutic CPAP pressure correlate with OSA severity in children?","authors":"Sonia Khirani ,&nbsp;Lucie Griffon ,&nbsp;Marine Dosso ,&nbsp;Domenico Paolo La Regina ,&nbsp;Meryl Vedrenne-Cloquet ,&nbsp;Clément Poirault ,&nbsp;Brigitte Fauroux","doi":"10.1016/j.sleep.2025.02.033","DOIUrl":"10.1016/j.sleep.2025.02.033","url":null,"abstract":"<div><h3>Objective/background</h3><div>Continuous positive airway pressure (CPAP) is widely used to treat severe obstructive sleep apnea (OSA) in children. We observed that non polysomnography (PSG)-titrated CPAP pressures ranged close to 8 cmH₂O in children with OSA. The aim of this study was to determine if there was a relationship between OSA severity, the age of the children and CPAP pressure.</div></div><div><h3>Methods</h3><div>Children with OSA, comprising mainly children with complex OSA, who were started on constant CPAP, with no attended PSG according to our clinical practice, were included. CPAP pressure, baseline polygraphic and anthropometrics data were retrospectively collected.</div></div><div><h3>Results</h3><div>Mean therapeutic CPAP pressure was 8 ± 1 (range 6–12) cmH₂O in 153 children treated with CPAP at a mean age of 3.7 ± 3.4 (0.1–15.9) years. CPAP pressure slightly correlated with age at CPAP initiation (r = 0.226, p = 0.005), baseline mixed and obstructive apnea-hypopnea index (MOAHI; r = 0.185, p = 0.025), oxygen desaturation index (ODI; r = 0.300, p &lt; 0.001), mean (r = −0.230, p = 0.005) and minimal pulse oximetry (SpO₂; r = −0.318, p &lt; 0.001). BMI z-score did not correlate with CPAP pressure, apnea-hypopnea index (AHI), MOAHI, nor ODI. CPAP pressure, AHI, MOAHI and ODI did not vary between age categories.</div></div><div><h3>Conclusions</h3><div>A weak correlation was observed between therapeutic CPAP pressure and MOAHI in our cohort of children, with no correlation with BMI, highlighting the potential role of other factors, such as anatomical features. Future studies should confirm these findings with PSG-titrated CPAP pressures, and determine predictive factors for therapeutic CPAP. Predicting the level of CPAP may be relevant in clinical practice, as PSG-titrated CPAP procedure becomes more challenging.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 89-93"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putamen dopaminergic dysfunction is associated with sleep disturbance in drug-naïve patients with Parkinson's disease","authors":"Masakazu Ozawa ,&nbsp;Hidetomo Murakami ,&nbsp;Yuichiro Muraoka ,&nbsp;Momoyo Ibukuro ,&nbsp;Tomotaka Shiraishi ,&nbsp;Asako Onda ,&nbsp;Hiromasa Matsuno ,&nbsp;Keiko Bono ,&nbsp;Tadashi Umehara ,&nbsp;Shusaku Omoto ,&nbsp;Hirotaka James Okano ,&nbsp;Yasuyuki Iguchi","doi":"10.1016/j.sleep.2025.02.031","DOIUrl":"10.1016/j.sleep.2025.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbance (SD) is common in Parkinson's disease (PD) and adversely affect the quality of life (QOL). Although dopamine dysfunction has been implicated, the specific role of dopaminergic activity in SD among patients with PD remains unclear. Given that dopamine-related medications can affect sleep, it is essential to assess SD in drug-naïve patients. This study investigated the association between SD and uptake of striatal dopamine transporters using Dopamine Transporter Single-Photon Emission Computed Tomography with ¹²³I-Ioflupane (DAT-SPECT).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 112 drug-naïve patients through the PD Sleep Scale-version-2 (PDSS-2) and DAT-SPECT. Patients were divided into SD and non-SD groups using a PDSS-2 cut-off score of 15. The Mann-Whitney <em>U</em> test and binomial regression were used to compare the groups.</div></div><div><h3>Results</h3><div>SD was identified in 47.3 % of participants, correlating significantly with increased age, more severe motor symptoms, cognitive decline, depressive symptoms, and reduced QOL scores. Binomial regression analyses—adjusted for sex, age, motor dysfunction, cognitive function, and nocturnal autonomic cardiovascular dysfunction—showed that reduced DAT-SPECT uptake in the left anterior and posterior putamen significantly contributed to higher PDSS-2 scores.</div></div><div><h3>Conclusion</h3><div>This study demonstrated a link between SD and putamen DAT-SPECT uptake in drug-naïve patients with PD, indicating the role of dopamine in sleep regulation. These findings underscore the importance of managing SD in patients with PD to improve QOL and suggest the need for further investigation of the impact of dopaminergic dysfunction on sleep.