Advanced Powder Technology最新文献

英文中文

Impact of acid surface pretreatment on the aggregation and flotation behavior of micro-fine ilmenite and its functional mechanism

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-03-04 DOI: 10.1016/j.apt.2025.104836

Yusheng Du , Qingyou Meng , Chong Han , Zhitao Yuan , Pengyu Zhang

Acid surface pretreatment was demonstrated as an effective method to enhance the floatability of ilmenite and promote selective collector adsorption on ilmenite versus gangue mineral surfaces. This study systematically investigated its role in improving the in-phase aggregation of micro-fine ilmenite particles. Microflotation experiment showed that the acid surface pretreatment enhanced the flotation recovery of micro-fine ilmenite and its combination with −45 +19 μm particle sizes from below 50 % to over 80 %. Turbidity, optical microscope, and laser particle size analyses confirmed that the acid surface pretreatment strengthened the original aggregation of micro-fine ilmenite within a pH range of 5.0 to 8.0. Atomic Force Microscope and E-DLVO theory analyses proved that the acid surface pretreatment primarily focused on reducing the surface hydrophilicity of micro-fine ilmenite. This reduction weakened the hydration interaction repulsion force between particles, leading to an increase in the total interaction attractive force, reinforcing the aggregation of micro-fine ilmenite. Micro-fine ilmenite treated with acid surface pretreatment easily absorbed on the in-phase ilmenite surfaces, facilitating the collection of micro-fine ilmenite with collectors. Taken together, the acid surface pretreatment is a potential method to strengthen the flotation recycling of micro-fine ilmenite.

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引用次数: 0

Comparative study of powder characteristics and mechanical properties of Al2024 nanocomposites reinforced with carbon-based additives

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-03-03 DOI: 10.1016/j.apt.2025.104835

Müslim Çelebi, Aykut Çanakçı, Serdar Özkaya

This study investigates the effects of nano-graphite (n-Gr), graphene nanoplatelets (GNPs), and carbon nanotubes (CNTs) as reinforcements on the powder characteristics, and physical and mechanical properties of Al2024-based nanocomposites fabricated via mechanical milling. Reinforcement content was varied from 0.5 wt% to 2 wt%, and the impact of the reinforcement type on particle size, morphology, hardness, and tensile strength was systematically evaluated. Results reveal that n-Gr reinforced composites exhibited flaky morphologies, higher particle sizes, and reduced hardness and tensile strength, attributed to limited embedding and agglomeration effects. In contrast, GNPs and CNTs demonstrated superior reinforcement capabilities, leading to finer powder sizes, enhanced hardness, and improved tensile strength. The largest powder size and the lowest particle hardness were obtained in the K₂ sample, measuring 52 µm and 130 HV, respectively, while the smallest powder size and the highest particle hardness were observed in the G₂ sample, measuring 29.4 µm and 179 HV, respectively. Among the reinforcements, GNPs showed the highest embedding efficiency and mechanical performance, achieving peak hardness and tensile strength at 1.5 wt% reinforcement. The hardness and tensile strength values of Al sample were 105 HB and 220 MPa, respectively, while the G_1.5 sample achieved values of 151 HB and 284 MPa, corresponding to approximately 50 % and 29 % increases. For CNTs reinforcement, the C₁ sample exhibited 16 % and 20 % increases, whereas n-Gr reinforcements consistently resulted in reductions.

{"title":"Comparative study of powder characteristics and mechanical properties of Al2024 nanocomposites reinforced with carbon-based additives","authors":"Müslim Çelebi, Aykut Çanakçı, Serdar Özkaya","doi":"10.1016/j.apt.2025.104835","DOIUrl":"10.1016/j.apt.2025.104835","url":null,"abstract":"<div><div>This study investigates the effects of nano-graphite (n-Gr), graphene nanoplatelets (GNPs), and carbon nanotubes (CNTs) as reinforcements on the powder characteristics, and physical and mechanical properties of Al2024-based nanocomposites fabricated via mechanical milling. Reinforcement content was varied from 0.5 wt% to 2 wt%, and the impact of the reinforcement type on particle size, morphology, hardness, and tensile strength was systematically evaluated. Results reveal that n-Gr reinforced composites exhibited flaky morphologies, higher particle sizes, and reduced hardness and tensile strength, attributed to limited embedding and agglomeration effects. In contrast, GNPs and CNTs demonstrated superior reinforcement capabilities, leading to finer powder sizes, enhanced hardness, and improved tensile strength. The largest powder size and the lowest particle hardness were obtained in the K<sub>2</sub> sample, measuring 52 µm and 130 HV, respectively, while the smallest powder size and the highest particle hardness were observed in the G<sub>2</sub> sample, measuring 29.4 µm and 179 HV, respectively. Among the reinforcements, GNPs showed the highest embedding efficiency and mechanical performance, achieving peak hardness and tensile strength at 1.5 wt% reinforcement. The hardness and tensile strength values of Al sample were 105 HB and 220 MPa, respectively, while the G<sub>1.5</sub> sample achieved values of 151 HB and 284 MPa, corresponding to approximately 50 % and 29 % increases. For CNTs reinforcement, the C<sub>1</sub> sample exhibited 16 % and 20 % increases, whereas n-Gr reinforcements consistently resulted in reductions.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104835"},"PeriodicalIF":4.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the hybrid explosion mechanism of multicomponent combustible gas-coal dust in a coal spontaneous combustion environment

