The impact of cadaveric donor transplant on the development of chronic rhinosinusitis and recalcitrant disease.

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY International Forum of Allergy & Rhinology Pub Date : 2024-08-24 DOI:10.1002/alr.23429

Estephania Candelo, Anyull D Bohorquez-Caballero, Karol Avila-Castano, Hani Wadei, Angela M Donaldson

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Abstract

Key points: The study found a higher incidence of chronic rhinosinusitis (CRS) and recalcitrant CRS in cadaveric organ transplant recipients compared to those receiving living donor transplants. Recipients of cadaveric transplants were 1.32 times more likely to develop CRS and 1.68 times more likely to develop medically recalcitrant CRS. Living kidney transplants significantly reduced the risk of developing CRS (OR = 0.12) and recalcitrant CRS (OR = 0.11), highlighting a potentially protective effect against these conditions. In contrast, cadaveric liver transplants were associated with an increased risk of CRS and medically recalcitrant CRS. Kaplan-Meier survival analysis indicated a significant difference in time to CRS onset between cadaveric and living donor transplants. Median time to CRS onset was longer for living donor recipients (21.1 months) compared to cadaveric recipients (15.6 months). This study underscores the need for transplant teams and otolaryngologist to consider donor type during transplant follow-up due to differing risks of CRS development.

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尸体供体移植对慢性鼻炎和顽固性疾病发展的影响。

要点研究发现，与接受活体器官移植的受者相比，尸体器官移植受者的慢性鼻炎（CRS）和顽固性CRS发病率更高。尸体器官移植受者患 CRS 的几率是活体器官移植受者的 1.32 倍，患药物难治性 CRS 的几率是活体器官移植受者的 1.68 倍。活体肾移植大大降低了罹患CRS（OR = 0.12）和顽固性CRS（OR = 0.11）的风险，凸显了对这些疾病的潜在保护作用。相比之下，尸体肝移植与CRS和医学上顽固的CRS风险增加有关。Kaplan-Meier生存分析表明，尸体移植和活体移植的CRS发病时间存在显著差异。活体器官移植受者发生 CRS 的中位时间（21.1 个月）长于尸体器官移植受者（15.6 个月）。这项研究强调，由于 CRS 发生的风险不同，移植团队和耳鼻喉科医生在移植随访过程中需要考虑供体类型。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.