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 82-88"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and prognosis of acute ischemic stroke related restless legs syndrome","authors":"Xi-Xi Wang ,&nbsp;Ye Liu ,&nbsp;Jia-Min Song ,&nbsp;Yu-Lei Zhang ,&nbsp;Yu Wang ,&nbsp;Ondo G. William ,&nbsp;Ya Feng ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.sleep.2025.02.030","DOIUrl":"10.1016/j.sleep.2025.02.030","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies suggest that stroke may be associated with an increased prevalence of restless legs syndrome (RLS) as a comorbidity or a risk factor. We aimed to explore the association between acute ischemic stroke (AIS) and RLS, and the possible pathogenesis of acute ischemic stroke related restless legs syndrome (AIS-RLS), for guiding its diagnosis and treatment.</div></div><div><h3>Methods</h3><div>In this single-center, prospective study, we identified consecutive AIS patients and segregated into AIS-RLS group and non-AIS-RLS group based on the diagnostic criteria of RLS. The differences in baseline data, clinical features, examination results, stroke etiology, stroke location, and clinical prognosis (functional disability, cognitive and mood disorders) of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for RLS.</div></div><div><h3>Results</h3><div>A total of 201 AIS patients were included in our study, and 21 (10.45 %) demonstrated RLS. Compared with non-AIS-RLS group, AIS-RLS group patients had higher systolic blood pressure (SBP) at admission (<em>P</em> &lt; 0.05), higher mean 24-h SBP (<em>P</em> &lt; 0.01), higher mean 24-h diastolic blood pressure (DBP) (<em>P</em> &lt; 0.01), higher mean daytime SBP (<em>P</em> &lt; 0.01), higher mean daytime DBP (<em>P</em> &lt; 0.01), higher mean nocturnal SBP (<em>P</em> &lt; 0.01), higher mean nocturnal DBP (<em>P</em> &lt; 0.05), smaller variation coefficient of 24-h SBP (<em>P</em> &lt; 0.05). The distribution of AIS-RLS and non-AIS-RLS was not different for each subtype according to the cortical and subcortical classification of lesion sites. The NIHSS score, GAD-7 score and PHQ-9 score were higher at 7 days (<em>P</em> &lt; 0.05), and the modified Rankin scale (mRS) was higher at 3 months follow-up (<em>P</em> &lt; 0.05) in the AIS-RLS group. In the logistic regression, the higher SBP at admission had a statistically significant effect on AIS-RLS(OR = 1.030,<em>P</em> = 0.016)even after adjusting for age and gender(OR = 1.030,<em>P</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>Stroke anatomy did not differ between AIS-RLS and non-AIS-RLS groups. AIS-RLS group patients tend to experience higher blood pressure. Moreover, AIS-RLS patients had worse clinical prognosis (functional disability and mood disorders) compared with non-AIS-RLS patients.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 75-81"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic beds for the treatment of positional obstructive sleep apnea – A randomized cross-over pilot trial","authors":"Martina Meszaros ,&nbsp;Alexander Breuss ,&nbsp;Elisabeth Wilhelm ,&nbsp;Robert Riener ,&nbsp;Malcolm Kohler ,&nbsp;Esther I. Schwarz","doi":"10.1016/j.sleep.2025.02.025","DOIUrl":"10.1016/j.sleep.2025.02.025","url":null,"abstract":"<div><h3>Background</h3><div>Interventions leading to avoidance of supine position and thus reducing the likelihood of upper airway collapse during sleep are a treatment approach for positional obstructive sleep apnea (POSA). The aim of this randomized cross-over trial was to assess the effect of two actuated beds (trunk-elevation and sideward-tilting) on OSA severity and sleep fragmentation in POSA.</div></div><div><h3>Methods</h3><div>After baseline polysomnography, adult patients with POSA were randomly assigned to two nights of intervention in the intelligent sleep apnea bed ISABel1 and ISABel2. In the case of obstructive apnea or hypopnea, ISABel1 elevated the upper body by 50° and ISABel2 induced a unilateral bed tilt of 40°, with both interventions lasting 10 min. Sustained trunk elevations without sliding down (ISABel1) and position change from supine to non-supine (ISABel2) were defined as successful interventions.