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-03-01 DOI: 10.1016/j.apt.2025.104834

Shulin Zhang , Zhuo Wen , Xiang Yan , Lanning Wang , Yi Lu , Shiliang Shi

As coal mining depths increase, gas and coal dust explosions triggered by spontaneous coal combustion have become more severe, particularly with multiple combustible gases involved. This study investigated the kinetic mechanism of hybrid explosions combining multiple combustible gases and coal dust through experiments and theoretical analysis. Using a custom experimental setup, we examined three key factors: coal types, dust concentration, and gas components, measuring explosion temperature, pressure, and flame propagation velocity. Results showed that coal dust volatile content significantly influenced explosion characteristics, with higher content increasing temperature, pressure, and flame velocity. An optimal coal dust concentration for maximum explosion intensity was identified, showing an inverse relationship with gas concentration. Carbon monoxide’s impact was primarily determined by the ratio between methane concentration and its chemical equivalence value. FTIR analysis of explosion products revealed that gas-phase component changes significantly affected reaction processes, including pyrolysis and non-homogeneous combustion. Through thermodynamic dimensionless parameters Bi and Da, we quantified heat transfer dynamics and reaction kinetics, providing insights into energy dissipation patterns and supporting the development of environmentally sustainable safety protocols for coal extraction operations.

{"title":"Study on the hybrid explosion mechanism of multicomponent combustible gas-coal dust in a coal spontaneous combustion environment","authors":"Shulin Zhang , Zhuo Wen , Xiang Yan , Lanning Wang , Yi Lu , Shiliang Shi","doi":"10.1016/j.apt.2025.104834","DOIUrl":"10.1016/j.apt.2025.104834","url":null,"abstract":"<div><div>As coal mining depths increase, gas and coal dust explosions triggered by spontaneous coal combustion have become more severe, particularly with multiple combustible gases involved. This study investigated the kinetic mechanism of hybrid explosions combining multiple combustible gases and coal dust through experiments and theoretical analysis. Using a custom experimental setup, we examined three key factors: coal types, dust concentration, and gas components, measuring explosion temperature, pressure, and flame propagation velocity. Results showed that coal dust volatile content significantly influenced explosion characteristics, with higher content increasing temperature, pressure, and flame velocity. An optimal coal dust concentration for maximum explosion intensity was identified, showing an inverse relationship with gas concentration. Carbon monoxide’s impact was primarily determined by the ratio between methane concentration and its chemical equivalence value. FTIR analysis of explosion products revealed that gas-phase component changes significantly affected reaction processes, including pyrolysis and non-homogeneous combustion. Through thermodynamic dimensionless parameters Bi and Da, we quantified heat transfer dynamics and reaction kinetics, providing insights into energy dissipation patterns and supporting the development of environmentally sustainable safety protocols for coal extraction operations.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104834"},"PeriodicalIF":4.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of impact and compression stress in single particle breakage phenomena of multi-component systems

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-28 DOI: 10.1016/j.apt.2025.104802

Ann-Christin Brandt, Simon Bahnmüller, Finn Reinkensmeyer, Arno Kwade, Carsten Schilde

In the last decade, modelling and simulation of grinding processes has received considerable attention due to its critical role in optimising mill operations and improving the understanding of the mechanisms. This study focuses on the comparative analysis of the breakage behaviour of slags, a by-product of metallurgical processes, under compressive and impact loading. Using two different breakage testers, the research investigates the influence of slag particle size and composition on grindability, examining the breakage function, energy consumption and probability of particle breakage. The knowledge gained from testing different slag materials highlights the material specific responses to different stress mechanisms and emphasises the importance of selecting the appropriate grinding technology. The study shows the advantages of compressive stressing of slags in achieving the desired grain size reduction and energy efficiency. The results also highlight the need to choose a valid breakage model based on the specific material characteristics and stress mechanism applied. By providing a fundamental comparison of these breakage mechanisms, the study provides valuable data to guide the selection of grinding equipment to optimise both product quality and process efficiency in industrial applications. This research not only advances our understanding of slag reactivity and mechanical stability, but also supports the development of more sustainable materials processing techniques.

