Exploring the disintegration mechanism of dissolved natural plant products tablets based on pore structure control

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL Advanced Powder Technology Pub Date : 2024-08-23 DOI:10.1016/j.apt.2024.104586

Zhenda Liu , Xiao Lin , Yanlong Hong , Lijie Zhao , Lan Shen

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Abstract

Porosity variations have an impact on the disintegration behavior of tablets whereas the influence on the disintegration characteristics of natural plant product (NPP) tablets has not been extensively studied. Revealing the pore structure of NPP tablets provides a new and important clue to elucidate the phenomenal behavior and underlying mechanisms of tablet disintegration. In this study, the effect of porosity variation on disintegration of NPP tablets was evaluated for the first time. The disintegration performance of NPP tablets was evaluated using tablet attributes, disintegration kinetics, and the wicking process. Mercury intrusion porosimetry (MIP) and X-ray computed microtomography (XμCT) were used to characterize the microstructure of the tablets. Curcuma Longa Linn. extractions were compacted into tablets with different solid fractions. Tablet qualities changed significantly with increasing porosity. An increase in the wicking rate with porosity changed by visualizing the wicking process. The disintegration kinetics of tablets showed a sensitive variation after an increase in porosity. The pore structure of tablets including parameters such as pore size distribution, tortuosity, and connectivity were identified as direct drivers of wicking and disintegration. The current study provides new insights into the disintegration mechanism of dissolved NPP tablets by exploring the evolution of the pore microstructure.

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基于孔隙结构控制的天然植物溶解片剂崩解机理探索

孔隙率变化对片剂的崩解行为有影响，但对天然植物产品（NPP）片剂崩解特性的影响还没有广泛的研究。揭示 NPP 片剂的孔隙结构为阐明片剂崩解的现象行为和内在机制提供了新的重要线索。本研究首次评估了孔隙率变化对 NPP 片剂崩解的影响。通过片剂属性、崩解动力学和吸水过程对 NPP 片剂的崩解性能进行了评估。汞侵入孔测定法（MIP）和 X 射线计算机显微层析技术（XμCT）用于表征片剂的微观结构。将莪术提取物压制成不同固体组分的片剂。随着孔隙率的增加，片剂的质量发生了明显变化。通过目测吸水过程，吸水率随孔隙率的增加而变化。片剂的崩解动力学在孔隙率增加后出现了敏感变化。片剂的孔隙结构（包括孔径分布、迂回度和连通性等参数）被确定为舔噬和崩解的直接驱动因素。本研究通过探索孔隙微观结构的演变，对溶解的 NPP 片剂的崩解机制提供了新的见解。

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来源期刊

Advanced Powder Technology 工程技术-工程：化工

CiteScore

9.50

自引率

7.70%

发文量

424

审稿时长

55 days

期刊介绍： The aim of Advanced Powder Technology is to meet the demand for an international journal that integrates all aspects of science and technology research on powder and particulate materials. The journal fulfills this purpose by publishing original research papers, rapid communications, reviews, and translated articles by prominent researchers worldwide. The editorial work of Advanced Powder Technology, which was founded as the International Journal of the Society of Powder Technology, Japan, is now shared by distinguished board members, who operate in a unique framework designed to respond to the increasing global demand for articles on not only powder and particles, but also on various materials produced from them. Advanced Powder Technology covers various areas, but a discussion of powder and particles is required in articles. Topics include: Production of powder and particulate materials in gases and liquids(nanoparticles, fine ceramics, pharmaceuticals, novel functional materials, etc.); Aerosol and colloidal processing; Powder and particle characterization; Dynamics and phenomena; Calculation and simulation (CFD, DEM, Monte Carlo method, population balance, etc.); Measurement and control of powder processes; Particle modification; Comminution; Powder handling and operations (storage, transport, granulation, separation, fluidization, etc.)