</div></div><div><h3>Results</h3><div>Six adult men (57 ± 11 years, BMI 28 ± 4 kg/m2, AHI 39 ± 15/h) with POSA were included. Neither trunk elevation (ISABel1) nor side tilt (ISABel2) – approximately 10 interventions per night – significantly reduced apnea-hypopnea index (AHI), whereas trunk elevation showed a tendency to reduce supine AHI. Actuated beds had no effect on sleep efficiency and arousals. Only 13 % of side tilts in ISABel2 resulted in a successful shift to a non-supine position. The time to the next respiratory event after bed movement was longer in the trunk elevating bed than in the side-tilting bed.</div></div><div><h3>Conclusion</h3><div>Trunk elevating beds decrease supine AHI and both side-tilting and trunk elevating beds increase the time to the next obstructive apnea or hypopnea.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 94-100"},"PeriodicalIF":3.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Web-based cognitive-behavioral therapy for insomnia in cancer survivors: The OncoSleep randomized trial","authors":"Maria I. Clara ,&nbsp;Annemieke van Straten ,&nbsp;Josée Savard ,&nbsp;Maria C. Canavarro ,&nbsp;Ana Allen Gomes","doi":"10.1016/j.sleep.2025.02.021","DOIUrl":"10.1016/j.sleep.2025.02.021","url":null,"abstract":"<div><h3>Purpose</h3><div>Insomnia is highly prevalent among cancer survivors and can have serious implications if inadequately treated. Cognitive-behavioral therapy for Insomnia (CBT-I) is recommended as the first-line treatment for insomnia but is rarely available to cancer survivors. We tested the effectiveness of a web-based CBT-I program, OncoSleep, in cancer survivors.</div></div><div><h3>Methods</h3><div>Cancer survivors with insomnia (n = 154) were randomly assigned (1:1) to digital CBT-I (6 weekly self-guided modules plus online clinician support) or a waitlist control group. Patient-reported outcome measures of insomnia severity (primary outcome), daytime functioning, and sleep diaries were administered online at baseline and post-treatment (8 weeks). Intention-to-treat analyses were performed using mixed-effects models. Statistical tests were two-sided.</div></div><div><h3>Results</h3><div>The treatment group reported an average 11.0-point reduction in the Insomnia Severity index (ISI), compared to a 1.4-point reduction in the control group (<em>p&lt;</em>.001). Statistically significant group-by-time interactions were observed: web-based CBT-I produced significant, large effects for improvements in insomnia severity (<em>d</em> = −2.56), cognitive functioning (<em>d</em> = 0.95), physical (<em>d</em> = 1.24) and psychological quality of life (<em>d</em> = 0.80), and fatigue (<em>d</em> = −1.35). Small-to-large effect sizes were found for reductions in anxiety (<em>d</em> = −0.77), depression (<em>d</em> = −0.71), and pain (<em>d</em> = −0.40). Change in insomnia severity mediated the effect of digital CBT-I on daytime outcomes.</div></div><div><h3>Conclusions</h3><div>Web-based CBT-I with clinician support appears to be an effective treatment for insomnia in cancer survivors, offering meaningful benefits for comorbid symptoms and quality of life. Further studies with active comparisons and longer follow-up periods are needed to confirm these findings. Digital CBT-I could be integrated into cancer rehabilitation programs to reduce the burden of insomnia. [ClinicalTrials.gov: <span><span>NCT04898855</span><svg><path></path></svg></span>].</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 67-74"},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep problems in youth with WAGR syndrome","authors":"Gavriela B. Kalish-Schur ,&nbsp;Mahalakshmi Somayaji ,&nbsp;Lisa J. Meltzer ,&nbsp;Christopher M. Cielo","doi":"10.1016/j.sleep.2025.02.018","DOIUrl":"10.1016/j.sleep.2025.02.018","url":null,"abstract":"<div><h3>Objectives</h3><div>Children with WAGR syndrome, an ultra-rare genetic condition associated with deletion of the brain-derived neurotrophic factor (BDNF), may be at increased risk for sleep problems, but there are limited data assessing sleep in this population. This study aimed to compare sleep disturbances and sleep-disordered breathing in youth with WAGR syndrome compared to healthy youth.</div></div><div><h3>Methods</h3><div>Parents of youth with WAGR syndrome and healthy controls completed an online survey including demographics, the PROMIS Pediatric Sleep Disturbance item bank, and the Pediatric Sleep Questionnaire Sleep-Related Breathing Disorders scale (PSQ-SRBD).