{"title":"Comparison of impact and compression stress in single particle breakage phenomena of multi-component systems","authors":"Ann-Christin Brandt, Simon Bahnmüller, Finn Reinkensmeyer, Arno Kwade, Carsten Schilde","doi":"10.1016/j.apt.2025.104802","DOIUrl":"10.1016/j.apt.2025.104802","url":null,"abstract":"<div><div>In the last decade, modelling and simulation of grinding processes has received considerable attention due to its critical role in optimising mill operations and improving the understanding of the mechanisms. This study focuses on the comparative analysis of the breakage behaviour of slags, a by-product of metallurgical processes, under compressive and impact loading. Using two different breakage testers, the research investigates the influence of slag particle size and composition on grindability, examining the breakage function, energy consumption and probability of particle breakage. The knowledge gained from testing different slag materials highlights the material specific responses to different stress mechanisms and emphasises the importance of selecting the appropriate grinding technology. The study shows the advantages of compressive stressing of slags in achieving the desired grain size reduction and energy efficiency. The results also highlight the need to choose a valid breakage model based on the specific material characteristics and stress mechanism applied. By providing a fundamental comparison of these breakage mechanisms, the study provides valuable data to guide the selection of grinding equipment to optimise both product quality and process efficiency in industrial applications. This research not only advances our understanding of slag reactivity and mechanical stability, but also supports the development of more sustainable materials processing techniques.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104802"},"PeriodicalIF":4.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of mineral species transformation driven by surface dielectric barrier discharge plasma modification on the flotation performances: Perspective of critical oxidation degree

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-26 DOI: 10.1016/j.apt.2025.104832

Jincheng Ran , Mao Sun , Pingshang Ji , Dingkun Peng , Zhiguo Zhang , Baoxu Song

Surface dielectric barrier discharge (SDBD) plasma modification has been proven to be an effective pretreatment method for flotation separation pyrite from arsenopyrite. However, there is limited quantitative research on the relationship between the surface species transformation of different components to flotation performance, which hinders the understanding of the selective surface modification mechanism driven by low-temperature plasma. In this study, the concept of critical oxidation degree was introduced to establish a correlation between total and individual component oxidation degrees and flotation recovery for varying particle sizes of arsenopyrite and pyrite. The findings revealed that fine particles exhibited higher critical oxidation degrees and rates, rendering them more susceptible to being oxidized into a hydrophilic state. The highest critical oxidation degree on the arsenopyrite surface was observed at the Fe site, however, it was prone to easy oxidation to Fe(III)–O/OH. The deposition of iron hydroxyl compounds limited ion exchange and the stable adsorption of the collector, resulting in the formation of a high hydrophilicity “metal-deficient” surface. Due to the high reactivity of surface As and Fe sites, arsenopyrite showed greater susceptibility to plasma modification compared to pyrite, laying the foundation for SDBD plasma induced flotation separation of arsenopyrite and pyrite.

{"title":"Effects of mineral species transformation driven by surface dielectric barrier discharge plasma modification on the flotation performances: Perspective of critical oxidation degree","authors":"Jincheng Ran , Mao Sun , Pingshang Ji , Dingkun Peng , Zhiguo Zhang , Baoxu Song","doi":"10.1016/j.apt.2025.104832","DOIUrl":"10.1016/j.apt.2025.104832","url":null,"abstract":"<div><div>Surface dielectric barrier discharge (SDBD) plasma modification has been proven to be an effective pretreatment method for flotation separation pyrite from arsenopyrite. However, there is limited quantitative research on the relationship between the surface species transformation of different components to flotation performance, which hinders the understanding of the selective surface modification mechanism driven by low-temperature plasma. In this study, the concept of critical oxidation degree was introduced to establish a correlation between total and individual component oxidation degrees and flotation recovery for varying particle sizes of arsenopyrite and pyrite. The findings revealed that fine particles exhibited higher critical oxidation degrees and rates, rendering them more susceptible to being oxidized into a hydrophilic state. The highest critical oxidation degree on the arsenopyrite surface was observed at the Fe site, however, it was prone to easy oxidation to Fe(III)–O/OH. The deposition of iron hydroxyl compounds limited ion exchange and the stable adsorption of the collector, resulting in the formation of a high hydrophilicity “metal-deficient” surface. Due to the high reactivity of surface As and Fe sites, arsenopyrite showed greater susceptibility to plasma modification compared to pyrite, laying the foundation for SDBD plasma induced flotation separation of arsenopyrite and pyrite.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104832"},"PeriodicalIF":4.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on inhibition of titanium powder explosion by melamine polyphosphate/iron modified carbon nanotube composite powder