</div></div><div><h3>Results</h3><div>Fifteen youth with WAGR syndrome, median (interquartile range) age 10 (7,11) years and 27 controls 9 (6, 10) years were included. PROMIS Sleep Disturbance T-scores were higher in youth with WAGR syndrome (58.1 [53.3, 66.1]) versus controls (52.5 [44.3, 58.3], p = 0.03) indicating more sleep disturbance. Melatonin was used for sleep in 7 (47 %) youth with WAGR syndrome versus 3 (11 %) controls (p = 0.009). PSQ-SRBD scores were greater in youth with WAGR syndrome (0.52 [0.45, 0.65]) compared to controls (0.09 [0.05, 0.18], p &lt; 0.001); 93 % of youth with WAGR syndrome had elevated PSQ-SRBD scores. One-third of youth with WAGR syndrome reported having a diagnosis of obstructive sleep apnea. No differences in sleep outcomes were identified based on BDNF deletion status in those with WAGR syndrome.</div></div><div><h3>Conclusions</h3><div>Sleep disturbances and sleep-disordered breathing are prevalent in youth with WAGR syndrome. Diverse cohorts with clinical data including polysomnography are needed to confirm these findings.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 101-104"},"PeriodicalIF":3.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter changes in patients with narcolepsy type 2: Peak width of skeletonized mean diffusivity study","authors":"Sujin Kang ,&nbsp;Dong Ah Lee ,&nbsp;Jun Won Lee ,&nbsp;Ho-Joon Lee ,&nbsp;Kang Min Park","doi":"10.1016/j.sleep.2025.02.020","DOIUrl":"10.1016/j.sleep.2025.02.020","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate white matter (WM) microstructural alterations in patients with narcolepsy type 2 (NT2) using Peak Width of Skeletonized Mean Diffusivity (PSMD), a novel imaging marker associated with small vessel disease (SVD). The study compared PSMD metrics between patients with NT2 and healthy controls to investigate structural disruptions and their implications for NT2 pathophysiology.</div></div><div><h3>Methods</h3><div>A total of 42 participants were enrolled, including 20 patients with newly diagnosed NT2 and 22 healthy controls. Diffusion tensor imaging (DTI) was performed using a 3 T MRI scanner. PSMD was calculated using a multi-step process involving preprocessing, skeletonization, application of a custom mask, and histogram analysis with the FSL program. PSMD values were compared between patients with NT2 and healthy controls, and correlation analyses were conducted to examine associations between PSMD and clinical variables.</div></div><div><h3>Results</h3><div>Patients with NT2 exhibited significantly higher PSMD compared to healthy controls (2.172 × 10⁻⁴ mm²/s vs. 2.031 × 10⁻⁴ mm²/s, <em>p</em> = 0.011). PSMD also positively correlated with age in both patients with NT2 (<em>r</em> = 0.608, <em>p</em> = 0.004) and healthy controls (<em>r</em> = 0.696, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Patients with NT2 demonstrate increased PSMD, indicating WM microstructural changes potentially linked to SVD. These findings highlight the utility of PSMD as a sensitive neuroimaging marker for detecting WM alterations in sleep disorders. Further studies are needed to validate these results and investigate the underlying mechanisms of WM changes in NT2.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 14-19"},"PeriodicalIF":3.8,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of GLP-1 receptor agonists in the management of obstructive sleep apnea in individuals without diabetes: A systematic review and meta-analysis of randomized, placebo-controlled trials","authors":"Chia Siang Kow ,&nbsp;Dinesh Sangarran Ramachandram ,&nbsp;Syed Shahzad Hasan ,&nbsp;Kaeshaelya Thiruchelvam","doi":"10.1016/j.sleep.2025.02.010","DOIUrl":"10.1016/j.sleep.2025.02.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Obstructive sleep apnea (OSA) is a common sleep disorder that disrupts breathing during sleep. While continuous positive airway pressure therapy is the standard treatment, poor adherence has led to exploration of alternative treatments. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to reduce body weight and may help manage OSA. This systematic review and meta-analysis evaluated the efficacy and safety of GLP-1 RAs in individuals with OSA and elevated body weight who are without diabetes.