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-25 DOI: 10.1016/j.apt.2025.104833

Yujian Zhu , Xiangbao Meng , Xiaozhen Yu , Zhao Qin , Jihe Chen , Jianxu Ding

In order to effectively inhibit the explosion of titanium powder, MPP-Fe@CNT mesoporous composite powder was prepared using carbon nanotubes as the carrier. Dust explosion experiment system and Hartmann experiment system were used to test the inhibition effect of MPP-Fe@CNT powder on the explosion pressure and explosion flame of titanium powder, and the explosion products were analyzed by FTIR and XPS experimental methods. The results show that when the proportion of MPP-Fe@CNT reaches 50 %, the maximum explosion pressure of titanium powder decreases from 0.5476 MPa to 0.2421 MPa, and the flame propagation distance decreases to 227.39 mm, which indicates that MPP-Fe@CNT has obvious inhibition effect on the explosion of titanium powder. MPP-Fe@CNT powder absorbs a lot of heat in the thermal decomposition process, and the released gas dilutes the concentration of oxygen. Chemical reactions of phosphorus-containing compounds consume free radicals and inhibit the explosion of titanium powder. Under the catalysis of iron, the polymer generated by decomposition and phosphorus-containing substances quickly form a dense carbonized film on the surface of titanium powder, blocking heat and oxygen, further limiting the explosive reaction, and having a good physicochemical synergistic inhibition effect to achieve a good effect of inhibiting the explosion of titanium powder.

{"title":"Study on inhibition of titanium powder explosion by melamine polyphosphate/iron modified carbon nanotube composite powder","authors":"Yujian Zhu , Xiangbao Meng , Xiaozhen Yu , Zhao Qin , Jihe Chen , Jianxu Ding","doi":"10.1016/j.apt.2025.104833","DOIUrl":"10.1016/j.apt.2025.104833","url":null,"abstract":"<div><div>In order to effectively inhibit the explosion of titanium powder, MPP-Fe@CNT mesoporous composite powder was prepared using carbon nanotubes as the carrier. Dust explosion experiment system and Hartmann experiment system were used to test the inhibition effect of MPP-Fe@CNT powder on the explosion pressure and explosion flame of titanium powder, and the explosion products were analyzed by FTIR and XPS experimental methods. The results show that when the proportion of MPP-Fe@CNT reaches 50 %, the maximum explosion pressure of titanium powder decreases from 0.5476 MPa to 0.2421 MPa, and the flame propagation distance decreases to 227.39 mm, which indicates that MPP-Fe@CNT has obvious inhibition effect on the explosion of titanium powder. MPP-Fe@CNT powder absorbs a lot of heat in the thermal decomposition process, and the released gas dilutes the concentration of oxygen. Chemical reactions of phosphorus-containing compounds consume free radicals and inhibit the explosion of titanium powder. Under the catalysis of iron, the polymer generated by decomposition and phosphorus-containing substances quickly form a dense carbonized film on the surface of titanium powder, blocking heat and oxygen, further limiting the explosive reaction, and having a good physicochemical synergistic inhibition effect to achieve a good effect of inhibiting the explosion of titanium powder.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104833"},"PeriodicalIF":4.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Front Cover (Aims & Scope, Editors)

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-24 DOI: 10.1016/S0921-8831(25)00043-3

引用次数: 0

Full title (Editorial Board Members)

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-24 DOI: 10.1016/S0921-8831(25)00044-5

引用次数: 0

Solventless-mixing particle coating using a high shear mixer for preparing coated pellets using dry methyl methacrylate and diethylaminoethyl methacrylate copolymer latex

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-21 DOI: 10.1016/j.apt.2025.104829

Keita Kondo, Shoko Mata, Toshiyuki Niwa

The aim of this study was to investigate the feasibility of coated pellet formulation by high shear mixing of drug pellets and polymer particles without solvent or heat. First, drug-layered pellets were prepared by high shear mixing of drug crystals and sugar-cellulose pellets. Second, aqueous methyl methacrylate and diethylaminoethyl methacrylate copolymer latex was solidified by freeze drying to produce dry latex comprising colloidal polymer. Finally, the resulting pellets and latex were exposed to high shear mixing, and the obtained coated pellets were characterized. The freeze-dried latex exhibited high coating performance due to its fragile characteristics, which were due to the lack of close contacts between the colloids. This latex was easily pulverized by high shear mixing with the pellets, and the resulting fragments were then deposited on the surface of the pellets. We examined additional coatings: after high shear mixing of the drug-layered pellets and latex particles, fresh latex was added and mixed with the coated pellets. This process provided coated pellets with thick and dense polymer layers, which could suppress initial drug release after annealed at 80 °C for 6 h. The dissolution was dependent on the coating thickness, which was determined by controlling the amount of coated polymer.