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in September 2024 across multiple databases. Randomized controlled trials (RCTs) evaluating GLP-1 RAs for OSA in adults with a body mass index (BMI) ≥30 kg/m² were included. The primary outcomes were changes in the apnea-hypopnea index (AHI) and overall adverse events. Meta-analyses were performed using a random-effects model.</div></div><div><h3>Results</h3><div>Three RCTs were included in the analysis. Pooled results showed that GLP-1 RA treatment significantly reduced AHI compared to placebo, with a weighted mean difference (WMD) of −16.6 events per hour (95 % confidence interval [CI]: −27.9 to −5.3). However, GLP-1 RAs were associated with a higher frequency of adverse events, with an odds ratio (OR) of 1.62 (95 % CI: 1.16 to 2.24) compared to placebo.</div></div><div><h3>Conclusion</h3><div>GLP-1 RAs effectively reduce OSA severity, offering a promising alternative for individuals with OSA and elevated body weight. However, the increased risk of side effects must be considered. Further long-term studies are needed to confirm the sustained benefits and safety of GLP-1 RAs in OSA management.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 40-44"},"PeriodicalIF":3.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to the editor regarding ‘Effect of lemborexant on sleep architecture in participants with insomnia disorder and mild obstructive sleep apnea’ by Kushida et al.”","authors":"Clete A. Kushida ,&nbsp;Gary K. Zammit ,&nbsp;Jocelyn Y. Cheng ,&nbsp;Dinesh Kumar ,&nbsp;Margaret Moline","doi":"10.1016/j.sleep.2025.02.014","DOIUrl":"10.1016/j.sleep.2025.02.014","url":null,"abstract":"","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"128 ","pages":"Page 195"},"PeriodicalIF":3.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aperiodic and periodic components of resting-state EEG in primary insomnia","authors":"Duo Bai ,&nbsp;Yatong Guo ,&nbsp;Simon Jülich ,&nbsp;Xu Lei","doi":"10.1016/j.sleep.2025.02.007","DOIUrl":"10.1016/j.sleep.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia is one of the most prevalent health concerns within the general population, with a multitude of existing electroencephalographic (EEG) spectral studies supporting heightened levels of high-frequency EEG activity as an index of cortical arousal. Nevertheless, traditional spectral analysis has been limited by its inability to distinguish between aperiodic and periodic elements. In contrast, a novel method, Spectral Parameterization (SpecParam), can separate these components and reveal the neural mechanisms of cortical arousal.</div></div><div><h3>Methods</h3><div>The aperiodic and periodic activities of 42 insomnia disorder (ID) patients and 45 age- and sex-matched healthy controls (HC) were evaluated during eyes-closed resting state. The associations between behavioral scales and aperiodic/periodic parameters were further examined to elucidate the underlying psychophysiological significance.</div></div><div><h3>Results</h3><div>We found that the aperiodic exponent was diminished in the ID group compared to the HC group. Additionally, the ID group exhibited an elevated central frequency and a more constrained bandwidth for periodic activity within the alpha band. Within-group correlation analyses revealed that a reduced exponent was associated with worse sleep quality and more frequent failures in inhibitory control within the ID group.</div></div><div><h3>Conclusions</h3><div>A smaller exponent within the ID group may reflect impaired inhibitory neuronal activity, potentially leading to cortical hyperarousal. The association of a smaller exponent with deteriorated sleep quality and impaired inhibitory control supports this hypothesis. Furthermore, the increased center frequency of the alpha band across extensive brain regions, along with a narrower alpha bandwidth in the left frontal and right parieto-occipital regions, may represent abnormal manifestations associated with excessive arousal. In summary, these results support the role of aperiodic activity as an index of impaired excitation/inhibition balance in neural activity within in ID group.</div></div>","PeriodicalId":21874,"journal":{"name":"Sleep medicine","volume":"129 ","pages":"Pages 45-54"},"PeriodicalIF":3.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}