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引用次数: 0

Modulating hygroscopicity and compression performance in chewable mannitol-xylitol tablets: Effects of relative humidity and magnesium stearate

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology

Pub Date : 2025-02-21 DOI: 10.1016/j.apt.2025.104816

Yu Zhang , Hongyue Liu , Ge Zhong , Junmeng Xu , Jia Zeng , Fan Zhao , Jinru Hu , Chun Qiao , Li Qin , Ruofei Du

This study aims to investigate the effects of the relative humidity and formulation ratio on the hygroscopicity, tableting performance, and physical stability of polyols (mannitol and xylitol) as fillers in chewable tablets. To address the issues of hygroscopicity and sticking during tableting of chewable tablets containing polyol fillers, a systematic analysis was conducted by adjusting the ratio of mannitol and xylitol, and adding magnesium stearate (Mgst) as lubricant. The study investigated changes in hygroscopicity of the powder blends, tablet compressive force (F), and increment in ejection force (ΔEF) under varying humidity and formulation conditions. The porosity, tensile strength, and disintegration time of the tablets were also measured and analyzed to investigate the effects of humidity and formulation factors on tablet quality. The results indicate that increasing the mannitol content significantly reduces the hygroscopicity and moisture content of the powder blends. Higher levels of Mgst and mannitol improve the sticking issues in compression. However, an increase in mannitol content may decrease tablet porosity, leading to a longer disintegration time. Under high humidity conditions, increasing the amounts of mannitol can reduce the polymorphic transformation tendency of xylitol and enhance the hardness stability of the chewable tablets. This study reveals the significant effects of relative humidity and the mannitol-xylitol ratio on powder hygroscopicity, compaction performance, and tablet quality, providing a theoretical basis for optimizing formulations containing polyol fillers under controlled humidity conditions. The findings offer important references for adjusting process parameters in actual production, with particular guidance on improving tablet physical stability, anti-sticking performance, and disintegration control.

{"title":"Modulating hygroscopicity and compression performance in chewable mannitol-xylitol tablets: Effects of relative humidity and magnesium stearate","authors":"Yu Zhang , Hongyue Liu , Ge Zhong , Junmeng Xu , Jia Zeng , Fan Zhao , Jinru Hu , Chun Qiao , Li Qin , Ruofei Du","doi":"10.1016/j.apt.2025.104816","DOIUrl":"10.1016/j.apt.2025.104816","url":null,"abstract":"<div><div>This study aims to investigate the effects of the relative humidity and formulation ratio on the hygroscopicity, tableting performance, and physical stability of polyols (mannitol and xylitol) as fillers in chewable tablets. To address the issues of hygroscopicity and sticking during tableting of chewable tablets containing polyol fillers, a systematic analysis was conducted by adjusting the ratio of mannitol and xylitol, and adding magnesium stearate (Mgst) as lubricant. The study investigated changes in hygroscopicity of the powder blends, tablet compressive force (F), and increment in ejection force (ΔEF) under varying humidity and formulation conditions. The porosity, tensile strength, and disintegration time of the tablets were also measured and analyzed to investigate the effects of humidity and formulation factors on tablet quality. The results indicate that increasing the mannitol content significantly reduces the hygroscopicity and moisture content of the powder blends. Higher levels of Mgst and mannitol improve the sticking issues in compression. However, an increase in mannitol content may decrease tablet porosity, leading to a longer disintegration time. Under high humidity conditions, increasing the amounts of mannitol can reduce the polymorphic transformation tendency of xylitol and enhance the hardness stability of the chewable tablets. This study reveals the significant effects of relative humidity and the mannitol-xylitol ratio on powder hygroscopicity, compaction performance, and tablet quality, providing a theoretical basis for optimizing formulations containing polyol fillers under controlled humidity conditions. The findings offer important references for adjusting process parameters in actual production, with particular guidance on improving tablet physical stability, anti-sticking performance, and disintegration control.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 4","pages":"Article 104816"},"PeriodicalIF":4.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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